Search Results - "Morgan, Phil G"

Cell Biology of the Mitochondrion by van der Bliek, Alexander M, Sedensky, Margaret M, Morgan, Phil G

“…Mitochondria are best known for harboring pathways involved in ATP synthesis through the tricarboxylic acid cycle and oxidative phosphorylation. Major advances…”
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A Putative Cation Channel and Its Novel Regulator: Cross-Species Conservation of Effects on General Anesthesia by Humphrey, John A., Hamming, Kevin S., Thacker, Colin M., Scott, Robert L., Sedensky, Margaret M., Snutch, Terrance P., Morgan, Phil G., Nash, Howard A.

“…Volatile anesthetics like halothane and enflurane are of interest to clinicians and neuroscientists because of their ability to preferentially disrupt higher…”
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Complex I Function Is Defective in Complex IV-deficient Caenorhabditis elegans by Suthammarak, Wichit, Yang, Yu-Ying, Morgan, Phil G., Sedensky, Margaret M.

“…Cytochrome c oxidase (COX) is hypothesized to be an important regulator of oxidative phosphorylation. However, no animal phenotypes have been described due to…”
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Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron–sulfur protein by Jafari, Gholamali, Wasko, Brian M, Tonge, Ashley, Schurman, Nathan, Dong, Cindy, Li, Zhongyu, Peters, Rebecca, Kayser, Ernst-Bernhard, Pitt, Jason N, Morgan, Phil G, Sedensky, Margaret M, Crofts, Antony R, Kaeberlein, Matt

“…Mitochondria play an important role in numerous diseases as well as normative aging. Severe reduction in mitochondrial function contributes to childhood…”
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Anesthetic considerations in patients with mitochondrial defects by Niezgoda, Julie, Morgan, Phil G.

“…Summary Mitochondrial disease, once thought to be a rare clinical entity, is now recognized as an important cause of a wide range of neurologic, cardiac,…”
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Mitochondrial Oxidative Phosphorylation Is Defective in the Long-lived Mutant clk-1 by Kayser, Ernst-Bernhard, Sedensky, Margaret M., Morgan, Phil G., Hoppel, Charles L.

“…The long-lived mutant of Caenorhabditis elegans, clk-1, is unable to synthesize ubiquinone, CoQ9. Instead, the mutant accumulates demethoxyubiquinone9 and…”
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Mitochondrial defects and anesthetic sensitivity by MORGAN, Phil G, HOPPEL, Charles L, SEDENSKY, Margaret M

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The effects of complex I function and oxidative damage on lifespan and anesthetic sensitivity in Caenorhabditis elegans by Kayser, Ernst-Bernhard, Sedensky, Margaret M, Morgan, Phil G

“…A mutation in a subunit of complex I of the mitochondrial electron transport chain ( gas-1) causes Caenorhabditis elegans to be hypersensitive to volatile…”
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Sulfated Signal from ASJ Sensory Neurons Modulates Stomatin-dependent Coordination in Caenorhabditis elegans by Carroll, Bryan T., Dubyak, George R., Sedensky, Margaret M., Morgan, Phil G.

“…The neuronal stomatin-like proteins UNC-1 and UNC-24 play important roles in the nervous system of Caenorhabditis elegans. These neuronal stomatin-like…”
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Mitochondrial complex I function affects Halothane sensitivity in caenorhabditis elegans by KAYSER, Ernst-Bernhard, MORGAN, Phil G, SEDENSKY, Margaret M

“…: The gene gas-1 encodes a subunit of complex I of the mitochondrial electron transport chain in Caenorhabditis elegans. A mutation in gas-1 profoundly…”
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Mutations in Mitochondrial Complex III Uniquely Affect Complex I in Caenorhabditis elegans by Suthammarak, Wichit, Morgan, Phil G., Sedensky, Margaret M.

“…Mitochondrial supercomplexes containing complexes I, III, and IV of the electron transport chain are now regarded as an established entity. Supercomplex…”
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Tail clamp responses in stomatin knockout mice compared with mobility assays in caenorhabditis elegans during exposure to diethyl ether, halothane, and isoflurane by SEDENSKY, Margaret M, PUJAZON, Melissa A, MORGAN, Phil G

“…The gene unc-1 plays a central role in determining volatile anesthetic sensitivity in Caenorhabditis elegans. Because different unc-1 alleles cause strikingly…”
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Mitochondrial mutations differentially affect aging, mutability and anesthetic sensitivity in Caenorhabditis elegans by Hartman, Phil S., Ishii, Naoaki, Kayser, Ernst-Bernhard, Morgan, Phil G., Sedensky, Margaret M.

“…In the nematode Caenorhabditis elegans, mutations have been previously isolated that affect the activities of Complex I ( gas-1) and Complex II ( mev-1), two…”
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Important New Model for Studying Anesthetic Action by Morgan, Phil G.

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Isoflurane Selectively Inhibits Distal Mitochondrial Complex I in Caenorhabditis Elegans by Kayser, Ernst-Bernhard, Suthammarak, Wichit, Morgan, Phil G., Sedensky, Margaret M.

“…Complex I of the electron transport chain (ETC) is a possible target of volatile anesthetics (VAs). Complex I enzymatic activities are inhibited by VAs, and…”
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Propofol Compared with Isoflurane Inhibits Mitochondrial Metabolism in Immature Swine Cerebral Cortex by Kajimoto, Masaki, Atkinson, Douglas B, Ledee, Dolena R, Kayser, Ernst-Bernhard, Morgan, Phil G, Sedensky, Margaret M, Isern, Nancy G, Des Rosiers, Christine, Portman, Michael A

“…Anesthetics used in infants and children are implicated in the development of neurocognitive disorders. Although propofol induces neuroapoptosis in developing…”
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The power of unbiased genetic screens to discover novel anesthetic targets by Morgan, Phil G, Sedensky, Margaret M

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A new phase in anesthetic-induced neurotoxicity research by Morgan, Phil G, Sedensky, Margaret

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A glimpse into the many possibilities that lie ahead by Rajaram, Shanta, Morgan, Phil G

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The role of DMQ(9) in the long-lived mutant clk-1 by Yang, Yu-Ying, Vasta, Valeria, Hahn, Sihoun, Gangoiti, Jon A, Opheim, Elyce, Sedensky, Margaret M, Morgan, Phil G

“…Ubiquinone (UQ) is a redox active lipid that transfers electrons from complex I or II to complex III in the electron transport chain (ETC). The long-lived…”
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