Search Results - "Moretti, Paul A.B"

Translocation of Sphingosine Kinase 1 to the Plasma Membrane Is Mediated by Calcium- and Integrin-binding Protein 1 by Jarman, Kate E., Moretti, Paul A.B., Zebol, Julia R., Pitson, Stuart M.

“…SK1 (sphingosine kinase 1) plays an important role in many aspects of cellular regulation. Most notably, elevated cellular SK1 activity leads to increased cell…”
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Activation of sphingosine kinase 1 by ERK1/2-mediated phosphorylation by Pitson, Stuart M, Moretti, Paul A.B, Zebol, Julia R, Lynn, Helen E, Xia, Pu, Vadas, Mathew A, Wattenberg, Binks W

“…Sphingosine kinase 1 is an agonist‐activated signalling enzyme that catalyses the formation of sphingosine 1‐phosphate, a lipid second messenger that has been…”
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Deactivation of Sphingosine Kinase 1 by Protein Phosphatase 2A by Barr, Renae K., Lynn, Helen E., Moretti, Paul A.B., Khew-Goodall, Yeesim, Pitson, Stuart M.

“…Sphingosine kinase 1 (SK1) is an important regulator of cellular signaling that has been implicated in a broad range of cellular processes. Cell exposure to a…”
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Attenuation of leakiness in doxycycline-inducible expression via incorporation of 3' AU-rich mRNA destabilizing elements by Pham, Duyen H, Moretti, Paul A B, Goodall, Gregory J, Pitson, Stuart M

“…Tetracycline-regulated expression systems have been widely used for inducible protein expression in cultured mammalian cells. With these systems, however,…”
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A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties by Pitman, Melissa R, Powell, Jason A, Coolen, Carl, Moretti, Paul A B, Zebol, Julia R, Pham, Duyen H, Finnie, John W, Don, Anthony S, Ebert, Lisa M, Bonder, Claudine S, Gliddon, Briony L, Pitson, Stuart M

“…The dynamic balance of cellular sphingolipids, the sphingolipid rheostat, is an important determinant of cell fate, and is commonly deregulated in cancer…”
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A critical role for the protein phosphatase 2A B′α regulatory subunit in dephosphorylation of sphingosine kinase 1 by Pitman, Melissa R., Barr, Renae K., Gliddon, Briony L., Magarey, Angus M., Moretti, Paul A.B., Pitson, Stuart M.

“…Sphingosine kinase 1 (SK1) is an important regulator of cellular signalling that has gained recent attention as a potential target for anti-cancer therapies…”
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The Calmodulin-binding Site of Sphingosine Kinase and Its Role in Agonist-dependent Translocation of Sphingosine Kinase 1 to the Plasma Membrane by Sutherland, Catherine M., Moretti, Paul A.B., Hewitt, Niamh M., Bagley, Christopher J., Vadas, Mathew A., Pitson, Stuart M.

“…Sphingosine kinases catalyze the formation of sphingosine 1-phosphate, a bioactive lipid involved in many aspects of cellular regulation, including the…”
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Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes by Pitson, S M, D'andrea, R J, Vandeleur, L, Moretti, P A, Xia, P, Gamble, J R, Vadas, M A, Wattenberg, B W

“…Sphingosine 1-phosphate (S1P) is a novel lipid messenger that has important roles in a wide variety of mammalian cellular processes including growth,…”
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Molecular Cloning of a Human Vent-like Homeobox Gene by Moretti, Paul A.B, Davidson, Alan J, Baker, Elizabeth, Lilley, Brendan, Zon, Leonard I, D'Andrea, Richard J

“…We have isolated a previously unknown human homeobox-containing cDNA, VENT-like homeobox-2 (VENTX2), using PCR with a bone marrow cDNA library and primers…”
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Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia by Lewis, Alexander C., Pope, Victoria S., Tea, Melinda N., Li, Manjun, Nwosu, Gus O., Nguyen, Thao M., Wallington-Beddoe, Craig T., Moretti, Paul A.B., Anderson, Dovile, Creek, Darren J., Costabile, Maurizio, Ali, Saira R., Thompson-Peach, Chloe A.L., Dredge, B. Kate, Bert, Andrew G., Goodall, Gregory J., Ekert, Paul G., Brown, Anna L., D'Andrea, Richard, Robinson, Nirmal, Pitman, Melissa R., Thomas, Daniel, Ross, David M., Gliddon, Briony L., Powell, Jason A., Pitson, Stuart M.

“…Inducing cell death by the sphingolipid ceramide is a potential anti-cancer strategy, but the underlying mechanisms remain poorly defined. Here, we show that…”
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Targeting human CALR‐mutated MPN progenitors with a neoepitope‐directed monoclonal antibody by Tvorogov, Denis, Thompson‐Peach, Chloe A L, Foßelteder, Johannes, Dottore, Mara, Stomski, Frank, Onnesha, Suraiya A, Lim, Kelly, Moretti, Paul A B, Pitson, Stuart M, Ross, David M, Reinisch, Andreas, Thomas, Daniel, Lopez, Angel F

“…Calreticulin (CALR) is recurrently mutated in myelofibrosis via a frameshift that removes an endoplasmic reticulum retention signal, creating a neoepitope…”
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Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia by Powell, Jason A., Lewis, Alexander C., Zhu, Wenying, Toubia, John, Pitman, Melissa R., Wallington-Beddoe, Craig T., Moretti, Paul A.B., Iarossi, Diana, Samaraweera, Saumya E., Cummings, Nik, Ramshaw, Hayley S., Thomas, Daniel, Wei, Andrew H., Lopez, Angel F., D'Andrea, Richard J., Lewis, Ian D., Pitson, Stuart M.

“…Acute myeloid leukemia (AML) is an aggressive malignancy where despite improvements in conventional chemotherapy and bone marrow transplantation, overall…”
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The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism by Pitman, Melissa R., Lewis, Alexander C., Davies, Lorena T., Moretti, Paul A. B., Anderson, Dovile, Creek, Darren J., Powell, Jason A., Pitson, Stuart M.

“…Sphingosine 1-phosphate (S1P) is a signaling lipid that has broad roles, working either intracellularly through various protein targets, or extracellularly via…”
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CIB2 Negatively Regulates Oncogenic Signaling in Ovarian Cancer via Sphingosine Kinase 1 by Zhu, Wenying, Jarman, Kate E, Lokman, Noor A, Neubauer, Heidi A, Davies, Lorena T, Gliddon, Briony L, Taing, Houng, Moretti, Paul A B, Oehler, Martin K, Pitman, Melissa R, Pitson, Stuart M

“…Sphingosine kinase 1 (SK1) is a key regulator of the cellular balance between proapoptotic and prosurvival sphingolipids. Oncogenic signaling by SK1 relies on…”
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Sphingosine kinase 2 inhibition synergises with bortezomib to target myeloma by enhancing endoplasmic reticulum stress by Wallington-Beddoe, Craig T, Bennett, Melissa K, Vandyke, Kate, Davies, Lorena, Zebol, Julia R, Moretti, Paul A B, Pitman, Melissa R, Hewett, Duncan R, Zannettino, Andrew C W, Pitson, Stuart M

“…The proteasome inhibitor bortezomib has proven to be invaluable in the treatment of myeloma. By exploiting the inherent high immunoglobulin protein production…”
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Cytoplasmic dynein regulates the subcellular localization of sphingosine kinase 2 to elicit tumor-suppressive functions in glioblastoma by Neubauer, Heidi A., Tea, Melinda N., Zebol, Julia R., Gliddon, Briony L., Stefanidis, Cassandra, Moretti, Paul A. B., Pitman, Melissa R., Costabile, Maurizio, Kular, Jasreen, Stringer, Brett W., Day, Bryan W., Samuel, Michael S., Bonder, Claudine S., Powell, Jason A., Pitson, Stuart M.

“…While the two mammalian sphingosine kinases, SK1 and SK2, both catalyze the generation of pro-survival sphingosine 1-phosphate (S1P), their roles vary…”
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An oncogenic role for sphingosine kinase 2 by Neubauer, Heidi A, Pham, Duyen H, Zebol, Julia R, Moretti, Paul A B, Peterson, Amanda L, Leclercq, Tamara M, Chan, Huasheng, Powell, Jason A, Pitman, Melissa R, Samuel, Michael S, Bonder, Claudine S, Creek, Darren J, Gliddon, Briony L, Pitson, Stuart M

“…While both human sphingosine kinases (SK1 and SK2) catalyze the generation of the pleiotropic signaling lipid sphingosine 1-phosphate, these enzymes appear to…”
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Expression of a Catalytically Inactive Sphingosine Kinase Mutant Blocks Agonist-induced Sphingosine Kinase Activation by Pitson, Stuart M., Moretti, Paul A.B., Zebol, Julia R., Xia, Pu, Gamble, Jennifer R., Vadas, Mathew A., D'Andrea, Richard J., Wattenberg, Binks W.

“…Sphingosine kinase (SK) catalyzes the formation of sphingosine 1-phosphate (S1P), a lipid messenger that plays an important role in a variety of mammalian cell…”
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Phosphorylation-dependent translocation of sphingosine kinase to the plasma membrane drives its oncogenic signalling by Pitson, Stuart M, Xia, Pu, Leclercq, Tamara M, Moretti, Paul A B, Zebol, Julia R, Lynn, Helen E, Wattenberg, Binks W, Vadas, Mathew A

“…Sphingosine kinase (SK) 1 catalyzes the formation of the bioactive lipid sphingosine 1-phosphate, and has been implicated in several biological processes in…”
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An oncogenic role of sphingosine kinase by Xia, Pu, Gamble, Jennifer R., Wang, Lijun, Pitson, Stuart M., Moretti, Paul A.B., Wattenberg, Binks W., D'Andrea, Richard J., Vadas, Mathew A.

“…Sphingosine kinase (SphK) is a highly conserved lipid kinase that phosphorylates sphingosine to form sphingosine-1-phosphate (S1P). S1P/SphK has been…”
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