Search Results - "Moreno‐López, Bernardo"

Reduction in the Motoneuron Inhibitory/Excitatory Synaptic Ratio in an Early-Symptomatic Mouse Model of Amyotrophic Lateral Sclerosis by Sunico, Carmen R., Domínguez, Germán, García-Verdugo, José Manuel, Osta, Rosario, Montero, Fernando, Moreno-López, Bernardo

“…Excitotoxicity is a widely studied mechanism underlying motoneuron degeneration in amyotrophic lateral sclerosis (ALS). Synaptic alterations that produce an…”
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Local isoform-specific NOS inhibition: A promising approach to promote motor function recovery after nerve injury by Moreno-López, Bernardo

“…Physical injury to a nerve is the most frequent cause of acquired peripheral neuropathy, which is responsible for loss of motor, sensory and/or autonomic…”
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Endogenous Rho-kinase signaling maintains synaptic strength by stabilizing the size of the readily releasable pool of synaptic vesicles by González-Forero, David, Montero, Fernando, García-Morales, Victoria, Domínguez, Germán, Gómez-Pérez, Laura, García-Verdugo, José Manuel, Moreno-López, Bernardo

“…Rho-associated kinase (ROCK) regulates neural cell migration, proliferation and survival, dendritic spine morphology, and axon guidance and regeneration. There…”
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Lysophosphatidic Acid and Several Neurotransmitters Converge on Rho-Kinase 2 Signaling to Manage Motoneuron Excitability by García-Morales, Victoria, Gento-Caro, Ángela, Portillo, Federico, Montero, Fernando, González-Forero, David, Moreno-López, Bernardo

“…Intrinsic membrane excitability (IME) sets up neuronal responsiveness to synaptic drive. Several neurotransmitters and neuromodulators, acting through…”
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Age-dependent effect of nitric oxide on subventricular zone and olfactory bulb neural precursor proliferation by Romero-Grimaldi, Carmen, Moreno-López, Bernardo, Estrada, Carmen

“…Nitric oxide (NO) synthase (NOS) is developmentally regulated in the embryonic brain, where NO participates in cell proliferation, survival, and…”
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Nitric oxide controls excitatory/inhibitory balance in the hypoglossal nucleus during early postnatal development by Portillo, Federico, Moreno-López, Bernardo

“…Synaptic remodeling during early postnatal development lies behind neuronal networks refinement and nervous system maturation. In particular, the respiratory…”
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The nitric oxide/cyclic guanosine monophosphate pathway modulates the inspiratory-related activity of hypoglossal motoneurons in the adult rat by Montero, Fernando, Portillo, Federico, González-Forero, David, Moreno-López, Bernardo

“…Motoneurons integrate interneuronal activity into commands for skeletal muscle contraction and relaxation to perform motor actions. Hypoglossal motoneurons…”
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Targeting autotaxin impacts disease advance in the SOD1‐G93A mouse model of amyotrophic lateral sclerosis by Gento‐Caro, Ángela, Vilches‐Herrando, Esther, Portillo, Federico, González‐Forero, David, Moreno‐López, Bernardo

“…A preclinical strategy to broaden the search of potentially effective treatments in amyotrophic lateral sclerosis (ALS) relies on identifying factors…”
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Cannabinoid agonists rearrange synaptic vesicles at excitatory synapses and depress motoneuron activity in vivo by García-Morales, Victoria, Montero, Fernando, Moreno-López, Bernardo

“…Impairment of motor skills is one of the most common acute adverse effects of cannabis. Related studies have focused mainly on psychomotor alterations, and…”
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Interfering with lysophosphatidic acid receptor edg2/lpa 1 signalling slows down disease progression in SOD1-G93A transgenic mice by Gento-Caro, Ángela, Vilches-Herrando, Esther, García-Morales, Victoria, Portillo, Federico, Rodríguez-Bey, Guillermo, González-Forero, David, Moreno-López, Bernardo

“…Alterations in excitability represent an early hallmark in Amyotrophic Lateral Sclerosis (ALS). Therefore, deciphering the factors that impact motor neuron…”
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Interfering with lysophosphatidic acid receptor edg2/lpa1 signalling slows down disease progression in SOD1‐G93A transgenic mice by Gento‐Caro, Ángela, Vilches‐Herrando, Esther, García‐Morales, Victoria, Portillo, Federico, Rodríguez‐Bey, Guillermo, González‐Forero, David, Moreno‐López, Bernardo

“…Aims Alterations in excitability represent an early hallmark in Amyotrophic Lateral Sclerosis (ALS). Therefore, deciphering the factors that impact motor…”
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Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1 by García-Morales, Victoria, Rodríguez-Bey, Guillermo, Gómez-Pérez, Laura, Domínguez-Vías, Germán, González-Forero, David, Portillo, Federico, Campos-Caro, Antonio, Gento-Caro, Ángela, Issaoui, Noura, Soler, Rosa M., Garcera, Ana, Moreno-López, Bernardo

“…Disruption in membrane excitability contributes to malfunction and differential vulnerability of specific neuronal subpopulations in a number of neurological…”
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Membrane-derived phospholipids control synaptic neurotransmission and plasticity by García-Morales, Victoria, Montero, Fernando, González-Forero, David, Rodríguez-Bey, Guillermo, Gómez-Pérez, Laura, Medialdea-Wandossell, María Jesús, Domínguez-Vías, Germán, García-Verdugo, José Manuel, Moreno-López, Bernardo

“…Synaptic communication is a dynamic process that is key to the regulation of neuronal excitability and information processing in the brain. To date, however,…”
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ORAL ADMINISTRATION OF A LPA1/EDG2 INHIBITOR POTENTIATES HIGH-FAT DIET-INDUCED NEUROPROTECTION OF LUMBAR MOTONEURONS IN THE SOD1-G93A MOUSE MODEL OF ALS by Sánchez-García, Enrique, Vilches-Herrando, Esther, González-Forero, David, Moreno-López, Bernardo, Gento-Caro, Angela

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EFFECTS OF CHRONIC ADMINISTRATION OF THE AUTOTAXIN INHIBITOR PF8380 ON HIGH-FAT DIET-INDUCED BENEFICIAL EFFECTS ON A MOUSE MODEL OF ALS by Gento-Caro, Angela, Sánchez-García, Enrique, Vilches-Herrando, Esther, Ariza-Molina, Jorge, Moreno-López, Bernardo, González-Forero, David

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SIRNA-INDUCED DOWN-REGULATION OF P11/S100A10 IMPACTS STRENGTH AND USE-DEPENDENT PLASTICITY AT EXCITATORY SYNAPSES IN THE HYPOGLOSSAL NUCLEUS OF THE RAT by Vilches-Herrando, Esther, Gento-Caro, Angela, Sánchez-García, Enrique, González-Forero, David, Moreno-López, Bernardo

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Nitric oxide is a physiological inhibitor of neurogenesis in the adult mouse subventricular zone and olfactory bulb by Moreno-López, Bernardo, Romero-Grimaldi, Carmen, Noval, José Angel, Murillo-Carretero, Maribel, Matarredona, Esperanza R, Estrada, Carmen

“…The subventricular zone of the rodent brain retains the capacity of generating new neurons in adulthood. The newly formed neuroblasts migrate rostrally toward…”
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NO Orchestrates the Loss of Synaptic Boutons from Adult “Sick” Motoneurons: Modeling a Molecular Mechanism by Moreno-López, Bernardo, Sunico, Carmen R, González-Forero, David

“…Synapse elimination is the main factor responsible for the cognitive decline accompanying many of the neuropathological conditions affecting humans. Synaptic…”
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Nitric Oxide Induces Pathological Synapse Loss by a Protein Kinase G-, Rho Kinase-Dependent Mechanism Preceded by Myosin Light Chain Phosphorylation by Sunico, Carmen R, Gonzalez-Forero, David, Dominguez, German, Garcia-Verdugo, Jose Manuel, Moreno-Lopez, Bernardo

“…The molecular signaling that underpins synapse loss in neuropathological conditions remains unknown. Concomitant upregulation of the neuronal nitric oxide (NO)…”
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Evidence for endothelial nitric oxide as a negative regulator of Schwann cell dedifferentiation after peripheral nerve injury by Sunico, Carmen R., Moreno-López, Bernardo

“…The loss of intimate contact with axons triggers Schwann cells (SCs) to switch from a myelin-producing phenotype to a dedifferentiated, proliferating…”
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