Search Results - "Moreno, Karlos X"

Real-time Detection of Hepatic Gluconeogenic and Glycogenolytic States Using Hyperpolarized [2-13C]Dihydroxyacetone by Moreno, Karlos X., Satapati, Santhosh, DeBerardinis, Ralph J., Burgess, Shawn C., Malloy, Craig R., Merritt, Matthew E.

“…Glycogenolysis and gluconeogenesis are sensitive to nutritional state, and the net direction of flux is controlled by multiple enzymatic steps. This delicate…”
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Conformational Analysis of Triazine Dendrimers: Using NMR Spectroscopy To Probe the Choreography of a Dendrimer’s Dance by Moreno, Karlos X, Simanek, Eric E

“…One-dimensional (1D) and two-dimensional (2D) NMR studies are used to probe the conformation of a melamine dendrimer bearing unique NMR signals from the core…”
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Nuclear spin hyperpolarization of the solvent using signal amplification by reversible exchange (SABRE) by Moreno, Karlos X., Nasr, Khaled, Milne, Mark, Sherry, A. Dean, Goux, Warren J.

“…[Display omitted] •Under acidic conditions the solvent can be hyperpolarized using SABRE.•Solvent hyperpolarization takes place by chemical exchange.•The…”
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Hyperpolarized δ‐[1‐13C]gluconolactone as a probe of the pentose phosphate pathway by Moreno, Karlos X., Harrison, Crystal E., Merritt, Matthew E., Kovacs, Zoltan, Malloy, Craig R., Sherry, A. Dean

“…The pentose phosphate pathway (PPP) is thought to be upregulated in trauma (to produce excess NADPH) and in cancer (to provide ribose for nucleotide…”
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Metabolism of hyperpolarized [1-13C]pyruvate through alternate pathways in rat liver by Jin, Eunsook S., Moreno, Karlos X., Wang, Jian-Xiong, Fidelino, Leila, Merritt, Matthew E., Sherry, A. Dean, Malloy, Craig R.

“…The source of hyperpolarized (HP) [13C]bicarbonate in the liver during metabolism of HP [1‐13C]pyruvate is uncertain and likely changes with physiology…”
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Competition of pyruvate with physiological substrates for oxidation by the heart: implications for studies with hyperpolarized [1-13C]pyruvate by Moreno, Karlos X, Sabelhaus, Scott M, Merritt, Matthew E, Sherry, A Dean, Malloy, Craig R

“…Carbon 13 nuclear magnetic resonance (NMR) isotopomer analysis was used to measure the rates of oxidation of long-chain fatty acids, ketones, and pyruvate to…”
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Multiband spectral‐spatial RF excitation for hyperpolarized [2‐13C]dihydroxyacetone 13C‐MR metabolism studies by Marco‐Rius, Irene, Cao, Peng, von Morze, Cornelius, Merritt, Matthew, Moreno, Karlos X., Chang, Gene‐Yuan, Ohliger, Michael A., Pearce, David, Kurhanewicz, John, Larson, Peder E. Z., Vigneron, Daniel B.

“…Purpose To develop a specialized multislice, single‐acquisition approach to detect the metabolites of hyperpolarized (HP) [2‐13C]dihydroxyacetone (DHAc) to…”
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Identification of diamine linkers with differing reactivity and their application in the synthesis of melamine dendrimers by Moreno, Karlos X., Simanek, Eric E.

“…Diamine linkers for the synthesis of dendrimers based on melamine were identified using competition reactions. The relative reactivity of the surveyed cyclic…”
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Hyperpolarized 13C NMR detects rapid drug-induced changes in cardiac metabolism by Khemtong, Chalermchai, Carpenter, Nicholas R., Lumata, Lloyd L., Merritt, Matthew E., Moreno, Karlos X., Kovacs, Zoltan, Malloy, Craig R., Sherry, A. Dean

“…Purpose The diseased myocardium lacks metabolic flexibility and responds to stimuli differently compared with healthy hearts. Here, we report the use of…”
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Production of hyperpolarized 13CO2 from [1-13C]pyruvate in perfused liver does reflect total anaplerosis but is not a reliable biomarker of glucose production by Moreno, Karlos X., Moore, Christopher L., Burgess, Shawn C., Sherry, A. Dean, Malloy, Craig R., Merritt, Matthew E.

“…In liver, 13 CO 2 can be generated from [1- 13 C]pyruvate via pyruvate dehydrogenase or anaplerotic entry of pyruvate into the TCA cycle followed by…”
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Interactions of 1,5-naphthyridine with Pd(en)Cl2 or [Pd(en)(H2O)2](NO3)2 in aqueous solution by Zhu, Shourong, Moreno, Karlos X, Jenkins, Roxanne M, Walmsley, Judith A

“…The nature of the complexes formed in aqueous solution between either Pd(en)Cl2 or [Pd(en)(H2O)2](NO3)2 and 1,5-naphthyridine (1,5-NAP), where en is…”
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Transfer of hyperpolarization from long T1 storage nuclei to short T1 neighbors using FLOPSY-8 by Moreno, Karlos X, Harrison, Crystal, Sherry, A Dean, Malloy, Craig R, Merritt, Matthew E

“…Nuclei with long T1s are optimal targets for dynamic nuclear polarization (DNP). Therefore, most of the agents used in metabolic imaging and spectroscopy…”
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Multiband spectral-spatial RF excitation for hyperpolarized [2- 13 C]dihydroxyacetone 13 C-MR metabolism studies: Spectral-Spatial Excitation of HP 13 C-Dihydroxyacetone by Marco-Rius, Irene, Cao, Peng, von Morze, Cornelius, Merritt, Matthew, Moreno, Karlos X., Chang, Gene-Yuan, Ohliger, Michael A., Pearce, David, Kurhanewicz, John, Larson, Peder E. Z., Vigneron, Daniel B.

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Multiband spectral-spatial RF excitation for hyperpolarized [2- super(13)C]dihydroxyacetone super(13)C-MR metabolism studies by Marco-Rius, Irene, Cao, Peng, von Morze, Cornelius, Merritt, Matthew, Moreno, Karlos X, Chang, Gene-Yuan, Ohliger, Michael A, Pearce, David, Kurhanewicz, John, Larson, Peder EZ, Vigneron, Daniel B

“…Purpose To develop a specialized multislice, single-acquisition approach to detect the metabolites of hyperpolarized (HP) [2- super(13)C]dihydroxyacetone…”
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Hyperpolarized super(13)C NMR detects rapid drug-induced changes in cardiac metabolism by Khemtong, Chalermchai, Carpenter, Nicholas R, Lumata, Lloyd L, Merritt, Matthew E, Moreno, Karlos X, Kovacs, Zoltan, Malloy, Craig R, Sherry, ADean

“…Purpose The diseased myocardium lacks metabolic flexibility and responds to stimuli differently compared with healthy hearts. Here, we report the use of…”
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Hyperpolarized 13 C NMR detects rapid drug‐induced changes in cardiac metabolism by Khemtong, Chalermchai, Carpenter, Nicholas R., Lumata, Lloyd L., Merritt, Matthew E., Moreno, Karlos X., Kovacs, Zoltan, Malloy, Craig R., Sherry, A. Dean

“…Purpose The diseased myocardium lacks metabolic flexibility and responds to stimuli differently compared with healthy hearts. Here, we report the use of…”
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Production of hyperpolarized 13 CO 2 from [1- 13 C]pyruvate in perfused liver does reflect total anaplerosis but is not a reliable biomarker of glucose production by Moreno, Karlos X, Moore, Christopher L, Burgess, Shawn C, Sherry, A Dean, Malloy, Craig R, Merritt, Matthew E

“…In liver, CO can be generated from [1- C] pyruvate via pyruvate dehydrogenase or anaplerotic entry of pyruvate into the TCA cycle followed by decarboxylation…”
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Production of hyperpolarized ^sup 13^CO2 from [1-^sup 13^C]pyruvate in perfused liver does reflect total anaplerosis but is not a reliable biomarker of glucose production by Moreno, Karlos X, Moore, Christopher L, Burgess, Shawn C, Sherry, A Dean, Malloy, Craig R, Merritt, Matthew E

“…In liver, ^sup 13^CO2 can be generated from [1-^sup 13^C]pyruvate via pyruvate dehydrogenase or anaplerotic entry of pyruvate into the TCA cycle followed by…”
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Transfer of hyperpolarization from long T sub(1 storage nuclei to short T) sub(1) neighbors using FLOPSY-8 by Moreno, Karlos X, Harrison, Crystal, Sherry, ADean, Malloy, Craig R, Merritt, Matthew E

“…Nuclei with long T sub(1s are optimal targets for dynamic nuclear polarization (DNP). Therefore, most of the agents used in metabolic imaging and spectroscopy…”
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Transfer of hyperpolarization from long T 1 storage nuclei to short T 1 neighbors using FLOPSY-8 by Moreno, Karlos X., Harrison, Crystal, Dean Sherry, A., Malloy, Craig R., Merritt, Matthew E.

“…[Display omitted] ► FLOPSY-8 can transfer hyperpolarized magnetization across a minimum of three bonds. ► Transfer of hyperpolarization depends on the number…”
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