Hepatitis B vaccine in infants: a randomized controlled trial comparing gluteal versus anterolateral thigh muscle administration

Hepatitis B vaccine in infants: a randomized controlled trial comparing gluteal versus anterolateral thigh muscle administration

A significantly diminished antibody response to hepatitis B vaccine has been demonstrated in adults when the buttock is used as the injection site. However, in Brazil, the buttock continues to be recommended as site of injection for intramuscular administration of vaccines in infants. In this age gr...

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Bibliographic Details
Published in:Revista do Instituto de Medicina Tropical de São Paulo Vol. 43; no. 3; pp. 139 - 143
Main Authors: Alves, A S, Nascimento, C M, Granato, C H, Sato, H K, Morgato, M F, Pannuti, C S
Format: Journal Article
Language:English
Published: Brazil Instituto de Medicina Tropical de Sao Paulo 01-06-2001
Instituto de Medicina Tropical
Universidade de São Paulo (USP)
Subjects:
Buttocks
Gluteal injection
Hepatitis B
Hepatitis B Vaccines - administration & dosage
Humans
Immunization Schedule
Infant
Injection
Injections, Intramuscular - methods
Intramuscular
Thigh
TROPICAL MEDICINE
Vaccine efficacy
Gluteal injection
Infant
Injection
Intramuscular
Vaccine efficacy
Hepatitis B
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Summary:A significantly diminished antibody response to hepatitis B vaccine has been demonstrated in adults when the buttock is used as the injection site. However, in Brazil, the buttock continues to be recommended as site of injection for intramuscular administration of vaccines in infants. In this age group, there are no controlled studies evaluating the immunogenicity of the hepatitis B vaccine when administered at this site. In the present study, 258 infants were randomized to receive the hepatitis B vaccine either in the buttock (n = 123) or in the anterolateral thigh muscle (n = 135). The immunization schedule consisted of three doses of hepatitis B vaccine (Engerix Bregister mark or target, 10 microg) at 2, 4 and 9 months of age. There were no significant differences in the proportion of seroconversion (99.3% x 99.2%), or in the geometric mean titer of ELISA anti-HBs (1,862.1 x 1,229.0 mIU/mL) between the two groups. This study demonstrates that a satisfactory serological response can be obtained when the hepatitis B vaccine is administered intramuscularly into the buttock.
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ISSN:0036-4665
1678-9946
0036-4665
1678-9946
DOI:10.1590/S0036-46652001000300004