New pharmacological insights of Galactia glaucescens

New pharmacological insights of Galactia glaucescens

Galactia glaucescens leaves are popularly used against snakebites in Brazil. The hydroethanolic extract from aerial parts of G. glaucescens (HEGg) was assayed against the neurotoxicity and myotoxicity induced by Bothrops jararacussu venom. A traditional myographic technique was applied for neurotoxi...

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Bibliographic Details
Published in:Natural product research Vol. 33; no. 16; pp. 2389 - 2393
Main Authors: dos Santos, Márcio G., Moreno, Felipe S., de Oliveira, Akila L., Oliveira, Isadora C. F., Tribuiani, Natália, Cogo, José C., Scriboni, Andreia B., Cogo-Müller, Karina, San Feliciano, Arturo, Jose Bonomini, Tiago, Fernandes, João B., Oshima-Franco, Yoko
Format: Journal Article
Language:English
Published: England Taylor & Francis 18-08-2019
Taylor & Francis Ltd
Subjects:
Antiinfectives and antibacterials
Antimicrobial
antiophidian
Bothrops jararacussu
E coli
Galactia
Galactia glaucescens
leaves 3-foliolate
Light microscopy
Muscles
neglected tropical disease
Neurotoxicity
Neutralization
Pharmacology
Pseudomonas aeruginosa
Rutin
Venom
Antimicrobial
neglected tropical disease
Rutin
leaves 3-foliolate
antiophidian
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Summary:Galactia glaucescens leaves are popularly used against snakebites in Brazil. The hydroethanolic extract from aerial parts of G. glaucescens (HEGg) was assayed against the neurotoxicity and myotoxicity induced by Bothrops jararacussu venom. A traditional myographic technique was applied for neurotoxicity and the resulting muscles were treated routinely by light microscopy analysis for myotoxicity. Additionally, the antimicrobial potential of HEGg was evaluated against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa strains, as well as Rutin was isolated for the first time in this specie using chromatographic and spectroscopic methods and its antiophidian property was assessed. HEGg totally prevents the neurotoxicity and myotoxicity effects caused by B. jararacussu, but did not show any antimicrobial effect. Concluding, HEGg and Rutin were able to counteract the toxic effects of the venom and confirmed the antiophidian potential, but not antimicrobial, of G. glaucescens as an alternative for neutralization of B. jararacussu venom.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2018.1443086