Search Results - "Morgan, Jeremy"

Extensive protein pyrophosphorylation revealed in human cell lines by Morgan, Jeremy A. M., Singh, Arpita, Kurz, Leonie, Nadler-Holly, Michal, Ruwolt, Max, Ganguli, Shubhra, Sharma, Sheenam, Penkert, Martin, Krause, Eberhard, Liu, Fan, Bhandari, Rashna, Fiedler, Dorothea

“…Reversible protein phosphorylation is a central signaling mechanism in eukaryotes. Although mass-spectrometry-based phosphoproteomics has become routine,…”
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Palladium‐Catalyzed Construction of Quaternary Stereocenters by Enantioselective Arylation of γ‐Lactams with Aryl Chlorides and Bromides by Jette, Carina I., Geibel, Irina, Bachman, Shoshana, Hayashi, Masaki, Sakurai, Shunya, Shimizu, Hideki, Morgan, Jeremy B., Stoltz, Brian M.

“…Herein, we report the first Pd‐catalyzed enantioselective arylation of α‐substituted γ‐lactams. Two sets of conditions were developed for this transformation,…”
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Synthesis of β-substituted tryptamines by regioselective ring opening of aziridines by Kidd, Jesse, Maiden, Kristen, Morgan, Jeremy B.

“…Functionalized tryptamines are targets of interest for development as small molecule therapeutics. The ring opening of aziridines with indoles is a powerful…”
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Detection of Biosynthetic Precursors, Discovery of Glycosylated Forms, and Homeostasis of Calcitonin in Human Cancer Cells by Cao, Feihua, Gamble, Allan B, Onagi, Hideki, Howes, Joanna, Hennessy, James E, Gu, Chen, Morgan, Jeremy A. M, Easton, Christopher J

“…The peptide hormone calcitonin is intimately connected with human cancer development and proliferation. Its biosynthesis is reasoned to proceed via glycine-,…”
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Palladium-Catalyzed, Enantioselective Desymmetrization of N‑Acylaziridines with Indoles by Van Hecke, Kinney, Benton, Tyler R, Casper, Michael, Mauldin, Dustin, Drake, Brandon, Morgan, Jeremy B

“…Ring opening reactions of meso-aziridines generate chiral amine derivatives where the control of stereochemistry is possible through enantioselective…”
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Enantioselective Synthesis and Stereoselective Ring Opening of N-Acylaziridines by Cockrell, Jennifer, Wilhelmsen, Christopher, Rubin, Heather, Martin, Allen, Morgan, Jeremy B.

“…Kinetic resolution of N‐acylaziridines by nucleophilic ring opening was achieved with (R)‐BINOL as the chiral modifier under boron‐catalyzed conditions (see…”
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Palladium-Catalyzed, Enantioselective Heine Reaction by Punk, Molly, Merkley, Charlotte, Kennedy, Katlyn, Morgan, Jeremy B

“…Aziridines are important synthetic intermediates for the generation of nitrogen-containing molecules. N-Acylaziridines undergo rearrangement by ring expansion…”
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Cannabicitran: Its unexpected racemic nature and potential origins by Wood, Jared S., Gordon, William H., Morgan, Jeremy B., Williamson, R. Thomas

“…Cannabicitran is a cannabinoid found in levels up to ~10% in commercial “purified” cannabidiol (CBD) extracts. The structure of this natural product was first…”
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Pyrophosphorylation via selective phosphoprotein derivatization by Marmelstein, Alan M, Morgan, Jeremy A M, Penkert, Martin, Rogerson, Daniel T, Chin, Jason W, Krause, Eberhard, Fiedler, Dorothea

“…An important step in elucidating the function of protein post-translational modifications (PTMs) is gaining access to site-specifically modified, homogeneous…”
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A murine model of variant late infantile ceroid lipofuscinosis recapitulates behavioral and pathological phenotypes of human disease by Morgan, Jeremy P, Magee, Helen, Wong, Andrew, Nelson, Tarah, Koch, Bettina, Cooper, Jonathan D, Weimer, Jill M

“…Neuronal ceroid lipofuscinoses (NCLs; also known collectively as Batten Disease) are a family of autosomal recessive lysosomal storage disorders. Mutations in…”
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Enantiospecific Synthesis of β‑Substituted Tryptamines by Rubin, Heather N, Van Hecke, Kinney, Mills, Jonathan J, Cockrell, Jennifer, Morgan, Jeremy B

“…Functionalized tryptamines are targets of interest for development as small molecule therapeutics. The ring opening of aziridines with indoles is a powerful…”
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Scalable Synthesis of N‑Acylaziridines from N‑Tosylaziridines by Rubin, Heather, Cockrell, Jennifer, Morgan, Jeremy B

“…N-Acylaziridines are important starting materials for the synthesis of chiral amine derivatives. The traditional methods for producing these activated…”
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Calculated and experimental 1H and 13C NMR assignments for cannabicitran by Wood, Jared S., Gordon, William H., Morgan, Jeremy B., Williamson, R. Thomas

“…Cannabicitran is an important cannabinoid natural product produced by Cannabis sativa and is often found at surprisingly high levels (up to ~10%) in “purified”…”
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Calculated and experimental 1 H and 13 C NMR assignments for cannabicitran by Wood, Jared S, Gordon, William H, Morgan, Jeremy B, Williamson, R Thomas

“…Cannabicitran is an important cannabinoid natural product produced by Cannabis sativa and is often found at surprisingly high levels (up to ~10%) in "purified"…”
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Quinine-Promoted, Enantioselective Boron-Tethered Diels–Alder Reaction by Anomeric Control of Transition-State Conformation by Scholl, Katie, Dillashaw, John, Timpy, Evan, Lam, Yu-hong, DeRatt, Lindsey, Benton, Tyler R, Powell, Jacqueline P, Houk, K. N, Morgan, Jeremy B

“…Diels–Alder reactions of tethered vinyl–metal species offer the opportunity to fashion highly functionalized diol intermediates for synthesis. We have…”
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Phosphine-Catalyzed Heine Reaction by Martin, Allen, Casto, Kathleen, Morris, William, Morgan, Jeremy B

“…Aziridines are important synthetic intermediates which readily undergo ring-opening reactions. It is demonstrated that electron-rich phosphines are efficient…”
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Investigating the activity of quinine analogues versus chloroquine resistant Plasmodium falciparum by Dinio, Theresa, Gorka, Alexander P., McGinniss, Andrew, Roepe, Paul D., Morgan, Jeremy B.

“…Plasmodium falciparum, the deadliest malarial parasite species, has developed resistance against nearly all man-made antimalarial drugs within the past…”
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Rh-Catalyzed Enantioselective Diboration of Simple Alkenes:  Reaction Development and Substrate Scope by Trudeau, Stéphane, Morgan, Jeremy B, Shrestha, Mohanish, Morken, James P

“…The rhodium-catalyzed reaction between bis(catecholato)diboron and simple alkenes results in the syn addition of the diboron across the alkene. The resulting…”
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Occurrence of the artificial sweetener sucralose in coastal and marine waters of the United States by Mead, Ralph N., Morgan, Jeremy B., Avery, G. Brooks, Kieber, Robert J., Kirk, Aleksandra M., Skrabal, Stephan A., Willey, Joan D.

“…The first concentration data for the artificial sweetener sucralose (Splenda ®) is presented for North American coastal and open ocean waters. Large volume…”
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Photodegradation of the antihistamine cetirizine in natural waters by Mead, Ralph N, Barefoot, Seth, Helms, John R, Morgan, Jeremy B, Kieber, Robert J

“…The photodegradation rate of the anti‐histamine cetirizine (Zyrtec®) was investigated in various water matrices. The average observed first‐order…”
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