Search Results - "Morgan, Rhys G"

Targeting β-catenin in acute myeloid leukaemia: past, present, and future perspectives by Wagstaff, Megan, Coke, Brandon, Hodgkiss, Georgia R, Morgan, Rhys G

“…Acute myeloid leukaemia (AML) is an aggressive disease of the bone marrow with a poor prognosis. Evidence suggests long established chemotherapeutic regimens…”
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LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells by Morgan, Rhys G, Ridsdale, Jenna, Payne, Megan, Heesom, Kate J, Wilson, Marieangela C, Davidson, Andrew, Greenhough, Alexander, Davies, Sara, Williams, Ann C, Blair, Allison, Waterman, Marian L, Tonks, Alex, Darley, Richard L

“…Canonical Wnt/β-catenin signaling is frequently dysregulated in myeloid leukemias and is implicated in leukemogenesis. Nuclear-localized β-catenin is…”
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Crosstalk between β-catenin and WT1 signaling activity in acute myeloid leukemia by Wagstaff, Megan, Tsaponina, Olga, Caalim, Gilian, Greenfield, Hayley, Milton-Harris, Leanne, Mancini, Erika J, Blair, Allison, Heesom, Kate J, Tonks, Alex, Darley, Richard L, Roberts, Stefan G, Morgan, Rhys G

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BCL-3 loss sensitises colorectal cancer cells to DNA damage by targeting homologous recombination by Parker, Christopher, Chambers, Adam C., Flanagan, Dustin J., Ho, Jasmine Wing Yu, Collard, Tracey J., Ngo, Greg, Baird, Duncan M., Timms, Penny, Morgan, Rhys G., Sansom, Owen J., Williams, Ann C.

“…The proto-oncogene BCL-3 is upregulated in a subset of colorectal cancers (CRC), where it has been shown to enhance tumour cell survival. However, although…”
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The PDK1 master kinase is over-expressed in acute myeloid leukemia and promotes PKC-mediated survival of leukemic blasts by Zabkiewicz, Joanna, Pearn, Lorna, Hills, Robert K, Morgan, Rhys G, Tonks, Alex, Burnett, Alan K, Darley, Richard L

“…PDK1 is a master kinase that activates at least six protein kinase groups including AKT, PKC and S6K and is a potential target in the treatment of a range of…”
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Factors Affecting the Nuclear Localization of β-Catenin in Normal and Malignant Tissue by Morgan, Rhys G., Ridsdale, Jenna, Tonks, Alex, Darley, Richard L.

“…ABSTRACT The canonical Wnt signaling pathway has been the focus of intensive research because of its frequent dysregulation in human cancers. Much of this has…”
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Detecting intracellular thiol redox state in leukaemia and heterogeneous immune cell populations: An optimised protocol for digital flow cytometers by Wadley, Alex J., Morgan, Rhys G., Heesom, Kate J., Hole, Paul S., Coles, Steven J.

“…[Display omitted] Flow cytometric methods for detecting and quantifying reduced intracellular thiol content using fluorescein-5-maleimide (F5M) in viable…”
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Characteristics of horizontal liquid–liquid flows in a circular pipe using simultaneous high-speed laser-induced fluorescence and particle velocimetry by Morgan, Rhys G., Markides, Christos N., Zadrazil, Ivan, Hewitt, Geoffrey F.

“…► Initially-stratified co-current horizontal liquid–liquid pipe flows have been studied. ► High-speed PLIF and PIV/PTV have been used for characterisation of…”
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Epstein-Barr Virus Genome Deletions in Epstein-Barr Virus-Positive T/NK Cell Lymphoproliferative Diseases by Wongwiwat, Wiyada, Fournier, Benjamin, Bassano, Irene, Bayoumy, Amr, Elgueta Karstegl, Claudio, Styles, Christine, Bridges, Ray, Lenoir, Christelle, BoutBoul, David, Moshous, Despina, Neven, Bénédicte, Kanda, Teru, Morgan, Rhys G, White, Robert E, Latour, Sylvain, Farrell, Paul J

“…The main target cells for Epstein-Barr virus (EBV) infection and persistence are B lymphocytes, although T and NK cells can also become infected. In this…”
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Assessment of mononuclear cell populations derived from human umbilical cord blood by Olaitan, Samuel, Wagstaff, Megan, Sevim, Okan, Akieme, Raquel, Toska, Valentina, Humphreys, Caroline, Shah‐Goodwin, Lorraine, Bell, John, Chevassut, Timothy, Morgan, Rhys G.

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Inhibition of GATA2 restrains cell proliferation and enhances apoptosis and chemotherapy mediated apoptosis in human GATA2 overexpressing AML cells by Menendez-Gonzalez, Juan Bautista, Sinnadurai, Samantha, Gibbs, Alex, Thomas, Leigh-anne, Konstantinou, Maria, Garcia-Valverde, Alfonso, Boyer, Magali, Wang, Zhengke, Boyd, Ashleigh S., Blair, Allison, Morgan, Rhys G., Rodrigues, Neil P.

“…GATA2, a zinc finger transcription factor predominantly expressed in hematopoietic cells, acts as an essential regulator of hematopoietic stem cell generation,…”
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Horizontal liquid–liquid flow characteristics at low superficial velocities using laser-induced fluorescence by Morgan, Rhys G., Markides, Christos N., Hale, Colin P., Hewitt, Geoffrey F.

“…► Laser-induced fluorescence has been used to visualise liquid–liquid flows. ► Eight flow regimes were observed including the positive identification of…”
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Preliminary evidence of reductive stress in human cytotoxic T-cells following exercise by Wadley, Alex James, Holliday, Adrian, Morgan, Rhys G, Heesom, Kate J, Aldred, Sarah, Peters, Derek M, Bueno, Allain A, Coles, Steven J

“…This study investigated immunophenotypic differences in intracellular thiol redox state of peripheral blood mononuclear cells (PBMCs) isolated from trained…”
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Using Flow Cytometry to Detect and Measure Intracellular Thiol Redox Status in Viable T Cells from Heterogeneous Populations by Wadley, Alex J, Morgan, Rhys G, Darley, Richard L, Hole, Paul S, Coles, Steven J

“…Increased production of reactive oxygen species (ROS) and deficiencies in cellular antioxidant defenses are the principal causes of cellular oxidative stress…”
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On the role of buoyancy-driven instabilities in horizontal liquid–liquid flow by Morgan, Rhys G., Ibarra, Roberto, Zadrazil, Ivan, Matar, Omar K., Hewitt, Geoffrey F., Markides, Christos N.

“…Horizontal flows of two initially stratified immiscible liquids with matched refractive indices, namely an aliphatic hydrocarbon oil (Exxsol D80) and an…”
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Factors Affecting the Nuclear Localization of [beta]-Catenin in Normal and Malignant Tissue by Morgan, Rhys G, Ridsdale, Jenna, Tonks, Alex, Darley, Richard L

“…The canonical Wnt signaling pathway has been the focus of intensive research because of its frequent dysregulation in human cancers. Much of this has been…”
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