Search Results - "Morgan, G. R."

Targeting LGR5 in Colorectal Cancer: therapeutic gold or too plastic? by Morgan, RG, Mortensson, E, Williams, AC

“…Leucine-rich repeat-containing G-protein coupled receptor (LGR5 or GPR49) potentiates canonical Wnt/β-catenin signalling and is a marker of normal stem cells…”
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Interrogation of the human cortical peptidome uncovers cell-type specific signatures of cognitive resilience against Alzheimer’s disease by Morgan, G. R., Carlyle, B. C.

“…Alzheimer’s disease (AD) is characterised by age-related cognitive decline. Brain accumulation of amyloid-β plaques and tau tangles is required for a…”
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Scramjets and shock tunnels—The Queensland experience by Stalker, R.J., Paull, A., Mee, D.J, Morgan, R.G., Jacobs, P.A.

“…This article reports on the use of a shock tunnel to study the operation of scramjet powered configurations at sub-orbital velocities above 2 km/s. Thrust, as…”
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Implementation of a state-to-state analytical framework for the calculation of expansion tube flow properties by James, C. M., Gildfind, D. E., Lewis, S. W., Morgan, R. G., Zander, F.

“…Expansion tubes are an important type of test facility for the study of planetary entry flow-fields, being the only type of impulse facility capable of…”
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LGR5 expression is regulated by EGF in early colorectal adenomas and governs EGFR inhibitor sensitivity by Morgan, R G, Mortensson, E, Legge, D N, Gupta, B, Collard, T J, Greenhough, A, Williams, A C

“…Background: LGR5 serves as a co-receptor for Wnt/ β -catenin signalling and marks normal intestinal stem cells; however, its role in colorectal cancer (CRC)…”
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Optimized delivery of siRNA into 3D tumor spheroid cultures in situ by Morgan, R. G., Chambers, A. C., Legge, D. N., Coles, S. J., Greenhough, A., Williams, A. C.

“…3D tissue culture provides a physiologically relevant and genetically tractable system for studying normal and malignant human tissues. Despite this,…”
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Expansion tube nozzle design using a parallel simplex algorithm by Toniato, P., Gildfind, D. E., Jacobs, P. A., Morgan, R. G.

“…A new hypersonic Mach 12 nozzle has been designed and manufactured for a large-scale expansion tube. The nozzle design goals were to produce a Mach 12 flow,…”
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The effect of increased throat size on the nozzle-supply flow in reflected shock tunnels by Whitside, R. W., Chan, W. Y. K., Smart, M. K., Morgan, R. G.

“…The operation of free-piston-driven reflected shock tunnels has largely observed the rule of thumb that the nozzle throat diameter should not exceed one third…”
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Prosthetic joint infection of the knee - arthroscopic biopsy identifies more and different organisms than aspiration alone by Clarke, Michael J.H., Salar, Omer, Evans, Jonathan P., Bayley, Morgan G.R., Waterson, Ben H., Toms, Andrew D., Phillips, Jonathan R.A.

“…•A combination of aspiration and biopsy is superior to biopsy or aspiration alone for TKR PJI diagnosis.•Results from biopsy are superior to aspiration alone…”
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Scramjet test flow reconstruction for a large-scale expansion tube, Part 2: axisymmetric CFD analysis by Gildfind, D. E., Jacobs, P. A., Morgan, R. G., Chan, W. Y. K., Gollan, R. J.

“…This paper presents the second part of a study aiming to accurately characterise a Mach 10 scramjet test flow generated using a large free-piston-driven…”
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γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin by Morgan, R G, Pearn, L, Liddiard, K, Pumford, S L, Burnett, A K, Tonks, A, Darley, R L

“…Canonical Wnt signaling regulates the transcription of T-cell factor (TCF)-responsive genes through the stabilization and nuclear translocation of the…”
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MR Imaging as the Sole Preoperative Imaging Modality for Right Hepatectomy: A Prospective Study of Living Adult-to-Adult Liver Donor Candidates by Lee, Vivian S, Morgan, Glyn R, Teperman, Lewis W, John, Devon, Diflo, Thomas, Pandharipande, Pari V, Berman, Phil M, Lavelle, Michael T, Krinsky, Glenn A, Rofsky, Neil M, Schlossberg, Peter, Weinreb, Jeffrey C

“…Our aim was to investigate the feasibility of MR imaging as a comprehensive preoperative imaging test for examination of liver donor candidates for…”
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Scramjet test flow reconstruction for a large-scale expansion tube, Part 1: quasi-one-dimensional modelling by Gildfind, D. E., Jacobs, P. A., Morgan, R. G., Chan, W. Y. K., Gollan, R. J.

“…Large-scale free-piston driven expansion tubes have uniquely high total pressure capabilities which make them an important resource for development of…”
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Using optically filtered high-speed imaging to characterise expansion tube operating conditions by James, C. M., Smith, D. R., McLean, C., Morgan, R. G., Lewis, S. W., Toniato, P., Wei, H., McIntyre, T. J.

“…Traditionally, Pitot rake test models have been used to take time- and spatially resolved impact pressure measurements in impulse facilities for flow…”
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Volumetric mangafodipir trisodium-enhanced cholangiography to define intrahepatic biliary anatomy by LEE, Vivian S, ROFSKY, Neil M, MORGAN, Glyn R, TEPERMAN, Lewis W, KRINSKY, Glenn A, BERMAN, Phil, WEINREB, Jeffrey C

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Treatment of Lymphedema of the Arms and Legs with 5,6-Benzo-[alpha]-pyrone by Casley-Smith, John R, Morgan, Robert Gwyn, Piller, Neil B

“…Lymphedema, a form of high-protein edema, is a serious, long-lasting, and common problem; there are about 140 million cases throughout the world 1 , 2 …”
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A new sliding joint to accommodate recoil of a free-piston-driven expansion tube facility by Gildfind, D. E., Morgan, R. G.

“…This paper describes a new device to decouple free-piston driver recoil and its associated mechanical vibration from the acceleration tube and test section of…”
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Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: implications for targeting cancer stem cells by Morgan, R G, Molnár, E, Jones, R F, Collard, T J, Lane, J D, Greenhough, A, Paraskeva, C, Williams, A C

“…Background: LGR5 is an important marker of intestinal stem cells and performs its vital functions at the cell membrane. Despite the importance of LGR5 to both…”
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Quality evaluation of clinical records of a group of general dental practitioners entering a quality assurance programme by Morgan, R G

“…This paper discusses the importance of maintaining high quality clinical records. Evidence from studies carried out in the USA, Australia and Scandinavia shows…”
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Characterization of cognitive impairments and neurotransmitter changes in a novel transgenic mouse lacking Slc10a4 by Melief, E.J, Gibbs, J.T, Li, X, Morgan, R.G, Keene, C.D, Montine, T.J, Palmiter, R.D, Darvas, M

“…Highlights • Slc10a4 expression is enriched in midbrain and brainstem regions. • Slc10a4Δ/Δ mice have moderate impairment in spatial learning and cognitive…”
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