Search Results - "Morgan, Marc A."

Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation by Morgan, Marc A. J., Shilatifard, Ali

“…Histone-modifying enzymes are implicated in the control of diverse DNA-templated processes including gene expression. Here, we outline historical and current…”
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Chromatin signatures of cancer by Morgan, Marc A, Shilatifard, Ali

“…Changes in the pattern of gene expression play an important role in allowing cancer cells to acquire their hallmark characteristics, while genomic instability…”
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The MLL3/MLL4 Branches of the COMPASS Family Function as Major Histone H3K4 Monomethylases at Enhancers by Hu, Deqing, Gao, Xin, Morgan, Marc A., Herz, Hans-Martin, Smith, Edwin R., Shilatifard, Ali

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Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas by Piunti, Andrea, Hashizume, Rintaro, Morgan, Marc A, Bartom, Elizabeth T, Horbinski, Craig M, Marshall, Stacy A, Rendleman, Emily J, Ma, Quanhong, Takahashi, Yoh-hei, Woodfin, Ashley R, Misharin, Alexander V, Abshiru, Nebiyu A, Lulla, Rishi R, Saratsis, Amanda M, Kelleher, Neil L, James, C David, Shilatifard, Ali

“…Nucleosomes containing mutant K27M histones in diffuse intrinsic pediatric gliomas (DIPG) exclude PRC2 binding and recruit BET bromodomain proteins; however,…”
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Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation by Douillet, Delphine, Sze, Christie C., Ryan, Caila, Piunti, Andrea, Shah, Avani P., Ugarenko, Michal, Marshall, Stacy A., Rendleman, Emily J., Zha, Didi, Helmin, Kathryn A., Zhao, Zibo, Cao, Kaixiang, Morgan, Marc A., Singer, Benjamin D., Bartom, Elizabeth T., Smith, Edwin R., Shilatifard, Ali

“…The COMPASS protein family catalyzes histone H3 Lys 4 (H3K4) methylation and its members are essential for regulating gene expression. MLL2/COMPASS methylates…”
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Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability by Rickels, Ryan, Herz, Hans-Martin, Sze, Christie C, Cao, Kaixiang, Morgan, Marc A, Collings, Clayton K, Gause, Maria, Takahashi, Yoh-hei, Wang, Lu, Rendleman, Emily J, Marshall, Stacy A, Krueger, Annika, Bartom, Elizabeth T, Piunti, Andrea, Smith, Edwin R, Abshiru, Nebiyu A, Kelleher, Neil L, Dorsett, Dale, Shilatifard, Ali

“…Ali Shilatifard and colleagues generate Drosophila lines expressing catalytically deficient Trr, which normally deposits H3K4me1 at enhancers. Trr mutants…”
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Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy by Wang, Lu, Zhao, Zibo, Ozark, Patrick A., Fantini, Damiano, Marshall, Stacy A., Rendleman, Emily J., Cozzolino, Kira A., Louis, Nundia, He, Xingyao, Morgan, Marc A., Takahashi, Yoh-hei, Collings, Clayton K., Smith, Edwin R., Ntziachristos, Panagiotis, Savas, Jeffrey N., Zou, Lihua, Hashizume, Rintaro, Meeks, Joshua J., Shilatifard, Ali

“…The lysine methyltransferase KMT2C (also known as MLL3), a subunit of the COMPASS complex, implements monomethylation of Lys4 on histone H3 (H3K4) at gene…”
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The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells by Hu, Deqing, Garruss, Alexander S, Gao, Xin, Morgan, Marc A, Cook, Malcolm, Smith, Edwin R, Shilatifard, Ali

“…Embryonic stem cells (ESCs) possess a unique chromatin landscape in which 'bivalent' domains of trimethylated histone H3 Lys4 (H3K4me3) and Lys27 (H3K27me3)…”
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Histone H3K4 methylation-dependent and -independent functions of Set1A/COMPASS in embryonic stem cell self-renewal and differentiation by Sze, Christie C, Cao, Kaixiang, Collings, Clayton K, Marshall, Stacy A, Rendleman, Emily J, Ozark, Patrick A, Chen, Fei Xavier, Morgan, Marc A, Wang, Lu, Shilatifard, Ali

“…Of the six members of the COMPASS (complex of proteins associated with Set1) family of histone H3 Lys4 (H3K4) methyltransferases identified in mammals, Set1A…”
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Epigenetic moonlighting: Catalytic-independent functions of histone modifiers in regulating transcription by Morgan, Marc A J, Shilatifard, Ali

“…The past three decades have yielded a wealth of information regarding the chromatin regulatory mechanisms that control transcription. The "histone code"…”
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Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life by Elias, Salah, Morgan, Marc A., Bikoff, Elizabeth K., Robertson, Elizabeth J.

“…The hierarchical relationships between various stem and progenitor cell subpopulations driving mammary gland morphogenesis and homoeostasis are poorly…”
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SET1A/COMPASS and shadow enhancers in the regulation of homeotic gene expression by Cao, Kaixiang, Collings, Clayton K, Marshall, Stacy A, Morgan, Marc A, Rendleman, Emily J, Wang, Lu, Sze, Christie C, Sun, Tianjiao, Bartom, Elizabeth T, Shilatifard, Ali

“…The homeotic (Hox) genes are highly conserved in metazoans, where they are required for various processes in development, and misregulation of their expression…”
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Lactate-dependent transcriptional regulation controls mammalian eye morphogenesis by Takata, Nozomu, Miska, Jason M., Morgan, Marc A., Patel, Priyam, Billingham, Leah K., Joshi, Neha, Schipma, Matthew J., Dumar, Zachary J., Joshi, Nikita R., Misharin, Alexander V., Embry, Ryan B., Fiore, Luciano, Gao, Peng, Diebold, Lauren P., McElroy, Gregory S., Shilatifard, Ali, Chandel, Navdeep S., Oliver, Guillermo

“…Mammalian retinal metabolism favors aerobic glycolysis. However, the role of glycolytic metabolism in retinal morphogenesis remains unknown. We report that…”
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Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma by Vo, BaoHan T., Li, Chunliang, Morgan, Marc A., Theurillat, Ilan, Finkelstein, David, Wright, Shaela, Hyle, Judith, Smith, Stephanie M.C., Fan, Yiping, Wang, Yong-Dong, Wu, Gang, Orr, Brent A., Northcott, Paul A., Shilatifard, Ali, Sherr, Charles J., Roussel, Martine F.

“…The most aggressive of four medulloblastoma (MB) subgroups are cMyc-driven group 3 (G3) tumors, some of which overexpress EZH2, the histone H3K27 mono-, di-,…”
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Blimp1/Prdm1 Functions in Opposition to Irf1 to Maintain Neonatal Tolerance during Postnatal Intestinal Maturation by Mould, Arne W, Morgan, Marc A J, Nelson, Andrew C, Bikoff, Elizabeth K, Robertson, Elizabeth J

“…The neonatal intestine is a very complex and dynamic organ that must rapidly adapt and remodel in response to a barrage of environmental stimuli during the…”
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Context dependency of Set1/COMPASS-mediated histone H3 Lys4 trimethylation by Thornton, Janet L, Westfield, Gerwin H, Takahashi, Yoh-Hei, Cook, Malcolm, Gao, Xin, Woodfin, Ashley R, Lee, Jung-Shin, Morgan, Marc A, Jackson, Jessica, Smith, Edwin R, Couture, Jean-Francois, Skiniotis, Georgios, Shilatifard, Ali

“…The stimulation of trimethylation of histone H3 Lys4 (H3K4) by H2B monoubiquitination (H2Bub) has been widely studied, with multiple mechanisms having been…”
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Mitochondrial respiration controls the Prox1-Vegfr3 feedback loop during lymphatic endothelial cell fate specification and maintenance by Ma, Wanshu, Gil, Hyea Jin, Liu, Xiaolei, Diebold, Lauren P, Morgan, Marc A, Oxendine-Burns, Michael J, Gao, Peng, Chandel, Navdeep S, Oliver, Guillermo

“…Recent findings indicate that mitochondrial respiration regulates blood endothelial cell proliferation; however, its role in differentiating lymphatic…”
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The PR/SET Domain Zinc Finger Protein Prdm4 Regulates Gene Expression in Embryonic Stem Cells but Plays a Nonessential Role in the Developing Mouse Embryo by Bogani, Debora, Morgan, Marc A. J., Nelson, Andrew C., Costello, Ita, McGouran, Joanna F., Kessler, Benedikt M., Robertson, Elizabeth J., Bikoff, Elizabeth K.

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An Mll4/COMPASS-Lsd1 epigenetic axis governs enhancer function and pluripotency transition in embryonic stem cells by Cao, Kaixiang, Collings, Clayton K, Morgan, Marc A, Marshall, Stacy A, Rendleman, Emily J, Ozark, Patrick A, Smith, Edwin R, Shilatifard, Ali

“…Chromatin regulators control cellular differentiation by orchestrating dynamic developmental gene expression programs, and hence, malfunctions in the…”
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Blimp-1/Prdm1 Alternative Promoter Usage during Mouse Development and Plasma Cell Differentiation by Morgan, Marc A. J., Magnusdottir, Erna, Kuo, Tracy C., Tunyaplin, Chai, Harper, James, Arnold, Sebastian J., Calame, Kathryn, Robertson, Elizabeth J., Bikoff, Elizabeth K.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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