Search Results - "Moreno, Pedro M. D"

Nuclease resistant oligonucleotides with cell penetrating properties by Milton, Stefan, Honcharenko, Dmytro, Rocha, Cristina S J, Moreno, Pedro M D, Smith, C I Edvard, Strömberg, Roger

“…2'-O-AECM modified oligonucleotides provide an unusual combination of remarkable properties. This includes the combination of high resistance towards enzymatic…”
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Therapeutic antisense oligonucleotides against cancer: hurdling to the clinic by Moreno, Pedro M D, Pêgo, Ana P

“…Under clinical development since the early 90's and with two successfully approved drugs (Fomivirsen and Mipomersen), oligonucleotide-based therapeutics has…”
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PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation by Ezzat, Kariem, EL Andaloussi, Samir, Zaghloul, Eman M., Lehto, Taavi, Lindberg, Staffan, Moreno, Pedro M. D., Viola, Joana R., Magdy, Tarek, Abdo, Rania, Guterstam, Peter, Sillard, Rannar, Hammond, Suzan M., Wood, Matthew J. A., Arzumanov, Andrey A., Gait, Michael J., Smith, C. I. Edvard, Hällbrink, Mattias, Langel, Ülo

“…Numerous human genetic diseases are caused by mutations that give rise to aberrant alternative splicing. Recently, several of these debilitating disorders have…”
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Nanotechnology approaches for gene transfer by Lundin, Karin E, Simonson, Oscar E, Moreno, Pedro M. D, Zaghloul, Eman M, Oprea, Iulian I, Svahn, Mathias G, Smith, C. I. Edvard

“…In both basic research as well as experimental gene therapy the need to transfer genetic material into a cell is of vital importance. The cellular compartment,…”
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Delivery of Splice Switching Oligonucleotides by Amphiphilic Chitosan-Based Nanoparticles by Moreno, Pedro M. D, Santos, Joyce C, Gomes, Carla P, Varela-Moreira, Aida, Costa, Artur, Leiro, Victoria, Mansur, Herman, Pêgo, Ana P

“…Splice switching oligonucleotides (SSOs) are a class of single-stranded antisense oligonucleotides (ssONs) being used as gene therapeutics and demonstrating…”
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Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes by Geny, Sylvain, Moreno, Pedro M D, Krzywkowski, Tomasz, Gissberg, Olof, Andersen, Nicolai K, Isse, Abdirisaq J, El-Madani, Amro M, Lou, Chenguang, Pabon, Y Vladimir, Anderson, Brooke A, Zaghloul, Eman M, Zain, Rula, Hrdlicka, Patrick J, Jørgensen, Per T, Nilsson, Mats, Lundin, Karin E, Pedersen, Erik B, Wengel, Jesper, Smith, C I Edvard

“…Targeting and invading double-stranded DNA with synthetic oligonucleotides under physiological conditions remain a challenge. Bis-locked nucleic acids…”
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A Peptide-based Vector for Efficient Gene Transfer In Vitro and In Vivo by Lehto, Taavi, Simonson, Oscar E, Mäger, Imre, Ezzat, Kariem, Sork, Helena, Copolovici, Dana-Maria, Viola, Joana R, Zaghloul, Eman M, Lundin, Per, Moreno, Pedro MD, Mäe, Maarja, Oskolkov, Nikita, Suhorutšenko, Julia, Smith, CI Edvard, Andaloussi, Samir EL

“…Finding suitable nonviral delivery vehicles for nucleic acid–based therapeutics is a landmark goal in gene therapy. Cell-penetrating peptides (CPPs) are one…”
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Temperature-Assisted Cyclic Hybridization (TACH): An Improved Method for Supercoiled DNA Hybridization by Oprea, Iulian I, Simonson, Oscar E, Moreno, Pedro M. D, Viola, Joana R, Lundin, Karin E, Smith, C. I. Edvard

“…Accurate hybridization is dependent on the ratio between sequence-specific and unspecific binding. Dissociation of unspecifically bound, while maintaining…”
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Functionalized chitosan derivatives as nonviral vectors: physicochemical properties of acylated N,N,N-trimethyl chitosan/oligonucleotide nanopolyplexes by Santos, Joyce C C, Moreno, Pedro M D, Mansur, Alexandra A P, Leiro, Victoria, Mansur, Herman S, Pêgo, Ana Paula

“…Cationic polymers have recently attracted attention due to their proven potential for nonviral gene delivery. In this study, we report novel biocompatible…”
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A high-throughput bioimaging study to assess the impact of chitosan-based nanoparticle degradation on DNA delivery performance by Gomes, Carla P., Varela-Moreira, Aida, Leiro, Victoria, Lopes, Cátia D.F., Moreno, Pedro M.D., Gomez-Lazaro, Maria, Pêgo, Ana P.

“…[Display omitted] By using imaging flow cytometry as a powerful statistical high-throughput technique we investigated the impact of degradation on the…”
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Antisense Oligonucleotides Modulating Activation of a Nonsense-Mediated RNA Decay Switch Exon in the ATM Gene by Kralovicova, Jana, Moreno, Pedro M D, Cross, Nicholas C P, Pêgo, Ana Paula, Vorechovsky, Igor

“…ATM (ataxia-telangiectasia, mutated) is an important cancer susceptibility gene that encodes a key apical kinase in the DNA damage response pathway. ATM…”
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Hydrogel-Assisted Antisense LNA Gapmer Delivery for In Situ Gene Silencing in Spinal Cord Injury by Moreno, Pedro M.D., Ferreira, Ana R., Salvador, Daniela, Rodrigues, Maria T., Torrado, Marília, Carvalho, Eva D., Tedebark, Ulf, Sousa, Mónica M., Amaral, Isabel F., Wengel, Jesper, Pêgo, Ana P.

“…After spinal cord injury (SCI), nerve regeneration is severely hampered due to the establishment of a highly inhibitory microenvironment at the injury site,…”
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Optimizing anti-gene oligonucleotide 'Zorro-LNA' for improved strand invasion into duplex DNA by Zaghloul, Eman M, Madsen, Andreas S, Moreno, Pedro M.D, Oprea, Iulian I, El-Andaloussi, Samir, Bestas, Burcu, Gupta, Pankaj, Pedersen, Erik B, Lundin, Karin E, Wengel, Jesper, Smith, C.I. Edvard

“…Zorro-LNA (Zorro) is a newly developed, oligonucleotide (ON)-based, Z-shaped construct with the potential of specific binding to each strand of duplex DNA. The…”
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synthetic snRNA m₃G-CAP enhances nuclear delivery of exogenous proteins and nucleic acids by Moreno, Pedro M.D, Wenska, Malgorzata, Lundin, Karin E, Wrange, Örjan, Strömberg, Roger, Smith, C.I. Edvard

“…Accessing the nucleus through the surrounding membrane poses one of the major obstacles for therapeutic molecules large enough to be excluded due to nuclear…”
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Enhancing Neuronal Cell Uptake of Therapeutic Nucleic Acids with Tetrahedral DNA Nanostructures by Martins, Ana S. G., Reis, Sara D., Benson, Erik, Domingues, Marco M., Cortinhas, João, Vidal Silva, Joana A., Santos, Sofia D., Santos, Nuno C., Pêgo, Ana P., Moreno, Pedro M. D.

“…The successful translation of therapeutic nucleic acids (NAs) for the treatment of neurological disorders depends on their safe and efficient delivery to…”
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Engineering a Novel Self-Assembled Multi-siRNA Nanocaged Architecture with Controlled Enzyme-Mediated siRNA Release by Moreno, Pedro M. D., Cortinhas, João, Martins, Ana S., Pêgo, Ana P.

“…The RNA interference (RNAi) chemical and structural design space has evolved since its original definitions. Although this has led to the development of RNAi…”
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Repeatable, Inducible Micro-RNA-Based Technology Tightly Controls Liver Transgene Expression by Oprea, Iulian I, Viola, Joana R, Moreno, Pedro M D, Simonson, Oscar E, Rodin, Sergey, Teller, Nathalie, Tryggvason, Karl, Lundin, Karin E, Girnita, Leonard, Smith, Carl Inge Edvard

“…Inducible systems for gene expression emerge as a new class of artificial vectors offering temporal and spatial exogenous control of gene expression. However,…”
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Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo by Andaloussi, Samir E L, Lehto, Taavi, Mäger, Imre, Rosenthal-Aizman, Katri, Oprea, Iulian I, Simonson, Oscar E, Sork, Helena, Ezzat, Kariem, Copolovici, Dana M, Kurrikoff, Kaido, Viola, Joana R, Zaghloul, Eman M, Sillard, Rannar, Johansson, Henrik J, Said Hassane, Fatouma, Guterstam, Peter, Suhorutšenko, Julia, Moreno, Pedro M D, Oskolkov, Nikita, Hälldin, Jonas, Tedebark, Ulf, Metspalu, Andres, Lebleu, Bernard, Lehtiö, Janne, Smith, C I Edvard, Langel, Ulo

“…While small interfering RNAs (siRNAs) have been rapidly appreciated to silence genes, efficient and non-toxic vectors for primary cells and for systemic in…”
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Design and application of bispecific splice-switching oligonucleotides by Bestas, Burcu, McClorey, Graham, Tedebark, Ulf, Moreno, Pedro M D, Roberts, Thomas C, Hammond, Suzan M, Smith, C I Edvard, Wood, Matthew J A, Andaloussi, Samir El

“…Targeting of pre-mRNA by short splice-switching oligonucleotides (SSOs) is increasingly being used as a therapeutic modality, one rationale being to disrupt…”
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Delivery of Antisense Oligonucleotides Mediated by a Hydrogel System: In Vitro and In Vivo Application in the Context of Spinal Cord Injury by Moreno, Pedro M D, Rodrigues, Teresa, Torrado, Marília, Amaral, Isabel F, Pêgo, Ana P

“…Biomaterials-based hydrogels are attractive drug-eluting vehicles in the context of RNA therapeutics, such as those utilizing antisense oligonucleotide or RNA…”
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