Search Results - "Morgenweck, Jenny"

Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics by Schmid, Cullen L., Kennedy, Nicole M., Ross, Nicolette C., Lovell, Kimberly M., Yue, Zhizhou, Morgenweck, Jenny, Cameron, Michael D., Bannister, Thomas D., Bohn, Laura M.

“…Biased agonism has been proposed as a means to separate desirable and adverse drug responses downstream of G protein-coupled receptor (GPCR) targets. Herein,…”
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Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria by Brust, Tarsis F, Morgenweck, Jenny, Kim, Susy A, Rose, Jamie H, Locke, Jason L, Schmid, Cullen L, Zhou, Lei, Stahl, Edward L, Cameron, Michael D, Scarry, Sarah M, Aubé, Jeffrey, Jones, Sara R, Martin, Thomas J, Bohn, Laura M

“…Agonists targeting the kappa opioid receptor (KOR) have been promising therapeutic candidates because of their efficacy for treating intractable itch and…”
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Novel Endomorphin Analogs Are More Potent and Longer-Lasting Analgesics in Neuropathic, Inflammatory, Postoperative, and Visceral Pain Relative to Morphine by Feehan, Amy K, Morgenweck, Jenny, Zhang, Xing, Amgott-Kwan, Ariel T, Zadina, James E

“…Activation of the mu-opioid receptor provides the gold standard for pain relief, but most opioids used clinically have adverse effects that have contributed to…”
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Anti‐Inflammatory Mesenchymal Stem Cells (MSC2) Attenuate Symptoms of Painful Diabetic Peripheral Neuropathy by Waterman, Ruth S., Morgenweck, Jenny, Nossaman, Bobby D., Scandurro, Anna E., Scandurro, Sophia A., Betancourt, Aline M.

“…Mesenchymal stem cells (MSCs) are very attractive candidates in cell‐based strategies that target inflammatory diseases. Preclinical animal studies and many…”
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Endomorphin analog analgesics with reduced abuse liability, respiratory depression, motor impairment, tolerance, and glial activation relative to morphine by Zadina, James E., Nilges, Mark R., Morgenweck, Jenny, Zhang, Xing, Hackler, Laszlo, Fasold, Melita B.

“…Opioids acting at the mu opioid receptor (MOR) are the most effective analgesics, however adverse side effects severely limit their use. Of particular…”
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Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPARγ mechanisms by Griggs, Ryan B., Donahue, Renee R., Morgenweck, Jenny, Grace, Peter M., Sutton, Amanda, Watkins, Linda R., Taylor, Bradley K.

“…Repeated administration of peroxisome proliferator-activated receptor gamma (PPARγ) agonists reduces neuropathic pain-like behavior and associated changes in…”
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Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus by Morgenweck, Jenny, Frankowski, Kevin J., Prisinzano, Thomas E., Aubé, Jeffrey, Bohn, Laura M.

“…The kappa opioid receptor (KOR) is involved in mediating pruritus; agonists targeting this receptor have been used to treat chronic intractable itch…”
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RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum by Shahani, Neelam, Swarnkar, Supriya, Giovinazzo, Vincenzo, Morgenweck, Jenny, Bohn, Laura M, Scharager-Tapia, Catherina, Pascal, Bruce, Martinez-Acedo, Pablo, Khare, Kshitij, Subramaniam, Srinivasa

“…The striatum of the brain coordinates motor function. Dopamine-related drugs may be therapeutic to patients with striatal neurodegeneration, such as…”
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Pioglitazone rapidly reduces neuropathic pain through astrocyte and non-genomic PPARγ mechanisms by Griggs, Ryan B., Donahue, Renee R., Morgenweck, Jenny, Grace, Peter M., Sutton, Amanda, Watkins, Linda R., Taylor, Bradley K.

“…Repeated administration of peroxisome proliferator-activated receptor gamma (PPARγ) agonists reduces neuropathic pain-like behavior and associated changes in…”
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A G Protein‐Biased Ligand of the Kappa Opioid Receptor is Antinociceptive and Antipruritic But Does Not Cause Sedation or Dysphoria by Brust, Tarsis F, Morgenweck, Jenny, Kim, Susy A, Rose, Jamie H, Locke, Jason L, Schmid, Cullen L, Zhou, Lei, Stahl, Edward L, Cameron, Michael D, Scarry, Sarah M, Aubé, Jeffrey, Jones, Sara R, Martin, Thomas J, Bohn, Laura M

“…Abstract only The kappa opioid receptor (KOR) has been pursued as a target to treat pain and pruritis (itch). In contrast to opioid narcotics that target…”
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Pioglitazone acts at spinal PPARγ To inhibit the development and maintenance of neuropathic pain by Morgenweck, Jenny

“…Recent studies show synthetic PPARγ thiazolidinediones (TZDs) rosiglitazone and pioglitazone, most notably implicated in treatment for type-2 diabetes, are…”
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Pioglitazone acts at spinal PPARgamma To inhibit the development and maintenance of neuropathic pain by Morgenweck, Jenny

“…Recent studies show synthetic PPARgamma thiazolidinediones (TZDs) rosiglitazone and pioglitazone, most notably implicated in treatment for type-2 diabetes, are…”
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