Search Results - "Moreno Garcia, E"

Arginine: Its pKa value revisited by Fitch, Carolyn A, Platzer, Gerald, Okon, Mark, Garcia-Moreno, Bertrand E, McIntosh, Lawrence P

“…Using complementary approaches of potentiometry and NMR spectroscopy, we have determined that the equilibrium acid dissociation constant (pKa value) of the…”
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The pKa Cooperative: A collaborative effort to advance structure-based calculations of pKa values and electrostatic effects in proteins by Nielsen, Jens E., Gunner, M. R., García-Moreno E., Bertrand

“…The pKa Cooperative (http://www.pkacoop.org) was organized to advance development of accurate and useful computational methods for structure‐based calculation…”
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Protein Dielectric Constants Determined from NMR Chemical Shift Perturbations by Kukic, Predrag, Farrell, Damien, McIntosh, Lawrence P, García-Moreno E, Bertrand, Jensen, Kristine Steen, Toleikis, Zigmantas, Teilum, Kaare, Nielsen, Jens Erik

“…Understanding the connection between protein structure and function requires a quantitative understanding of electrostatic effects. Structure-based…”
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Structural and thermodynamic consequences of burial of an artificial ion pair in the hydrophobic interior of a protein by Robinson, Aaron C., Castañeda, Carlos A., Schlessman, Jamie L., García-Moreno E., Bertrand

“…An artificial charge pair buried in the hydrophobic core of staphyiococcal nuclease was engineered by making the V23E and L36K substitutions. Buried…”
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Structural, energetic, and dynamic responses of the native state ensemble of staphylococcal nuclease to cavity-creating mutations by Roche, Julien, Caro, Jose A., Dellarole, Mariano, Guca, Ewelina, Royer, Catherine A., García-Moreno E., Bertrand, Garcia, Angel E., Roumestand, Christian

“…The effects of cavity‐creating mutations on the structural flexibility, local and global stability, and dynamics of the folded state of staphylococcal nuclease…”
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Local Conformational Fluctuations Can Modulate the Coupling between Proton Binding and Global Structural Transitions in Proteins by Whitten, Steven T., Bertrand García-Moreno E., Hilser, Vincent J., DeGrado, William F.

“…Local conformational fluctuations in proteins can affect the coupling between ligand binding and global structural transitions. This finding was established by…”
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Conformational Consequences of Ionization of Lys, Asp, and Glu Buried at Position 66 in Staphylococcal Nuclease by Karp, Daniel A, Stahley, Mary R, García-Moreno E, Bertrand

“…The pK a values measured previously for the internal Lys-66, Asp-66, and Glu-66 in variants of a highly stable form of staphylococcal nuclease are shifted by…”
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A Statistical Thermodynamic Model of the Protein Ensemble by Hilser, Vincent J, García-Moreno E, Bertrand, Oas, Terrence G, Kapp, Greg, Whitten, Steven T

“…The background, physical basis, and the experimental validation of a structural thermodynamic model of the protein ensemble known as COREX is reviewed. The…”
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High Apparent Dielectric Constant Inside a Protein Reflects Structural Reorganization Coupled to the Ionization of an Internal Asp by Karp, Daniel A., Gittis, Apostolos G., Stahley, Mary R., Fitch, Carolyn A., Stites, Wesley E., García-Moreno E., Bertrand

“…The dielectric properties of proteins are poorly understood and difficult to describe quantitatively. This limits the accuracy of methods for structure-based…”
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Induction of Apoptosis in Colon Cancer Cells Treated with Isorhamnetin Glycosides from Opuntia Ficus-indica Pads by Antunes-Ricardo, Marilena, Moreno-García, Beatriz E, Gutiérrez-Uribe, Janet A, Aráiz-Hernández, Diana, Alvarez, Mario M, Serna-Saldivar, Sergio O

“…(OFI) contains health-promoting compounds like flavonoids, being the isorhamnetin glycosides the most abundant. We evaluated the effect of OFI extracts with…”
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Probing the Physical Determinants of Thermal Expansion of Folded Proteins by Dellarole, Mariano, Kobayashi, Kei, Rouget, Jean-Baptiste, Caro, José Alfredo, Roche, Julien, Islam, Mohammad M, Garcia-Moreno E, Bertrand, Kuroda, Yutaka, Royer, Catherine A

“…The magnitude and sign of the volume change upon protein unfolding are strongly dependent on temperature. This temperature dependence reflects differences in…”
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Structural plasticity of staphylococcal nuclease probed by perturbation with pressure and pH by Kitahara, Ryo, Hata, Kazumi, Maeno, Akihiro, Akasaka, Kazuyuki, Chimenti, Michael S., Garcia-Moreno E., Bertrand, Schroer, Martin A., Jeworrek, Christoph, Tolan, Metin, Winter, Roland, Roche, Julien, Roumestand, Christian, Montet de Guillen, Karine, Royer, Catherine A.

“…The ionization of internal groups in proteins can trigger conformational change. Despite this being the structural basis of most biological energy…”
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The role of hydrophobic microenvironments in modulating pKa shifts in proteins by Mehler, E.L., Fuxreiter, M., Simon, I., Garcia-Moreno E, B.

“…The screened Coulomb potential (SCP) method, combined with a quantitative description of the microenvironments around titratable groups, based on the…”
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Kinase-Independent Feedback of the TAK1/TAB1 Complex on BCL10 Turnover and NF-κB Activation by Moreno-García, Miguel E., Sommer, Karen, Rincon-Arano, Hector, Brault, Michelle, Ninomiya-Tsuji, Jun, Matesic, Lydia E., Rawlings, David J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Chemotaxis and Calcium Responses of Phagocytes to Formyl Peptide Receptor Ligands Is Differentially Regulated by Cyclic ADP Ribose by Partida-Sanchez, Santiago, Iribarren, Pablo, Moreno-Garcia, Miguel E, Gao, Ji-Liang, Murphy, Philip M, Oppenheimer, Norman, Wang, Ji Ming, Lund, Frances E

“…Cyclic ADP ribose (cADPR) is a calcium-mobilizing metabolite that regulates intracellular calcium release and extracellular calcium influx. Although the role…”
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Cavities determine the pressure unfolding of proteins by Roche, Julien, Caro, Jose A, Norberto, Douglas R, Barthe, Philippe, Roumestand, Christian, Schlessman, Jamie L, Garcia, Angel E, García-Moreno E., Bertrand, Royer, Catherine A

“…It has been known for nearly 100 years that pressure unfolds proteins, yet the physical basis of this effect is not understood. Unfolding by pressure implies…”
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Electrostatic Effects in a Network of Polar and Ionizable Groups in Staphylococcal Nuclease by Baran, Kelli L., Chimenti, Michael S., Schlessman, Jamie L., Fitch, Carolyn A., Herbst, Katie J., Garcia-Moreno, Bertrand E.

“…His121 and His124 are embedded in a network of polar and ionizable groups on the surface of staphylococcal nuclease. To examine how membership in a network…”
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Crystallographic Study of Hydration of an Internal Cavity in Engineered Proteins with Buried Polar or Ionizable Groups by Schlessman, Jamie L., Abe, Colby, Gittis, Apostolos, Karp, Daniel A., Dolan, Michael A., García-Moreno E., Bertrand

“…Although internal water molecules are essential for the structure and function of many proteins, the structural and physical factors that govern internal…”
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CD38 induces differentiation of immature transitional 2 B lymphocytes in the spleen by Rodríguez-Alba, Juan C., Moreno-García, Miguel E., Sandoval-Montes, Claudia, Rosales-Garcia, Víctor H., Santos-Argumedo, Leopoldo

“…CD38 is a surface receptor able to induce activation, proliferation, and survival of human and mouse lymphocytes; this molecule is expressed on the surface of…”
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Arginine residues at internal positions in a protein are always charged by Harms, Michael J, Schlessman, Jamie L, Sue, Gloria R, García-Moreno E., Bertrand

“…Many functionally essential ionizable groups are buried in the hydrophobic interior of proteins. A systematic study of Lys, Asp, and Glu residues at 25…”
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