Search Results - "Morgunov, Alexey S"

Learning the molecular grammar of protein condensates from sequence determinants and embeddings by Saar, Kadi L., Morgunov, Alexey S., Qi, Runzhang, Arter, William E., Krainer, Georg, Lee, Alpha A., Knowles, Tuomas P. J.

“…Intracellular phase separation of proteins into biomolecular condensates is increasingly recognized as a process with a key role in cellular…”
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Ribozyme-catalysed RNA synthesis using triplet building blocks by Attwater, James, Raguram, Aditya, Morgunov, Alexey S, Gianni, Edoardo, Holliger, Philipp

“…RNA-catalyzed RNA replication is widely believed to have supported a primordial biology. However, RNA catalysis is dependent upon RNA folding, and this yields…”
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Protein Condensate Atlas from predictive models of heteromolecular condensate composition by Saar, Kadi L., Scrutton, Rob M., Bloznelyte, Kotryna, Morgunov, Alexey S., Good, Lydia L., Lee, Alpha A., Teichmann, Sarah A., Knowles, Tuomas P. J.

“…Biomolecular condensates help cells organise their content in space and time. Cells harbour a variety of condensate types with diverse composition and many are…”
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Serological fingerprints link antiviral activity of therapeutic antibodies to affinity and concentration by Fiedler, Sebastian, Devenish, Sean R. A., Morgunov, Alexey S., Ilsley, Alison, Ricci, Francesco, Emmenegger, Marc, Kosmoliaptsis, Vasilis, Theel, Elitza S., Mills, John R., Sholukh, Anton M., Aguzzi, Adriano, Iwasaki, Akiko, Lynn, Andrew K., Knowles, Tuomas P. J.

“…The effectiveness of therapeutic monoclonal antibodies (mAbs) against variants of the SARS-CoV-2 virus is highly variable. As target recognition of mAbs relies…”
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Towards a co‐crediting system for carbon and biodiversity by Tedersoo, Leho, Sepping, Jaan, Morgunov, Alexey S., Kiik, Martin, Esop, Kristiina, Rosenvald, Raul, Hardwick, Kate, Breman, Elinor, Purdon, Rachel, Groom, Ben, Venmans, Frank, Kiers, E. Toby, Antonelli, Alexandre

“…Societal Impact Statement Humankind is facing both climate and biodiversity crises. This article proposes the foundations of a scheme that offers tradable…”
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Both COVID-19 infection and vaccination induce high-affinity cross-clade responses to SARS-CoV-2 variants by Emmenegger, Marc, Fiedler, Sebastian, Brugger, Silvio D., Devenish, Sean R.A., Morgunov, Alexey S., Ilsley, Alison, Ricci, Francesco, Malik, Anisa Y., Scheier, Thomas, Batkitar, Leyla, Madrigal, Lidia, Rossi, Marco, Meisl, Georg, Lynn, Andrew K., Saleh, Lanja, von Eckardstein, Arnold, Knowles, Tuomas P.J., Aguzzi, Adriano

“…The B.1.1.529 (omicron) variant has rapidly supplanted most other SARS-CoV-2 variants. Using microfluidics-based antibody affinity profiling (MAAP), we have…”
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Catalysts from synthetic genetic polymers by Taylor, Alexander I., Pinheiro, Vitor B., Smola, Matthew J., Morgunov, Alexey S., Peak-Chew, Sew, Cozens, Christopher, Weeks, Kevin M., Herdewijn, Piet, Holliger, Philipp

“…Four different XNAs — polymers with backbone chemistries not found in nature, namely, arabino nucleic acids, 2′-fluoroarabino nucleic acids, hexitol nucleic…”
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Theoretical and Data-Driven Approaches for Biomolecular Condensates by Saar, Kadi L., Qian, Daoyuan, Good, Lydia L., Morgunov, Alexey S., Collepardo-Guevara, Rosana, Best, Robert B., Knowles, Tuomas P. J.

“…Biomolecular condensation processes are increasingly recognized as a fundamental mechanism that living cells use to organize biomolecules in time and space…”
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New Frontiers for Machine Learning in Protein Science by Morgunov, Alexey S., Saar, Kadi L., Vendruscolo, Michele, Knowles, Tuomas P.J.

“…[Display omitted] •Protein function is fundamentally reliant on inter-molecular interactions.•Protein interactions involve ensembles of conformational…”
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Machine learning-aided protein identification from multidimensional signatures by Zhang, Yuewen, Wright, Maya A, Saar, Kadi L, Challa, Pavankumar, Morgunov, Alexey S, Peter, Quentin A E, Devenish, Sean, Dobson, Christopher M, Knowles, Tuomas P J

“…The ability to determine the identity of specific proteins is a critical challenge in many areas of cellular and molecular biology, and in medical diagnostics…”
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Optimizing membrane-protein biogenesis through nonoptimal-codon usage by Morgunov, Alexey S, Babu, M Madan

“…Two studies provide insights into the distinct strategies used by prokaryotes and eukaryotes to pause translation in order to facilitate cotranslational…”
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Antibody Affinity Governs the Inhibition of SARS-CoV‑2 Spike/ACE2 Binding in Patient Serum by Fiedler, Sebastian, Piziorska, Monika A., Denninger, Viola, Morgunov, Alexey S., Ilsley, Alison, Malik, Anisa Y., Schneider, Matthias M., Devenish, Sean R. A., Meisl, Georg, Kosmoliaptsis, Vasilis, Aguzzi, Adriano, Fiegler, Heike, Knowles, Tuomas P. J.

“…The humoral immune response plays a key role in suppressing the pathogenesis of SARS-CoV-2. The molecular determinants underlying the neutralization of the…”
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Microfluidic Antibody Affinity Profiling Reveals the Role of Memory Reactivation and Cross-Reactivity in the Defense Against SARS-CoV‑2 by Denninger, Viola, Xu, Catherine K, Meisl, Georg, Morgunov, Alexey S, Fiedler, Sebastian, Ilsley, Alison, Emmenegger, Marc, Malik, Anisa Y, Piziorska, Monika A, Schneider, Matthias M, Devenish, Sean R. A, Kosmoliaptsis, Vasilis, Aguzzi, Adriano, Fiegler, Heike, Knowles, Tuomas P. J

“…Recent efforts in understanding the course and severity of SARS-CoV-2 infections have highlighted both potentially beneficial and detrimental effects of…”
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Optimizing membrane-protein biogenesis through nonoptimal-codon usage: two studies provide insights into the distinct strategies used by prokaryotes and eukaryotes to pause translation in order to facilitate cotranslational targeting of membrane proteins to the translocon by Morgunov, Alexey S, Babu, M. Madan

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