Search Results - "Morgan, Marc"

Reevaluating the roles of histone-modifying enzymes and their associated chromatin modifications in transcriptional regulation by Morgan, Marc A. J., Shilatifard, Ali

“…Histone-modifying enzymes are implicated in the control of diverse DNA-templated processes including gene expression. Here, we outline historical and current…”
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Chromatin signatures of cancer by Morgan, Marc A, Shilatifard, Ali

“…Changes in the pattern of gene expression play an important role in allowing cancer cells to acquire their hallmark characteristics, while genomic instability…”
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The MLL3/MLL4 Branches of the COMPASS Family Function as Major Histone H3K4 Monomethylases at Enhancers by Hu, Deqing, Gao, Xin, Morgan, Marc A., Herz, Hans-Martin, Smith, Edwin R., Shilatifard, Ali

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Epigenetic moonlighting: Catalytic-independent functions of histone modifiers in regulating transcription by Morgan, Marc A J, Shilatifard, Ali

“…The past three decades have yielded a wealth of information regarding the chromatin regulatory mechanisms that control transcription. The "histone code"…”
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Inequality and Legitimacy: Past, Present and Future by Morgan, Marc

“…“…human societies cannot live without ideologies trying to make sense of their inequalities.” (1034) Thomas Piketty ends his latest book, Capital and Ideology,…”
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Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas by Piunti, Andrea, Hashizume, Rintaro, Morgan, Marc A, Bartom, Elizabeth T, Horbinski, Craig M, Marshall, Stacy A, Rendleman, Emily J, Ma, Quanhong, Takahashi, Yoh-hei, Woodfin, Ashley R, Misharin, Alexander V, Abshiru, Nebiyu A, Lulla, Rishi R, Saratsis, Amanda M, Kelleher, Neil L, James, C David, Shilatifard, Ali

“…Nucleosomes containing mutant K27M histones in diffuse intrinsic pediatric gliomas (DIPG) exclude PRC2 binding and recruit BET bromodomain proteins; however,…”
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Not All H3K4 Methylations Are Created Equal: Mll2/COMPASS Dependency in Primordial Germ Cell Specification by Hu, Deqing, Gao, Xin, Cao, Kaixiang, Morgan, Marc A., Mas, Gloria, Smith, Edwin R., Volk, Andrew G., Bartom, Elizabeth T., Crispino, John D., Di Croce, Luciano, Shilatifard, Ali

“…The spatiotemporal regulation of gene expression is central for cell-lineage specification during embryonic development and is achieved through the…”
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Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation by Douillet, Delphine, Sze, Christie C., Ryan, Caila, Piunti, Andrea, Shah, Avani P., Ugarenko, Michal, Marshall, Stacy A., Rendleman, Emily J., Zha, Didi, Helmin, Kathryn A., Zhao, Zibo, Cao, Kaixiang, Morgan, Marc A., Singer, Benjamin D., Bartom, Elizabeth T., Smith, Edwin R., Shilatifard, Ali

“…The COMPASS protein family catalyzes histone H3 Lys 4 (H3K4) methylation and its members are essential for regulating gene expression. MLL2/COMPASS methylates…”
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Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability by Rickels, Ryan, Herz, Hans-Martin, Sze, Christie C, Cao, Kaixiang, Morgan, Marc A, Collings, Clayton K, Gause, Maria, Takahashi, Yoh-hei, Wang, Lu, Rendleman, Emily J, Marshall, Stacy A, Krueger, Annika, Bartom, Elizabeth T, Piunti, Andrea, Smith, Edwin R, Abshiru, Nebiyu A, Kelleher, Neil L, Dorsett, Dale, Shilatifard, Ali

“…Ali Shilatifard and colleagues generate Drosophila lines expressing catalytically deficient Trr, which normally deposits H3K4me1 at enhancers. Trr mutants…”
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Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy by Wang, Lu, Zhao, Zibo, Ozark, Patrick A., Fantini, Damiano, Marshall, Stacy A., Rendleman, Emily J., Cozzolino, Kira A., Louis, Nundia, He, Xingyao, Morgan, Marc A., Takahashi, Yoh-hei, Collings, Clayton K., Smith, Edwin R., Ntziachristos, Panagiotis, Savas, Jeffrey N., Zou, Lihua, Hashizume, Rintaro, Meeks, Joshua J., Shilatifard, Ali

“…The lysine methyltransferase KMT2C (also known as MLL3), a subunit of the COMPASS complex, implements monomethylation of Lys4 on histone H3 (H3K4) at gene…”
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The Mll2 branch of the COMPASS family regulates bivalent promoters in mouse embryonic stem cells by Hu, Deqing, Garruss, Alexander S, Gao, Xin, Morgan, Marc A, Cook, Malcolm, Smith, Edwin R, Shilatifard, Ali

“…Embryonic stem cells (ESCs) possess a unique chromatin landscape in which 'bivalent' domains of trimethylated histone H3 Lys4 (H3K4me3) and Lys27 (H3K27me3)…”
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Epigenetic ConFUSION: SS18-SSX Fusion Rewires BAF Complex to Activate Bivalent Genes in Synovial Sarcoma by Morgan, Marc A., Shilatifard, Ali

“…In this issue of Cancer Cell, McBride and colleagues report that the synovial sarcoma SS18-SSX fusion drives BAF complex recruitment to bivalent domains…”
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A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation by Morgan, Marc A J, Rickels, Ryan A, Collings, Clayton K, He, Xiaolin, Cao, Kaixiang, Herz, Hans-Martin, Cozzolino, Kira A, Abshiru, Nebiyu A, Marshall, Stacy A, Rendleman, Emily J, Sze, Christie C, Piunti, Andrea, Kelleher, Neil L, Savas, Jeffrey N, Shilatifard, Ali

“…Histone H3 Lys4 (H3K4) methylation is a chromatin feature enriched at gene -regulatory sequences such as promoters and enhancers. Here we identify an…”
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Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta by Mould, Arne, Morgan, Marc A J, Li, Li, Bikoff, Elizabeth K, Robertson, Elizabeth J

“…Developmental arrest of Blimp1/Prdm1 mutant embryos at around embryonic day 10.5 (E10.5) has been attributed to placental disturbances. Here we investigate…”
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Blimp1/Prdm1 Functions in Opposition to Irf1 to Maintain Neonatal Tolerance during Postnatal Intestinal Maturation by Mould, Arne W, Morgan, Marc A J, Nelson, Andrew C, Bikoff, Elizabeth K, Robertson, Elizabeth J

“…The neonatal intestine is a very complex and dynamic organ that must rapidly adapt and remodel in response to a barrage of environmental stimuli during the…”
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Histone H3K4 methylation-dependent and -independent functions of Set1A/COMPASS in embryonic stem cell self-renewal and differentiation by Sze, Christie C, Cao, Kaixiang, Collings, Clayton K, Marshall, Stacy A, Rendleman, Emily J, Ozark, Patrick A, Chen, Fei Xavier, Morgan, Marc A, Wang, Lu, Shilatifard, Ali

“…Of the six members of the COMPASS (complex of proteins associated with Set1) family of histone H3 Lys4 (H3K4) methyltransferases identified in mammals, Set1A…”
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A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer by Morgan, Marc A J, Popova, Irina K, Vaidya, Anup, Burg, Jonathan M, Marunde, Matthew R, Rendleman, Emily J, Dumar, Zachary J, Watson, Rachel, Meiners, Matthew J, Howard, Sarah A, Khalatyan, Natalia, Vaughan, Robert M, Rothbart, Scott B, Keogh, Michael-C, Shilatifard, Ali

“…Mutations in the chromatin regulator cause the human neurodevelopmental disorder Chung-Jansen syndrome, while alterations in expression are linked to cancer…”
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Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling by Herz, Hans-Martin, Morgan, Marc, Gao, Xin, Jackson, Jessica, Rickels, Ryan, Swanson, Selene K., Florens, Laurence, Washburn, Michael P., Eissenberg, Joel C., Shilatifard, Ali

“…Histone H3 lysine27-to-methionine (H3K27M) gain-of-function mutations occur in highly aggressive pediatric gliomas. We established a Drosophila animal model…”
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A DNA damage–induced phosphorylation circuit enhances Mec1ATR Ddc2ATRIP recruitment to Replication Protein A by Yates, Luke A, Tannous, Elias A, Morgan, R Marc, Burgers, Peter M, Zhang, Xiaodong

“…The cell cycle checkpoint kinase Mec1ATR and its integral partner Ddc2ATRIP are vital for the DNA damage and replication stress response. Mec1–Ddc2 "senses"…”
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Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life by Elias, Salah, Morgan, Marc A., Bikoff, Elizabeth K., Robertson, Elizabeth J.

“…The hierarchical relationships between various stem and progenitor cell subpopulations driving mammary gland morphogenesis and homoeostasis are poorly…”
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