Search Results - "Morera, Ludovica"

Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds by Ortar, Giorgio, Morera, Ludovica, Schiano Moriello, Aniello, Morera, Enrico, Nalli, Marianna, Di Marzo, Vincenzo, De Petrocellis, Luciano

“…A series of thirty-three thymol, p-cymene-3-carboxylic acid, and 3-amino-p-cymene derivatives was synthesized and tested on TRPA1, TRPM8, and TRPV3 channels…”
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Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy by Morera, Ludovica, Lübbert, Michael, Jung, Manfred

“…The term epigenetics is defined as heritable changes in gene expression that are not due to alterations of the DNA sequence. In the last years, it has become…”
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Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators by Morera, Enrico, De Petrocellis, Luciano, Morera, Ludovica, Schiano Moriello, Aniello, Nalli, Marianna, Di Marzo, Vincenzo, Ortar, Giorgio

“…In order to explore the structural determinants for the TRPV1 and TRPA1 agonist properties of gingerols, a series of nineteen analogues (1b–5) of racemic…”
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Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid CB 1 Receptor by Piscitelli, Francesco, Ligresti, Alessia, La Regina, Giuseppe, Coluccia, Antonio, Morera, Ludovica, Allarà, Marco, Novellino, Ettore, Di Marzo, Vincenzo, Silvestri, Romano

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Indole-2-carboxamides as Allosteric Modulators of the Cannabinoid CB1 Receptor by Piscitelli, Francesco, Ligresti, Alessia, La Regina, Giuseppe, Coluccia, Antonio, Morera, Ludovica, Allarà, Marco, Novellino, Ettore, Di Marzo, Vincenzo, Silvestri, Romano

“…We synthesized new N-phenylethyl-1H-indole-2-carboxamides as the first SAR study of allosteric modulators of the CB1 receptor. The presence of the carboxamide…”
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Development and characterization of endocannabinoid hydrolases FAAH and MAGL inhibitors bearing a benzotriazol-1-yl carboxamide scaffold by Morera, Ludovica, Labar, Geoffray, Ortar, Giorgio, Lambert, Didier M.

“…A series of (1H-benzo[d][1,2,3]triazol-1-yl)(4-benzylpiperazin-1-yl)methanones and of (1H-benzo[d][1,2,3]triazol-1-yl)(4-phenylpiperazin-1-yl)methanones has…”
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Biaryl tetrazolyl ureas as inhibitors of endocannabinoid metabolism: Modulation at the N-portion and distal phenyl ring by Ortar, Giorgio, Morera, Enrico, De Petrocellis, Luciano, Ligresti, Alessia, Schiano Moriello, Aniello, Morera, Ludovica, Nalli, Marianna, Ragno, Rino, Pirolli, Adele, Di Marzo, Vincenzo

“…In the present study, we have further extended the structure–activity relationships for the tetrazolyl ureas class of compounds as potential FAAH and/or MAGL…”
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(−)-Menthylamine derivatives as potent and selective antagonists of transient receptor potential melastatin type-8 (TRPM8) channels by Ortar, Giorgio, Petrocellis, Luciano De, Morera, Ludovica, Moriello, Aniello Schiano, Orlando, Pierangelo, Morera, Enrico, Nalli, Marianna, Marzo, Vincenzo Di

“…The evaluation of a series of (−)-menthylamine derivatives led to the identification of some potent TRPM8 antagonists with IC 50 values versus icilin and…”
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4-Biphenylalanine- and 3-Phenyltyrosine-Derived Hydroxamic Acids as Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A by Morera, Ludovica, Roatsch, Martin, Fürst, Michael C. D., Hoffmann, Inga, Senger, Johanna, Hau, Mirjam, Franz, Henriette, Schüle, Roland, Heinrich, Markus R., Jung, Manfred

“…Overexpression of the histone lysine demethylase KDM4A, which regulates H3K9 and H3K36 methylation states, has been related to the pathology of several human…”
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2-(Alkyl/Aryl)Amino-6-Benzylpyrimidin-4(3H)-ones as Inhibitors of Wild-Type and Mutant HIV-1: Enantioselectivity Studies by Rotili, Dante, Samuele, Alberta, Tarantino, Domenico, Ragno, Rino, Musmuca, Ira, Ballante, Flavio, Botta, Giorgia, Morera, Ludovica, Pierini, Marco, Cirilli, Roberto, Nawrozkij, Maxim B, Gonzalez, Emmanuel, Clotet, Bonaventura, Artico, Marino, Esté, José A, Maga, Giovanni, Mai, Antonello

“…The single enantiomers of two pyrimidine-based HIV-1 non-nucleoside reverse transcriptase inhibitors, 1 (MC1501) and 2 (MC2082), were tested in both cellular…”
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Synthesis and biological evaluation of piperazinyl carbamates and ureas as fatty acid amide hydrolase (FAAH) and transient receptor potential (TRP) channel dual ligands by Morera, Enrico, De Petrocellis, Luciano, Morera, Ludovica, Moriello, Aniello Schiano, Ligresti, Alessia, Nalli, Marianna, Woodward, David F., Di Marzo, Vincenzo, Ortar, Giorgio

“…The evaluation of a series of piperazinyl carbamates and ureas, designed on the basis of previously reported TRPV1 antagonists and FAAH inhibitors, led to the…”
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