Search Results - "Morgan, Bruce A"

Dermal papilla cell number specifies hair size, shape and cycling and its reduction causes follicular decline by Chi, Woo, Wu, Eleanor, Morgan, Bruce A

“…Although the hair shaft is derived from the progeny of keratinocyte stem cells in the follicular epithelium, the growth and differentiation of follicular…”
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Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant by Kamberov, Yana G., Wang, Sijia, Tan, Jingze, Gerbault, Pascale, Wark, Abigail, Tan, Longzhi, Yang, Yajun, Li, Shilin, Tang, Kun, Chen, Hua, Powell, Adam, Itan, Yuval, Fuller, Dorian, Lohmueller, Jason, Mao, Junhao, Schachar, Asa, Paymer, Madeline, Hostetter, Elizabeth, Byrne, Elizabeth, Burnett, Melissa, McMahon, Andrew P., Thomas, Mark G., Lieberman, Daniel E., Jin, Li, Tabin, Clifford J., Morgan, Bruce A., Sabeti, Pardis C.

“…An adaptive variant of the human Ectodysplasin receptor, EDARV370A, is one of the strongest candidates of recent positive selection from genome-wide scans. We…”
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Distinct Stem Cell Populations Regenerate the Follicle and Interfollicular Epidermis by Levy, Vered, Lindon, Catherine, Harfe, Brian D., Morgan, Bruce A.

“…The regeneration of the skin and its appendages is thought to occur by the regulated activation of a dedicated stem cell population. A population of cells in…”
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A genetic basis of variation in eccrine sweat gland and hair follicle density by Kamberov, Yana G., Karlsson, Elinor K., Kamberova, Gerda L., Lieberman, Daniel E., Sabeti, Pardis C., Morgan, Bruce A., Tabin, Clifford J.

“…Among the unique features of humans, one of the most salient is the ability to effectively cool the body during extreme prolonged activity through the…”
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The serine protease Corin is a novel modifier of the agouti pathway by Enshell-Seijffers, David, Lindon, Catherine, Morgan, Bruce A.

“…The hair follicle is a model system for studying epithelial-mesenchymal interactions during organogenesis. Although analysis of the epithelial contribution to…”
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The “Skinny” on Wnt Signaling in Stem Cells by Morgan, Bruce A.

“…Although previous reports suggested that canonical Wnt signaling has opposing effects on epidermal and hair follicle stem cells, two recent papers (Choi…”
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β-Catenin activity in the dermal papilla of the hair follicle regulates pigment-type switching by Enshell-Seijffers, David, Lindon, Catherine, Wu, Eleanor, Taketo, Makoto M., Morgan, Bruce A., Tabin, Clifford J.

“…The switch between black and yellow pigment is mediated by the interaction between Melanocortin receptor 1 (Mc1r) and its antagonist Agouti, but the genetic…”
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Transcriptional regulation of the Ikzf1 locus by Yoshida, Toshimi, Landhuis, Esther, Dose, Marei, Hazan, Idit, Zhang, Jiangwen, Naito, Taku, Jackson, Audrey F., Wu, Jeffrey, Perotti, Elizabeth A., Kaufmann, Christoph, Gounari, Fotini, Morgan, Bruce A., Georgopoulos, Katia

“…Ikaros is a critical regulator of lymphocyte development and homeostasis; thus, understanding its transcriptional regulation is important from both…”
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Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis by Gao, Jing, DeRouen, Mindy C, Chen, Chih-Hsin, Nguyen, Michael, Nguyen, Ngon T, Ido, Hiroyuki, Harada, Kenji, Sekiguchi, Kiyotoshi, Morgan, Bruce A, Miner, Jeffery H, Oro, Anthony E, Marinkovich, M Peter

“…Hair morphogenesis takes place through reciprocal epithelial and mesenchymal signaling; however, the mechanisms controlling signal exchange are poorly…”
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β-catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair by Enshell-Seijffers, David, Lindon, Catherine, Kashiwagi, Mariko, Morgan, Bruce A.

“…The activity of keratinocytes in the hair follicle is regulated by signals from a specialized mesenchymal niche, the dermal papilla (DP). Here, mice expressing…”
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A double-negative thymocyte-specific enhancer augments Notch1 signaling to direct early T cell progenitor expansion, lineage restriction and β-selection by Kashiwagi, Mariko, Figueroa, Daniela Salgado, Ay, Ferhat, Morgan, Bruce A., Georgopoulos, Katia

“…T cell differentiation requires Notch1 signaling. In the present study, we show that an enhancer upstream of Notch1 active in double-negative (DN) mouse…”
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The dermal papilla: an instructive niche for epithelial stem and progenitor cells in development and regeneration of the hair follicle by Morgan, Bruce A

“…The dermal papilla (DP) of the hair follicle is both a chemical and physical niche for epithelial progenitor cells that regenerate the cycling portion of the…”
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Functional interactions between Mi-2β and AP1 complexes control response and recovery from skin barrier disruption by Shibata, Sayaka, Kashiwagi, Mariko, Morgan, Bruce A, Georgopoulos, Katia

“…Keratinocytes respond to environmental signals by eliciting induction of genes that preserve skin's integrity. Here we show that the transcriptional response…”
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The ectodysplasin pathway in feather tract development by Houghton, Leslie, Lindon, Catherine, Morgan, Bruce A

“…The ectodysplasin pathway, comprising the ligand ectodysplasin, its receptor Edar and a dedicated death domain adaptor protein Edaradd, plays an important role…”
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Epidermal stem cells arise from the hair follicle after wounding by Levy, Vered, Lindon, Catherine, Zheng, Ying, Harfe, Brian D, Morgan, Bruce A

“…During normal development, the epidermis and hair follicle are distinct lineage compartments maintained by independent stem cell populations. Both epidermal…”
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Direct control of regulatory T cells by keratinocytes by Kashiwagi, Mariko, Hosoi, Junichi, Lai, Jen-Feng, Brissette, Janice, Ziegler, Steven F, Morgan, Bruce A, Georgopoulos, Katia

“…Skin is constantly exposed to environmental stressors. Georgopoulos and colleagues show that regulatory T cells respond to the cytokine TSLP produced by…”
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Lineage-specific 3D genome organization is assembled at multiple scales by IKAROS by Hu, Yeguang, Salgado Figueroa, Daniela, Zhang, Zhihong, Veselits, Margaret, Bhattacharyya, Sourya, Kashiwagi, Mariko, Clark, Marcus R., Morgan, Bruce A., Ay, Ferhat, Georgopoulos, Katia

“…A generic level of chromatin organization generated by the interplay between cohesin and CTCF suffices to limit promiscuous interactions between regulatory…”
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Eos Is Redundant for Regulatory T Cell Function but Plays an Important Role in IL-2 and Th17 Production by CD4+ Conventional T Cells by Rieder, Sadiye Amcaoglu, Metidji, Amina, Glass, Deborah Dacek, Thornton, Angela M, Ikeda, Tohru, Morgan, Bruce A, Shevach, Ethan M

“…Eos belongs to the Ikaros family of transcription factors. It was reported to be a regulatory T cell (Treg) signature gene, to play a critical role in Treg…”
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Stabilization of β-Catenin Does Not Increase Dermal Papilla Cell Number in the Hair Follicle by Chi, Woo, Morgan, Odysseas, Wu, Eleanor, Morgan, Bruce A.

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Comparative evidence for the independent evolution of hair and sweat gland traits in primates by Kamberov, Yana G., Guhan, Samantha M., DeMarchis, Alessandra, Jiang, Judy, Wright, Sara Sherwood, Morgan, Bruce A., Sabeti, Pardis C., Tabin, Clifford J., Lieberman, Daniel E.

“…Humans differ in many respects from other primates, but perhaps no derived human feature is more striking than our naked skin. Long purported to be adaptive,…”
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