Search Results - "Morgan, Claire C."

Population Genomics Reveal Recent Speciation and Rapid Evolutionary Adaptation in Polar Bears by Liu, Shiping, Lorenzen, Eline D., Fumagalli, Matteo, Li, Bo, Harris, Kelley, Xiong, Zijun, Zhou, Long, Korneliussen, Thorfinn Sand, Somel, Mehmet, Babbitt, Courtney, Wray, Greg, Li, Jianwen, He, Weiming, Wang, Zhuo, Fu, Wenjing, Xiang, Xueyan, Morgan, Claire C., Doherty, Aoife, O’Connell, Mary J., McInerney, James O., Born, Erik W., Dalén, Love, Dietz, Rune, Orlando, Ludovic, Sonne, Christian, Zhang, Guojie, Nielsen, Rasmus, Willerslev, Eske, Wang, Jun

“…Polar bears are uniquely adapted to life in the High Arctic and have undergone drastic physiological changes in response to Arctic climates and a hyperlipid…”
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Changes in the Coding and Non-coding Transcriptome and DNA Methylome that Define the Schwann Cell Repair Phenotype after Nerve Injury by Arthur-Farraj, Peter J., Morgan, Claire C., Adamowicz, Martyna, Gomez-Sanchez, Jose A., Fazal, Shaline V., Beucher, Anthony, Razzaghi, Bonnie, Mirsky, Rhona, Jessen, Kristjan R., Aitman, Timothy J.

“…Repair Schwann cells play a critical role in orchestrating nerve repair after injury, but the cellular and molecular processes that generate them are poorly…”
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Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension by Sindi, Hebah A., Russomanno, Giusy, Satta, Sandro, Abdul-Salam, Vahitha B., Jo, Kyeong Beom, Qazi-Chaudhry, Basma, Ainscough, Alexander J., Szulcek, Robert, Jan Bogaard, Harm, Morgan, Claire C., Pullamsetti, Soni S., Alzaydi, Mai M., Rhodes, Christopher J., Piva, Roberto, Eichstaedt, Christina A., Grünig, Ekkehard, Wilkins, Martin R., Wojciak-Stothard, Beata

“…Pulmonary arterial hypertension (PAH) is a severe disorder of lung vasculature that causes right heart failure. Homoeostatic effects of flow-activated…”
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Molecular evolution of mammalian genes with epistatic interactions in fertilization by Morgan, Claire C, Hart, Michael W

“…Genes that encode proteins associated with sperm competition, fertilization, and sexual conflicts of interest are often among the most rapidly evolving parts…”
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Author Correction: Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension by Sindi, Hebah A., Russomanno, Giusy, Satta, Sandro, Abdul-Salam, Vahitha B., Jo, Kyeong Beom, Qazi-Chaudhry, Basma, Ainscough, Alexander J., Szulcek, Robert, Bogaard, Harm Jan, Morgan, Claire C., Pullamsetti, Soni S., Alzaydi, Mai M., Rhodes, Christopher J., Piva, Roberto, Eichstaedt, Christina A., Grünig, Ekkehard, Wilkins, Martin R., Wojciak-Stothard, Beata

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Erratum to: Positive selection neighboring functionally essential sites and disease-implicated regions of mammalian reproductive proteins by Morgan, Claire C, Loughran, Noeleen B, Walsh, Thomas A, Harrison, Alan J, O'Connell, Mary J

“…After publication of the original article [1] the authors found that all instances of the protein SP56 should have been referred to as SELENBP1 in the article…”
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Molecular adaptation of telomere associated genes in mammals by Morgan, Claire C, Mc Cartney, Ann M, Donoghue, Mark T A, Loughran, Noeleen B, Spillane, Charles, Teeling, Emma C, O'Connell, Mary J

“…Placental mammals display a huge range of life history traits, including size, longevity, metabolic rate and germ line generation time. Although a number of…”
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Colon cancer associated genes exhibit signatures of positive selection at functionally significant positions by Morgan, Claire C, Shakya, Kabita, Webb, Andrew, Walsh, Thomas A, Lynch, Mark, Loscher, Christine E, Ruskin, Heather J, O'Connell, Mary J

“…Cancer, much like most human disease, is routinely studied by utilizing model organisms. Of these model organisms, mice are often dominant. However, our…”
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Positive selection neighboring functionally essential sites and disease-implicated regions of mammalian reproductive proteins by Morgan, Claire C, Loughran, Noeleen B, Walsh, Thomas A, Harrison, Alan J, O'Connell, Mary J

“…Reproductive proteins are central to the continuation of all mammalian species. The evolution of these proteins has been greatly influenced by environmental…”
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Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes by Miguel-Escalada, Irene, Bonàs-Guarch, Silvia, Cebola, Inês, Ponsa-Cobas, Joan, Mendieta-Esteban, Julen, Atla, Goutham, Javierre, Biola M., Rolando, Delphine M. Y., Farabella, Irene, Morgan, Claire C., García-Hurtado, Javier, Beucher, Anthony, Morán, Ignasi, Pasquali, Lorenzo, Ramos-Rodríguez, Mireia, Appel, Emil V. R., Linneberg, Allan, Gjesing, Anette P., Witte, Daniel R., Pedersen, Oluf, Grarup, Niels, Ravassard, Philippe, Torrents, David, Mercader, Josep M., Piemonti, Lorenzo, Berney, Thierry, de Koning, Eelco J. P., Kerr-Conte, Julie, Pattou, François, Fedko, Iryna O., Groop, Leif, Prokopenko, Inga, Hansen, Torben, Marti-Renom, Marc A., Fraser, Peter, Ferrer, Jorge

“…Genetic studies promise to provide insight into the molecular mechanisms underlying type 2 diabetes (T2D). Variants associated with T2D are often located in…”
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A Guide to Phylogenetic Reconstruction Using Heterogeneous Models—A Case Study from the Root of the Placental Mammal Tree by Moran, Raymond J, Morgan, Claire C, O'Connell, Mary J

“…There are numerous phylogenetic reconstruction methods and models available-but which should you use and why? Important considerations in phylogenetic analyses…”
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Heterogeneous models place the root of the placental mammal phylogeny by Morgan, Claire C, Foster, Peter G, Webb, Andrew E, Pisani, Davide, McInerney, James O, O'Connell, Mary J

“…Heterogeneity among life traits in mammals has resulted in considerable phylogenetic conflict, particularly concerning the position of the placental root…”
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Paternally Expressed Imprinted Genes under Positive Darwinian Selection in Arabidopsis thaliana by Tuteja, Reetu, McKeown, Peter C, Ryan, Pat, Morgan, Claire C, Donoghue, Mark T A, Downing, Tim, O'Connell, Mary J, Spillane, Charles

“…Genomic imprinting is an epigenetic phenomenon where autosomal genes display uniparental expression depending on whether they are maternally or paternally…”
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Adaptive Evolution as a Predictor of Species-Specific Innate Immune Response by Webb, Andrew E, Gerek, Z Nevin, Morgan, Claire C, Walsh, Thomas A, Loscher, Christine E, Edwards, Scott V, O'Connell, Mary J

“…It has been proposed that positive selection may be associated with protein functional change. For example, human and macaque have different outcomes to HIV…”
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Mitochondrial data are not suitable for resolving placental mammal phylogeny by Morgan, Claire C, Creevey, Christopher J, O’Connell, Mary J

“…Mitochondrial data have traditionally been used in reconstructing a variety of species phylogenies. The low rates of recombination and thorough…”
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Functionally Conserved Noncoding Regulators of Cardiomyocyte Proliferation and Regeneration in Mouse and Human by Adamowicz, Martyna, Morgan, Claire C, Haubner, Bernhard J, Noseda, Michela, Collins, Melissa J, Abreu Paiva, Marta, Srivastava, Prashant K, Gellert, Pascal, Razzaghi, Bonnie, O'Gara, Peter, Raina, Priyanka, Game, Laurence, Bottolo, Leonardo, Schneider, Michael D, Harding, Sian E, Penninger, Josef, Aitman, Timothy J

“…The adult mammalian heart has little regenerative capacity after myocardial infarction (MI), whereas neonatal mouse heart regenerates without scarring or…”
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Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes by Bonàs Guarch, Sílvia, Guindo-Martínez, Marta, Miguel-Escalada, Irene, Grarup, Niels, Sebastián Muñoz, David, Rodriguez-Fos, Elias, Sánchez, Friman, Planas-Fèlix, Mercè, Cortes-Sánchez, Paula, González, Santi, Timshel, Pascal, Pers, Tune H, Morgan, Claire C, Moran, Ignasi, Atla, Goutham, González, Juan Ramón, Puiggros, Montserrat, Martí, Jonathan, Andersson, Ehm A, Díaz, Carlos, Badia, Rosa M, Udler, Miriam, Leong, Aaron, Kaur, Varindepal, Flannick, Jason, Jørgensen, Torben, Linneberg, Allan, Jørgensen, Marit E, Witte, Daniel R, Christensen, Cramer, Brandslund, Ivan, Appel, Emil V, Scott, Robert A, Luan, Jian'an, Langenberg, Claudia, Wareham, Nicholas J, Pedersen, Oluf, Zorzano Olarte, Antonio, Florez, Jose C, Hansen, Torben

“…The reanalysis of existing GWAS data represents a powerful and cost-effective opportunity to gain insights into the genetics of complex diseases. By…”
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Publisher Correction: Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes by Bonàs-Guarch, Sílvia, Guindo-Martínez, Marta, Miguel-Escalada, Irene, Grarup, Niels, Sebastian, David, Rodriguez-Fos, Elias, Sánchez, Friman, Planas-Fèlix, Mercè, Cortes-Sánchez, Paula, González, Santi, Timshel, Pascal, Pers, Tune H., Morgan, Claire C., Moran, Ignasi, Atla, Goutham, González, Juan R., Puiggros, Montserrat, Martí, Jonathan, Andersson, Ehm A., Díaz, Carlos, Badia, Rosa M., Udler, Miriam, Leong, Aaron, Kaur, Varindepal, Flannick, Jason, Jørgensen, Torben, Linneberg, Allan, Jørgensen, Marit E., Witte, Daniel R., Christensen, Cramer, Brandslund, Ivan, Appel, Emil V., Scott, Robert A., Luan, Jian’an, Langenberg, Claudia, Wareham, Nicholas J., Pedersen, Oluf, Zorzano, Antonio, Florez, Jose C, Hansen, Torben, Ferrer, Jorge, Mercader, Josep Maria, Torrents, David

“…In the originally published version of this Article, the affiliation details for Santi González, Jian’an Luan and Claudia Langenberg were inadvertently…”
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Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes by Bonàs-Guarch, Sílvia, Guindo-Martínez, Marta, Miguel-Escalada, Irene, Grarup, Niels, Sebastian, David, Rodriguez-Fos, Elias, Sánchez, Friman, Planas-Fèlix, Mercè, Cortes-Sánchez, Paula, González, Santi, Timshel, Pascal, Pers, Tune H., Morgan, Claire C., Moran, Ignasi, Atla, Goutham, González, Juan R., Puiggros, Montserrat, Martí, Jonathan, Andersson, Ehm A., Díaz, Carlos, Badia, Rosa M., Udler, Miriam, Leong, Aaron, Kaur, Varindepal, Flannick, Jason, Jørgensen, Torben, Linneberg, Allan, Jørgensen, Marit E., Witte, Daniel R., Christensen, Cramer, Brandslund, Ivan, Appel, Emil V., Scott, Robert A., Luan, Jian’an, Langenberg, Claudia, Wareham, Nicholas J., Pedersen, Oluf, Zorzano, Antonio, Florez, Jose C, Hansen, Torben, Ferrer, Jorge, Mercader, Josep Maria, Torrents, David

“…The reanalysis of existing GWAS data represents a powerful and cost-effective opportunity to gain insights into the genetics of complex diseases. By…”
Get full text

Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes by Miguel-Escalada, Irene, Bonàs-Guarch, Silvia, Cebola, Inês, Ponsa-Cobas, Joan, Mendieta-Esteban, Julen, Atla, Goutham, Javierre, Biola M., Rolando, Delphine M.Y., Farabella, Irene, Morgan, Claire C., García-Hurtado, Javier, Beucher, Anthony, Morán, Ignasi, Pasquali, Lorenzo, Ramos-Rodríguez, Mireia, Appel, Emil V.R., Linneberg, Allan, Gjesing, Anette P., Witte, Daniel R., Pedersen, Oluf, Grarup, Niels, Ravassard, Philippe, Torrents, David, Mercader, Josep M., Piemonti, Lorenzo, Berney, Thierry, de Koning, Eelco J.P., Kerr-Conte, Julie, Pattou, François, Fedko, Iryna O., Groop, Leif, Prokopenko, Inga, Hansen, Torben, Marti-Renom, Marc A., Fraser, Peter, Ferrer, Jorge

“…Genetic studies promise to provide insight into the molecular mechanisms underlying type 2 diabetes (T2D). Variants associated with T2D are often located in…”
Get full text