Search Results - "Morgan, Suzanne R"

Antithrombotic efficacy of a novel factor Xa inhibitor, FXV673, in a canine model of coronary artery thrombolysis by Rebello, Sam S, Bentley, Ross G, Morgan, Suzanne R, Kasiewski, Charles J, Chu, Valeria, Perrone, Mark H, Leadley, Robert J

“…We compared the antithrombotic efficacy of a potent factor Xa inhibitor, FXV673, to heparin and RPR109891, a GPIIb/IIIa antagonist, when used as adjunctive…”
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Optimization of the β-Aminoester class of factor Xa inhibitors. part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity by Guertin, Kevin R, Gardner, Charles J, Klein, Scott I, Zulli, Allison L, Czekaj, Mark, Gong, Yong, Spada, Alfred P, Cheney, Daniel L, Maignan, Sebastian, Guilloteau, Jean-Pierre, Brown, Karen D, Colussi, Dennis J, Chu, Valeria, Heran, Christopher L, Morgan, Suzanne R, Bentley, Ross G, Dunwiddie, Christopher T, Leadley, Robert J, Pauls, Henry W

“…Further optimization of the β-aminoester class of factor Xa (fXa) inhibitors is described culminating in the identification of 9c ( FXV673), a potent and…”
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Identification and Initial Structure−Activity Relationships of a Novel Class of Nonpeptide Inhibitors of Blood Coagulation Factor Xa by Klein, Scott I, Czekaj, Mark, Gardner, Charles J, Guertin, Kevin R, Cheney, Daniel L, Spada, Alfred P, Bolton, Scott A, Brown, Karen, Colussi, Dennis, Heran, Christopher L, Morgan, Suzanne R, Leadley, Robert J, Dunwiddie, Christopher T, Perrone, Mark H, Chu, Valeria

“…The discovery and some of the basic structure−activity relationships of a series of novel nonpeptide inhibitors of blood coagulation Factor Xa is described…”
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Role of Short-Term Inhibition of Factor Xa by FXV673 in Arterial Passivation: A Study in a Chronic Model of Thrombosis in Conscious Dogs by Rebello, Sam S, Kasiewski, Charles J, Wang, Wei, Bentley, Ross G, Morgan, Suzanne R, Chu, Valeria, Colussi, Dennis, Brown, Karen, Perrone, Mark H, Leadley, Robert J

“…Factor Xa (fXa) plays a pivotal role in the activation of the coagulation system during thrombosis, but, unlike GPIIb/IIIa receptor antagonists, the role of…”
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Superiority of Enoxaparin Over Heparin in Combination With a GPIIb/IIIa Receptor Antagonist During Coronary Thrombolysis in Dogs by Rebello, Sam S, Kasiewski, Charles J, Bentley, Ross G, Morgan, Suzanne R, Chu, Valeria, Bostwick, Jeffrey S, Klein, Scott I, Perrone, Mark H, Leadley, Robert J

“…It is known that a low-molecular-weight heparin (LMWH) is more effective than unfractionated heparin in unstable angina/non-Q-wave myocardial infarction…”
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Pharmacodynamic Activity and Antithrombotic Efficacy of RPR120844, a Novel Inhibitor of Coagulation Factor Xa by Leadley, Robert J, Morgan, Suzanne R, Bentley, Ross, Bostwick, Jeffrey S, Kasiewski, Charles J, Heran, Christopher, Chu, Valeria, Brown, Karen, Moxey, Phillip, Ewing, W Richard, Pauls, Henry, Spada, Alfred P, Perrone, Mark H, Dunwiddie, Christopher T

“…These studies were designed to examine the pharmacodynamic profile and antithrombotic efficacy of RPR120844, a competitive inhibitor of coagulation factor Xa,…”
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Sulfonamidopyrrolidinone Factor Xa Inhibitors:  Potency and Selectivity Enhancements via P-1 and P-4 Optimization by Choi-Sledeski, Yong Mi, McGarry, Daniel G, Green, Daniel M, Mason, Helen J, Becker, Michael R, Davis, Roderick S, Ewing, William R, Dankulich, William P, Manetta, Vincent E, Morris, Robert L, Spada, Alfred P, Cheney, Daniel L, Brown, Karen D, Colussi, Dennis J, Chu, Valeria, Heran, Christopher L, Morgan, Suzanne R, Bentley, Ross G, Leadley, Robert J, Maignan, Sebastien, Guilloteau, Jean-Pierre, Dunwiddie, Christopher T, Pauls, Henry W

“…Sulfonamidopyrrolidinones were previously disclosed as a selective class of factor Xa (fXa) inhibitors, culminating in the identification of RPR120844 as a…”
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Design and Structure−Activity Relationships of Potent and Selective Inhibitors of Blood Coagulation Factor Xa by Ewing, William R, Becker, Michael R, Manetta, Vincent E, Davis, Roderick S, Pauls, Henry W, Mason, Helen, Choi-Sledeski, Yong Mi, Green, Daniel, Cha, Don, Spada, Alfred P, Cheney, Daniel L, Mason, Jonathan S, Maignan, Sebastien, Guilloteau, Jean-Pierre, Brown, Karen, Colussi, Dennis, Bentley, Ross, Bostwick, Jeff, Kasiewski, Charles J, Morgan, Suzanne R, Leadley, Robert J, Dunwiddie, Christopher T, Perrone, Mark H, Chu, Valeria

“…The discovery of a series of non-peptide factor Xa (FXa) inhibitors incorporating 3-(S)-amino-2-pyrrolidinone as a central template is described. After…”
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