Search Results - "Morgan, R Marc"
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A DNA damage–induced phosphorylation circuit enhances Mec1ATR Ddc2ATRIP recruitment to Replication Protein A
Published in Proceedings of the National Academy of Sciences - PNAS (04-04-2023)“…The cell cycle checkpoint kinase Mec1ATR and its integral partner Ddc2ATRIP are vital for the DNA damage and replication stress response. Mec1–Ddc2 "senses"…”
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A new class of hybrid secretion system is employed in Pseudomonas amyloid biogenesis
Published in Nature communications (15-08-2017)“…Gram-negative bacteria possess specialised biogenesis machineries that facilitate the export of amyloid subunits for construction of a biofilm matrix. The…”
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Crystal Structure of Geranylgeranyl Pyrophosphate Synthase (CrtE) Involved in Cyanobacterial Terpenoid Biosynthesis
Published in Frontiers in plant science (25-05-2020)“…Cyanobacteria are photosynthetic prokaryotes that perform oxygenic photosynthesis. Due to their ability to use the photon energy of sunlight to fix carbon…”
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Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System
Published in Cell reports (Cambridge) (31-10-2017)“…Selective recruitment of protein kinases to the Hsp90 system is mediated by the adaptor co-chaperone Cdc37. We show that assembly of CDK4 and CDK6 into protein…”
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Recognition of BRAF by CDC37 and Re-Evaluation of the Activation Mechanism for the Class 2 BRAF-L597R Mutant
Published in Biomolecules (Basel, Switzerland) (28-06-2022)“…The kinome specific co-chaperone, CDC37 (cell division cycle 37), is responsible for delivering BRAF (B-Rapidly Accelerated Fibrosarcoma) to the Hsp90 (heat…”
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6
A DNA damage-induced phosphorylation circuit enhances Mec1 ATR Ddc2 ATRIP recruitment to Replication Protein A
Published in Proceedings of the National Academy of Sciences - PNAS (04-04-2023)“…The cell cycle checkpoint kinase Mec1 and its integral partner Ddc2 are vital for the DNA damage and replication stress response. Mec1-Ddc2…”
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7
Serial Femtosecond Crystallography Reveals that Photoactivation in a Fluorescent Protein Proceeds via the Hula Twist Mechanism
Published in Journal of the American Chemical Society (26-07-2023)“…Chromophore cis/trans photoisomerization is a fundamental process in chemistry and in the activation of many photosensitive proteins. A major task is…”
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Observation of Cation Chromophore Photoisomerization of a Fluorescent Protein Using Millisecond Synchrotron Serial Crystallography and Infrared Vibrational and Visible Spectroscopy
Published in The journal of physical chemistry. B (17-11-2022)“…The chromophores of reversibly switchable fluorescent proteins (rsFPs) undergo photoisomerization of both the trans and cis forms. Concurrent with cis/trans…”
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Power Density Titration of Reversible Photoisomerization of a Fluorescent Protein Chromophore in the Presence of Thermally Driven Barrier Crossing Shown by Quantitative Millisecond Serial Synchrotron X‑ray Crystallography
Published in Journal of the American Chemical Society (07-06-2024)“…We present millisecond quantitative serial X-ray crystallography at 1.7 Å resolution demonstrating precise optical control of reversible population transfer…”
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The FapF Amyloid Secretion Transporter Possesses an Atypical Asymmetric Coiled Coil
Published in Journal of molecular biology (12-10-2018)“…Gram-negative bacteria possess specialized biogenesis machineries that facilitate the export of amyloid subunits, the fibers of which are key components of…”
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