Search Results - "Morgan, Joshua"

Why not connectomics? by Morgan, Joshua L, Lichtman, Jeff W

“…Opinions diverge on whether mapping the synaptic connectivity of the brain is a good idea. Here we argue that albeit their limitations, such maps will reveal…”
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Dexamethasone Stiffens Trabecular Meshwork, Trabecular Meshwork Cells, and Matrix by Raghunathan, Vijay Krishna, Morgan, Joshua T, Park, Shin Ae, Weber, Darren, Phinney, Brett S, Murphy, Christopher J, Russell, Paul

“…Treatment with corticosteroids can result in ocular hypertension and may lead to the development of steroid-induced glaucoma. The extent to which biomechanical…”
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In vitro formation and extended culture of highly metabolically active and contractile tissues by Bagdasarian, Isabella A, Tonmoy, Thamidul Islam, Park, B. Hyle, Morgan, Joshua T

“…3D cell culture models have gained popularity in recent years as an alternative to animal and 2D cell culture models for pharmaceutical testing and disease…”
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Organization of the gravity-sensing system in zebrafish by Liu, Zhikai, Hildebrand, David G. C., Morgan, Joshua L., Jia, Yizhen, Slimmon, Nicholas, Bagnall, Martha W.

“…Motor circuits develop in sequence from those governing fast movements to those governing slow. Here we examine whether upstream sensory circuits are organized…”
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Development of Cell Type-Specific Connectivity Patterns of Converging Excitatory Axons in the Retina by Morgan, Joshua L., Soto, Florentina, Wong, Rachel O.L., Kerschensteiner, Daniel

“…To integrate information from different presynaptic cell types, dendrites receive distinct patterns of synapses from converging axons. How different afferents…”
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Fabrication of centimeter-scale and geometrically arbitrary vascular networks using in vitro self-assembly by Morgan, Joshua T., Shirazi, Jasmine, Comber, Erica M., Eschenburg, Christian, Gleghorn, Jason P.

“…One of the largest challenges facing the field of tissue engineering is the incorporation of a functional vasculature, allowing effective nourishment of graft…”
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The tardigrade-derived mitochondrial abundant heat soluble protein improves adipose-derived stem cell survival against representative stressors by Rolsma, Jordan L., Darch, William, Higgins, Nicholas C., Morgan, Joshua T.

“…Human adipose-derived stem cell (ASC) grafts have emerged as a powerful tool in regenerative medicine. However, ASC therapeutic potential is hindered by…”
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Development of a Rigorous Modeling Framework for Solvent-Based CO2 Capture. Part 2: Steady-State Validation and Uncertainty Quantification with Pilot Plant Data by Morgan, Joshua C, Soares Chinen, Anderson, Omell, Benjamin, Bhattacharyya, Debangsu, Tong, Charles, Miller, David C, Buschle, Bill, Lucquiaud, Mathieu

“…The U.S. DOE’s Carbon Capture Simulation Initiative (CCSI) has a strong focus on the development of state of the art process models for accelerating the…”
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Dexamethasone Impairs ATP Production and Mitochondrial Performance in Human Trabecular Meshwork Cells by Kennedy, Shane, Williams, Clayton, Tsaturian, Emily, Morgan, Joshua T

“…Mitochondrial damage occurs in human trabecular meshwork (HTM) cells as a result of normal aging and in open angle glaucoma. Using an HTM cell model, we…”
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Automated epidermal thickness quantification of in vitro human skin equivalents using optical coherence tomography by Sanchez, Martina M, Orneles, Danielle N, Park, B Hyle, Morgan, Joshua T

“…Human skin equivalents (HSEs) are models of human skin. They are used to study skin development, diseases, wound healing and toxicity. The gold standard of…”
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Organotypic cultures as aging associated disease models by Sanchez, Martina M, Bagdasarian, Isabella A, Darch, William, Morgan, Joshua T

“…Aging remains a primary risk factor for a host of diseases, including leading causes of death. Aging and associated diseases are inherently multifactorial,…”
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Uncertainty quantification of property models: Methodology and its application to CO2-loaded aqueous MEA solutions by Morgan, Joshua C., Bhattacharyya, Debangsu, Tong, Charles, Miller, David C.

“…Uncertainties in property models can significantly affect the results obtained from process simulations. If these uncertainties are not quantified, optimal…”
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Central Vestibular Tuning Arises from Patterned Convergence of Otolith Afferents by Liu, Zhikai, Kimura, Yukiko, Higashijima, Shin-ichi, Hildebrand, David G.C., Morgan, Joshua L., Bagnall, Martha W.

“…As sensory information moves through the brain, higher-order areas exhibit more complex tuning than lower areas. Though models predict that complexity arises…”
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Thermodynamic modeling and uncertainty quantification of CO2-loaded aqueous MEA solutions by Morgan, Joshua C., Chinen, Anderson Soares, Omell, Benjamin, Bhattacharyya, Debangsu, Tong, Charles, Miller, David C.

“…•Thermodynamic model of MEA system developed with uncertainty quantification.•Reaction kinetics should be consistent with thermodynamic model for…”
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Involvement of YAP, TAZ and HSP90 in contact guidance and intercellular junction formation in corneal epithelial cells by Raghunathan, Vijay Krishna, Dreier, Britta, Morgan, Joshua T, Tuyen, Binh C, Rose, Brad W, Reilly, Christopher M, Russell, Paul, Murphy, Christopher J

“…The extracellular environment possesses a rich milieu of biophysical and biochemical signaling cues that are simultaneously integrated by cells and influence…”
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Substratum stiffness and latrunculin B modulate the gene expression of the mechanotransducers YAP and TAZ in human trabecular meshwork cells by Thomasy, Sara M., Morgan, Joshua T., Wood, Joshua A., Murphy, Christopher J., Russell, Paul

“…The compliance of the human trabecular meshwork (HTM) has been shown to dramatically stiffen in glaucomatous patients. The purpose of this study was to…”
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Increased AMP deaminase activity decreases ATP content and slows protein degradation in cultured skeletal muscle by Davis, Patrick R., Miller, Spencer G., Verhoeven, Nicolas A., Morgan, Joshua S., Tulis, David A., Witczak, Carol A., Brault, Jeffrey J.

“…Protein degradation is an energy-dependent process, requiring ATP at multiple steps. However, reports conflict as to the relationship between intracellular…”
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Development of a Rigorous Modeling Framework for Solvent-Based CO2 Capture. 1. Hydraulic and Mass Transfer Models and Their Uncertainty Quantification by Soares Chinen, Anderson, Morgan, Joshua C, Omell, Benjamin, Bhattacharyya, Debangsu, Tong, Charles, Miller, David C

“…Rigorous process models are critical for reducing the risk and uncertainty of scaling up a new technology. It is essential to quantify uncertainty in key…”
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Uncertainty analysis in the techno-economic assessment of CO2 capture and storage technologies. Critical review and guidelines for use by van der Spek, Mijndert, Fout, Timothy, Garcia, Monica, Kuncheekanna, Vishalini Nair, Matuszewski, Michael, McCoy, Sean, Morgan, Joshua, Nazir, Shareq Mohd, Ramirez, Andrea, Roussanaly, Simon, Rubin, Edward S.

“…•Sound uncertainty analysis is indispensable to CCS techno-economic analysis and its communication.•Many different uncertainty analysis methods exist, all with…”
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What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease by Morgan, Joshua T., Murphy, Christopher J., Russell, Paul

“…Cells in vivo are exposed to a complex signaling environment. Biochemical signaling modalities, such as secreted proteins, specific extracellular matrix…”
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