Search Results - "Morganti, C M"

Characterising effects of impact velocity on brain and behaviour in a model of diffuse traumatic axonal injury by Yan, E.B, Johnstone, V.P.A, Alwis, D.S, Morganti-Kossmann, M.-C, Rajan, R

“…Highlights • Impact velocity is a critical factor that determines brain injury outcomes. • WDIA model of brain injury can be altered to deliver different…”
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Animal models of traumatic brain injury: Is there an optimal model to reproduce human brain injury in the laboratory? by Morganti-Kossmann, M.C, Yan, E, Bye, N

“…Abstract Compared to other neurological diseases, the research surrounding traumatic brain injury (TBI) has a more recent history. The establishment and use of…”
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The duality of the inflammatory response to traumatic brain injury by Lenzlinger, P M, Morganti-Kossmann, M C, Laurer, H L, McIntosh, T K

“…One and a half to two million people sustain a traumatic brain injury (TBI) in the US each year, of which approx 70,000-90,000 will suffer from long-term…”
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Neurotransmitters in cerebrospinal fluid reflect pathological activity by STOVER, J. F., PLEINES, U. E., MORGANTI-KOSSMANN, M. C., KOSSMANN, T., LOWITZSCH, K., KEMPSKI, O. S.

“…The excitatory transmitters glutamate and aspartate become toxic whenever their extracellular levels are increased because of neuronal, glial and endothelial…”
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Effects of High-Intensity Strength Training on Multiple Risk Factors for Osteoporotic Fractures: A Randomized Controlled Trial by Nelson, Miriam E, Fiatarone, Maria A, Morganti, Christina M, Trice, Isaiah, Greenberg, Robert A, Evans, William J

“…Objective.—To determine how multiple risk factors for osteoporotic fractures could be modified by high-intensity strength training exercises in postmenopausal…”
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Dose related association of impact activity and bone mineral density in pre-pubertal girls by Scerpella, T A, Davenport, M, Morganti, C M, Kanaley, J A, Johnson, L M

“…Impact activity is an important contributor to bone accrual. Children engaging in such activity have been shown to have greater bone mineral density (BMD) than…”
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Production of cytokines following brain injury: beneficial and deleterious for the damaged tissue by Morganti-Kossman, M C, Lenzlinger, P M, Hans, V, Stahel, P, Csuka, E, Ammann, E, Stocker, R, Trentz, O, Kossmann, T

“…A profound inflammatory response is initiated immediately following traumatic brain injury (TBI) and is characterized by the release of several cytokines with…”
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Experimental Closed Head Injury: Analysis of Neurological Outcome, Blood-Brain Barrier Dysfunction, Intracranial Neutrophil Infiltration, and Neuronal Cell Death in Mice Deficient in Genes for Pro-Inflammatory Cytokines by Stahel, Philip F., Shohami, Esther, Younis, Firas M., Kariya, Karin, Otto, Viviane I., Lenzlinger, Philipp M., Grosjean, Maurice B., Eugster, Hans-Pietro, Trentz, Otmar, Kossmann, Thomas, Morganti-Kossmann, Maria C.

“…Cytokines are important mediators of intracranial inflammation following traumatic brain injury (TBI). In the present study, the neurological impairment and…”
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Strength improvements with 1 yr of progressive resistance training in older women by Morganti, C M, Nelson, M E, Fiatarone, M A, Dallal, G E, Economos, C D, Crawford, B M, Evans, W J

“…Thirty-nine healthy women (59.5 +/- 0.9 yr) were randomized to either a control group (CON) or a progressive resistance training group (PRT) that trained twice…”
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Cell activation and inflammatory response following traumatic axonal injury in the rat by Csuka, Esther, Hans, Volkmar H. J, Ammann, Emerita, Trentz, Otmar, Kossmann, Thomas, Morganti-Kossmann, Maria C

“…In a rat model of traumatic brain injury cell activation was characterized immunohistochemically from 2 h up to 2 weeks. Reactive astrocytosis became apparent…”
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TGF-beta is elevated in the CSF of patients with severe traumatic brain injuries and parallels blood-brain barrier function by Morganti-Kossmann, M C, Hans, V H, Lenzlinger, P M, Dubs, R, Ludwig, E, Trentz, O, Kossmann, T

“…Traumatic brain injury (TBI) induces local and systemic immunologic changes, release of cytokines, and cell activation. Perpetuation of these cascades may…”
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Oligodendrocyte-derived J1-160/180 extracellular matrix glycoproteins are adhesive or repulsive depending on the partner cell type and time of interaction by Morganti, M C, Taylor, J, Pesheva, P, Schachner, M

“…We have studied the functional involvement of J1-160 and J1-180 in the interaction between oligodendrocytes and neurons, astrocytes, or L cells in short- and…”
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Experimental Axonal Injury Triggers Interleukin-6 mRNA, Protein Synthesis and Release Into Cerebrospinal Fluid by Hans, Volkmar H. J., Kossmann, Thomas, Lenzlinger, Philipp M., Probstmeier, Rainer, Imhof, Hans-Georg, Trentz, Otmar, Morganti-Kossmann, Maria C.

“…Diffuse axonal injury is a frequent pathologic sequel of head trauma, which, despite its devastating consequences for the patients, remains to be fully…”
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Macrophage- and astrocyte-derived transforming growth factor β as a mediator of central nervous system dysfunction in acquired immune deficiency syndrome by WAHL, S. M, ALLEN, J. B, MCCARTNEY-FRANCIS, N, MORGANTI-KOSSMANN, M. C, KOSSMANN, T, ELLINGSWORTH, L, MAI, U. E. H, MERGENHAGEN, S. E, ORENSTEIN, J. M

“…The multifunctional cytokine, transforming growth factor beta (TGF-beta), was identified by immunocytochemistry in the brain tissues of four patients with…”
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Cytokines and neuropathology by Morganti-Kossmann, M C, Kossmann, T, Wahl, S M

“…Inflammatory processes in the brain require the cooperation of immunocompetent cells and glial cells, which communicate by secreting bidirectional mediators…”
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Traumatic Brain Injury Increases β‐Amyloid Peptide 1‐42 in Cerebrospinal Fluid by Raby, Charlotte A., Morganti‐Kossmann, Maria C., Kossmann, Thomas, Stahel, Philip F., Watson, M. Desiree, Evans, Lori M., Mehta, Pankaj D., Spiegel, Katharyn, Kuo, Yu‐Min, Roher, Alex E., Emmerling, Mark R.

“…: The β‐amyloid peptides, Aβ1‐42 and Aβ1‐40, were quantified in ventricular CSF taken daily for up to 3 weeks from six individuals with severe traumatic brain…”
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Soluble ICAM-1 in CSF coincides with the extent of cerebral damage in patients with severe traumatic brain injury by Pleines, U E, Stover, J F, Kossmann, T, Trentz, O, Morganti-Kossmann, M C

“…The intercellular adhesion molecule-1 (ICAM-1) expressed by endothelial cells is crucial in promoting adhesion and transmigration of circulating leukocytes…”
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Interleukin-6 and its soluble receptor in serum and cerebrospinal fluid after cerebral trauma by J. Hans, Volkmar H, Kossmann, Thomas, Joller, Helene, Otto, Viviane, Morganti-Kossmann, Maria-Cristina

“…Interleukin-6 (IL-6) and its soluble receptor (sIL-6-R) were measured in cerebrospinal fluid (CSF) and serum of 11 severely head injured patients for up to 3…”
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The role of the complement system in traumatic brain injury by Stahel, Philip F, Morganti-Kossmann, Maria C, Kossmann, Thomas

“…A traumatic impact to the brain induces an intracranial inflammatory response, which consequently leads to the development of brain edema and delayed neuronal…”
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IL-10 levels in cerebrospinal fluid and serum of patients with severe traumatic brain injury: relationship to IL-6, TNF- alpha , TGF- beta 1 and blood-brain barrier function by Csuka, E, Morganti-Kossmann, M C, Lenzlinger, P M, Joller, H, Trentz, O, Kossmann, T

“…Controlling the extent of inflammatory responses following brain injury may be beneficial since posttraumatic intracranial inflammation has been associated…”
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