Search Results - "Morgan, Christopher E."

Structural and Functional Diversity of Resistance–Nodulation–Cell Division Transporters by Klenotic, Philip A, Moseng, Mitchell A, Morgan, Christopher E, Yu, Edward W

“…Multidrug resistant (MDR) bacteria are a global threat with many common infections becoming increasingly difficult to eliminate. While significant effort has…”
Get full text

A ‘Build and Retrieve’ methodology to simultaneously solve cryo-EM structures of membrane proteins by Su, Chih-Chia, Lyu, Meinan, Morgan, Christopher E., Bolla, Jani Reddy, Robinson, Carol V., Yu, Edward W.

“…Single-particle cryo-electron microscopy (cryo-EM) has become a powerful technique in the field of structural biology. However, the inability to reliably…”
Get full text

Structures of the mycobacterial membrane protein MmpL3 reveal its mechanism of lipid transport by Su, Chih-Chia, Klenotic, Philip A, Cui, Meng, Lyu, Meinan, Morgan, Christopher E, Yu, Edward W

“…The mycobacterial membrane protein large 3 (MmpL3) transporter is essential and required for shuttling the lipid trehalose monomycolate (TMM), a precursor of…”
Get full text

Cryo-EM Determination of Eravacycline-Bound Structures of the Ribosome and the Multidrug Efflux Pump AdeJ of Acinetobacter baumannii by Zhang, Zhemin, Morgan, Christopher E, Bonomo, Robert A, Yu, Edward W

“…Antibiotic-resistant strains of the Gram-negative pathogen Acinetobacter baumannii have emerged as a significant global health threat. One successful…”
Get full text

Rules of RNA specificity of hnRNP A1 revealed by global and quantitative analysis of its affinity distribution by Jain, Niyati, Lin, Hsuan-Chun, Morgan, Christopher E., Harris, Michael E., Tolbert, Blanton S.

“…Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a multipurpose RNA-binding protein (RBP) involved in normal and pathological RNA metabolism…”
Get full text

Cryo-EM Structures of the Klebsiella pneumoniae AcrB Multidrug Efflux Pump by Zhang, Zhemin, Morgan, Christopher E, Bonomo, Robert A, Yu, Edward W

“…The continued challenges of the COVID-19 pandemic combined with the growing problem of antimicrobial-resistant bacterial infections has severely impacted…”
Get full text

Cryo-EM Structures of AcrD Illuminate a Mechanism for Capturing Aminoglycosides from Its Central Cavity by Zhang, Zhemin, Morgan, Christopher E, Cui, Meng, Yu, Edward W

“…The Escherichia coli acriflavine resistance protein D (AcrD) is an efflux pump that belongs to the resistance-nodulation-cell division (RND) superfamily. Its…”
Get full text

Cryoelectron Microscopy Structures of AdeB Illuminate Mechanisms of Simultaneous Binding and Exporting of Substrates by Morgan, Christopher E, Glaza, Przemyslaw, Leus, Inga V, Trinh, Anhthu, Su, Chih-Chia, Cui, Meng, Zgurskaya, Helen I, Yu, Edward W

“…is a Gram-negative pathogen that has emerged as one of the most highly antibiotic-resistant bacteria worldwide. Multidrug efflux within these highly…”
Get full text

An Analysis of the Novel Fluorocycline TP-6076 Bound to Both the Ribosome and Multidrug Efflux Pump AdeJ from Acinetobacter baumannii by Morgan, Christopher E, Zhang, Zhemin, Bonomo, Robert A, Yu, Edward W

“…Antibiotic resistance among bacterial pathogens continues to pose a serious global health threat. Multidrug-resistant (MDR) strains of the Gram-negative…”
Get full text

Cryo-Electron Microscopy Structure of an Acinetobacter baumannii Multidrug Efflux Pump by Su, Chih-Chia, Morgan, Christopher E, Kambakam, Sekhar, Rajavel, Malligarjunan, Scott, Harry, Huang, Wei, Emerson, Corey C, Taylor, Derek J, Stewart, Phoebe L, Bonomo, Robert A, Yu, Edward W

“…Resistance-nodulation-cell division multidrug efflux pumps are membrane proteins that catalyze the export of drugs and toxic compounds out of bacterial cells…”
Get full text

Cryo-electron Microscopy Structure of the Acinetobacter baumannii 70S Ribosome and Implications for New Antibiotic Development by Morgan, Christopher E, Huang, Wei, Rudin, Susan D, Taylor, Derek J, Kirby, James E, Bonomo, Robert A, Yu, Edward W

“…Antimicrobial resistance is a major health threat as it limits treatment options for infection. At the forefront of this serious issue is , a Gram-negative…”
Get full text

Cryo-Electron Microscopy Structures of a Campylobacter Multidrug Efflux Pump Reveal a Novel Mechanism of Drug Recognition and Resistance by Zhang, Zhemin, Lizer, Nicholas, Wu, Zuowei, Morgan, Christopher E, Yan, Yuqi, Zhang, Qijing, Yu, Edward W

“…Campylobacter jejuni is a bacterium that is commonly present in the intestinal tracts of animals. It is also a major foodborne pathogen that causes…”
Get full text

Mapping Protein–Protein Interactions at Birth: Single-Particle Cryo-EM Analysis of a Ribosome–Nascent Globin Complex by Masse, Meranda M., Hutchinson, Rachel B., Morgan, Christopher E., Allaman, Heather J., Guan, Hongqing, Yu, Edward W., Cavagnero, Silvia

“…Interactions between ribosome-bound nascent chains (RNCs) and ribosomal components are critical to elucidate the mechanism of cotranslational protein folding…”
Get full text

Toward structural-omics of the bovine retinal pigment epithelium by Morgan, Christopher E., Zhang, Zhemin, Miyagi, Masaru, Golczak, Marcin, Yu, Edward W.

“…The use of an integrated systems biology approach to investigate tissues and organs has been thought to be impracticable in the field of structural biology,…”
Get full text

HnRNP A1 Alters the Structure of a Conserved Enterovirus IRES Domain to Stimulate Viral Translation by Tolbert, Michele, Morgan, Christopher E., Pollum, Marvin, Crespo-Hernández, Carlos E., Li, Mei-Ling, Brewer, Gary, Tolbert, Blanton S.

“…Enteroviruses use a type I Internal Ribosome Entry Site (IRES) structure to facilitate protein synthesis and promote genome replication. Type I IRES elements…”
Get full text

High-resolution structural proteomics of mitochondria using the ‘Build and Retrieve’ methodology by Zhang, Zhemin, Tringides, Marios L., Morgan, Christopher E., Miyagi, Masaru, Mears, Jason A., Hoppel, Charles L., Yu, Edward W.

“…The application of integrated systems biology to the field of structural biology is a promising new direction, although it is still in the infant stages of…”
Get full text

Discovery of Nonretinoid Inhibitors of CRBP1: Structural and Dynamic Insights for Ligand-Binding Mechanisms by Plau, Jacqueline, Morgan, Christopher E., Fedorov, Yuriy, Banerjee, Surajit, Adams, Drew J., Blaner, William S., Yu, Edward W., Golczak, Marcin

“…The dysregulation of retinoid metabolism has been linked to prevalent ocular diseases including age-related macular degeneration and Stargardt disease…”
Get full text

Solution Structure of the HIV-1 Intron Splicing Silencer and Its Interactions with the UP1 Domain of Heterogeneous Nuclear Ribonucleoprotein (hnRNP) A1 by Jain, Niyati, Morgan, Christopher E., Rife, Brittany D., Salemi, Marco, Tolbert, Blanton S.

“…Splicing patterns in human immunodeficiency virus type 1 (HIV-1) are maintained through cis regulatory elements that recruit antagonistic host RNA-binding…”
Get full text

Introducing Structure–Energy Concepts of RNA at the Undergraduate Level: Nearest Neighbor Thermodynamics and NMR Spectroscopy of a GAGA Tetraloop by Takor, Gaius, Morgan, Christopher E, Chiu, Liang-Yuan, Kendrick, Nashea, Clark, Emily, Jaiswal, Rohan, Tolbert, Blanton S

“…Two-dimensional nuclear magnetic resonance (2D NMR) techniques are regularly used for the determination of RNA structures. In an effort to introduce advanced…”
Get full text

The First Crystal Structure of the UP1 Domain of hnRNP A1 Bound to RNA Reveals a New Look for an Old RNA Binding Protein by Morgan, Christopher E, Meagher, Jennifer L, Levengood, Jeffrey D, Delproposto, James, Rollins, Carrie, Stuckey, Jeanne A, Tolbert, Blanton S

“…The heterogeneous nuclear ribonucleoprotein (hnRNP) A1 protein is a multifunctional RNA binding protein implicated in a wide range of biological functions…”
Get full text