Search Results - "Moreno Valladares, Manuel"
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CD8+ T cells are increased in the subventricular zone with physiological and pathological aging
Published in Aging cell (01-09-2020)“…Age‐related cognitive decline and neurodegenerative diseases are associated with less functional neurogenic niches. It has been recently shown that aged…”
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Neuronal p38α mediates age‐associated neural stem cell exhaustion and cognitive decline
Published in Aging cell (01-12-2019)“…Neuronal activity regulates cognition and neural stem cell (NSC) function. The molecular pathways limiting neuronal activity during aging remain largely…”
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High SOX9 Maintains Glioma Stem Cell Activity through a Regulatory Loop Involving STAT3 and PML
Published in International journal of molecular sciences (19-04-2022)“…Glioma stem cells (GSCs) are critical targets for glioma therapy. SOX9 is a transcription factor with critical roles during neurodevelopment, particularly…”
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Expression of cellular senescence and neural stem cell markers in a case of advanced retinal fibrosis
Published in Aging medicine (01-12-2019)“…The progressive accumulation of cell damage over time promotes the induction of senescence in which cells block their capacity to divide and acquire functions…”
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Centenarian hippocampus displays high levels of astrocytic metallothioneins
Published in Aging cell (01-08-2024)“…The hippocampus is a brain area linked to cognition. The mechanisms that maintain cognitive activity in humans are poorly understood. Centenarians display…”
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Norovirus Intestinal Infection and Lewy Body Disease in an Older Patient with Acute Cognitive Impairment
Published in International journal of molecular sciences (01-08-2022)“…We present a case report on an older woman with unspecific symptoms and predominant long-term gastrointestinal disturbances, acute overall health deterioration…”
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SOX9 promotes tumor progression through the axis BMI1-p21CIP
Published in Scientific reports (15-01-2020)“…The developmental regulator SOX9 is linked to cancer progression mainly as a result of its role in the regulation of cancer stem cells (CSCs). However, its…”
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Ki-67 immunoexpression and radiological assessment of necrosis improves accuracy of conventional and modified core biopsy systems in predicting the final grade assigned to adult-soft tissue sarcomas. An international collaborative study
Published in Pathology, research and practice (01-09-2021)“…Based on the French Federation Nationale des Centers de Lutte Contre le Cancer (FNCLCC) grading system, this study assesses the accuracy of conventional and…”
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KRT[5.sup.+]/p[63.sup.+] Stem Cells Undergo Senescence in the Human Lung with Pathological Aging
Published in Aging and disease (01-06-2023)“…Adult lungs present high cellular plasticity against stress and injury, mobilizing stem/progenitor populations from conducting airways to maintain tissue…”
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Identification of a novel gene signature related to prognosis and metastasis in gastric cancer
Published in Cellular oncology (Dordrecht) (01-08-2024)“…Background Gastric Cancer (GC) presents poor outcome, which is consequence of the high incidence of recurrence and metastasis at early stages. GC patients…”
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Frailty is associated with mortality in brain tumor patients
Published in American journal of cancer research (01-01-2021)“…Frailty represents a state of vulnerability that increases the risk of adverse health outcomes. In the last years, frailty has emerged as a good indicator of…”
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CD8 + T cells are present at low levels in the white matter with physiological and pathological aging
Published in Aging (Albany, NY.) (13-10-2020)“…The presence and functional role of T cell infiltration in human brain parenchyma with normal aging and neurodegeneration is still under intense debate…”
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KRT5 + /p63 + Stem Cells Undergo Senescence in the Human Lung with Pathological Aging
Published in Aging and disease (01-06-2023)“…Adult lungs present high cellular plasticity against stress and injury, mobilizing stem/progenitor populations from conducting airways to maintain tissue…”
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Müllerian adenosarcoma with sarcomatous overgrowth and heterologous elements: A case report and literature review
Published in Revista española de patología (01-07-2024)“…Uterine mullerian adenosarcoma (MA) is a rare biphasic tumour that accounts for less than 0.5% of uterine neoplasms. The age range of presentation is wide,…”
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The Pseudokinase TRIB3 Negatively Regulates the HER2 Receptor Pathway and Is a Biomarker of Good Prognosis in Luminal Breast Cancer
Published in Cancers (22-10-2021)“…Background: Tribbles pseudokinase 3 (TRIB3) has been proposed to both promote and restrict cancer generation and progression. However, the precise mechanisms…”
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Internal Carotid Artery Web as the Cause of Recurrent Cryptogenic Ischemic Stroke
Published in Journal of stroke and cerebrovascular diseases (01-05-2018)“…Carotid artery web is considered an exceptional cause of recurrent ischemic strokes in the affected arterial territory. The underlying pathology proposed for…”
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SOX9 promotes tumor progression through the axis BMI1-p21 CIP
Published in Scientific reports (15-01-2020)“…The developmental regulator SOX9 is linked to cancer progression mainly as a result of its role in the regulation of cancer stem cells (CSCs). However, its…”
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A new percutaneous model of Subarachnoid Haemorrhage in rats
Published in Journal of neuroscience methods (15-10-2012)“…► We described a new rat model of SAH by percutaneous injection of autologous, non-heparinised blood into the intracisternal space. ► The model is…”
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