Search Results - "Moreno, Imma"

Structure–activity relationships (SAR) and structure–kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists III: The role of a hydrogen-bond acceptor in long receptor residence times by Alonso, Juan Antonio, Andrés, Miriam, Bravo, Mónica, Buil, Maria Antonia, Calbet, Marta, Castro, Jordi, Eastwood, Paul R., Esteve, Cristina, Ferrer, Manel, Forns, Pilar, Gómez, Elena, González, Jacob, Lozoya, Estrella, Mir, Marta, Moreno, Imma, Petit, Silvia, Roberts, Richard S., Sevilla, Sara, Vidal, Bernat, Vidal, Laura, Vilaseca, Pere

“…The correct positioning and orientation of an hydrogen bond acceptor (HBA) in the tail portion of the biaryl series of CRTh2 antagonists is a requirement for…”
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Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure–Activity Relationships by Gràcia, Jordi, Buil, Maria Antonia, Castro, Jordi, Eichhorn, Peter, Ferrer, Manel, Gavaldà, Amadeu, Hernández, Begoña, Segarra, Victor, Lehner, Martin D, Moreno, Imma, Pagès, Lluís, Roberts, Richard S, Serrat, Jordi, Sevilla, Sara, Taltavull, Joan, Andrés, Miriam, Cabedo, Judit, Vilella, Dolors, Calama, Elena, Carcasona, Carla, Miralpeix, Montserrat

“…Cyclic nucleotide cAMP is a ubiquitous secondary messenger involved in a plethora of cellular responses to biological agents involving activation of adenylyl…”
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Structure–activity relationships (SAR) and structure–kinetic relationships (SKR) of pyrrolopiperidinone acetic acids as CRTh2 antagonists by Andrés, Miriam, Buil, Maria Antonia, Calbet, Marta, Casado, Oscar, Castro, Jordi, Eastwood, Paul R., Eichhorn, Peter, Ferrer, Manel, Forns, Pilar, Moreno, Imma, Petit, Silvia, Roberts, Richard S.

“…Pyrrolopiperidinone acetic acids (PPAs) were identified as highly potent CRTh2 receptor antagonists. In addition, many of these compounds displayed…”
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2-(1H-Pyrazol-1-yl)acetic acids as chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes (CRTh2) antagonists by Andrés, Miriam, Bravo, Mónica, Buil, Maria Antonia, Calbet, Marta, Castillo, Marcos, Castro, Jordi, Eichhorn, Peter, Ferrer, Manel, Lehner, Martin D., Moreno, Imma, Roberts, Richard S., Sevilla, Sara

“…In this manuscript, the synthesis and biological activity of a series of pyrazole acetic acid derivatives as CRTh2 antagonists is presented. Biological…”
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Biaryl analogues of teriflunomide as potent DHODH inhibitors by Erra, Montse, Moreno, Imma, Sanahuja, Jordi, Andrés, Miriam, Reinoso, Raquel F., Lozoya, Estrella, Pizcueta, Pilar, Godessart, Núria, Castro-Palomino, Julio Cesar

“…The structure–activity relationships of a novel series of biaryl dihydroorotate dehydrogenase (DHODH) inhibitors related to teriflunomide are disclosed. These…”
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Structure–activity relationships (SAR) and structure–kinetic relationships (SKR) of bicyclic heteroaromatic acetic acids as potent CRTh2 antagonists II: Lead optimization by Alonso, Juan Antonio, Andrés, Miriam, Bravo, Mónica, Calbet, Marta, Eastwood, Paul R., Eichhorn, Peter, Esteve, Cristina, Ferrer, Manel, Gómez, Elena, González, Jacob, Mir, Marta, Moreno, Imma, Petit, Silvia, Roberts, Richard S., Sevilla, Sara, Vidal, Bernat, Vidal, Laura, Vilaseca, Pere, Zanuy, Miriam

“…Extensive structure–activity relationship (SAR) and structure–kinetic relationship (SKR) studies in the bicyclic heteroaromatic series of CRTh2 antagonists led…”
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2-(1H-Pyrazol-4-yl)acetic acids as CRTh2 antagonists by Andrés, Miriam, Bravo, Mónica, Buil, Maria Antonia, Calbet, Marta, Castro, Jordi, Domènech, Teresa, Eichhorn, Peter, Ferrer, Manel, Gómez, Elena, Lehner, Martin D., Moreno, Imma, Roberts, Richard S., Sevilla, Sara

“…High throughput screening identified the pyrazole-4-acetic acid substructure as CRTh2 receptor antagonists. Optimisation of the compounds uncovered a tight SAR…”
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Discovery of a novel class of zwitterionic, potent, selective and orally active S1P1 direct agonists by Aguilar, Nuria, Mir, Marta, Grima, Pedro M., López, Manel, Segarra, Victor, Esteban, Laia, Moreno, Imma, Godessart, Nuria, Tarrasón, Gema, Domenech, Teresa, Vilella, Dolors, Armengol, Clara, Córdoba, Mònica, Sabaté, Mar, Casals, Daniel, Domínguez, Maria

“…Amido-1,3,4-thiadiazoles were identified as a novel structural class of potent and selective sphingosine-1-phosphate receptor subtype-1 agonists. Starting from…”
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Impact of ABO incompatibility on allogeneic peripheral blood progenitor cell transplantation after reduced intensity conditioning by Canals, Carmen, Muñiz-Díaz, Eduardo, Martínez, Clara, Martino, Rodrigo, Moreno, Imma, Ramos, Adelaida, Arilla, Marina, Boto, Neus, Pastoret, Concepción, Remacha, Angel, Sierra, Jorge, Madoz, Pedro

“…BACKGROUND:  Most studies indicate that ABO incompatibility has no effect on the clinical outcome after allogeneic peripheral blood progenitor cell (PBPC)…”
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