miRNA in the Diagnosis and Treatment of Critical Limb Ischemia

Chronic threatening limb ischemia of the inferior limbs (CLTI) is the final stage of peripheral arterial disease (PAD) and is one of the most feared atherosclerotic manifestations because if left untreated, in time, it can lead to amputation. Although there are currently numerous treatment technique...

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Bibliographic Details
Published in:	Biomedicines Vol. 12; no. 9; p. 2026
Main Authors:	Popescu, Alexandra Ioana, Rață, Andreea Luciana, Vlad, Daliborca, Vlad, Cristian, Popescu, Roxana, Onofrei, Ramona Roxana, Morelli, Marialuisa, Pantea, Stelian, Barac, Sorin
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 04-09-2024 MDPI
Subjects:	Amputation Arteriosclerosis Atherosclerosis Biomarkers Cardiovascular system Care and treatment chronic threatening limb ischemia Diabetes Disease Ethylenediaminetetraacetic acid Gene expression Health aspects Hypertension Ischemia MicroRNA MicroRNAs miRNA Mortality Pathology Scientific equipment and supplies industry Vascular surgery United States Romania United States > US atherosclerosis microRNA chronic threatening limb ischemia
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Summary:	Chronic threatening limb ischemia of the inferior limbs (CLTI) is the final stage of peripheral arterial disease (PAD) and is one of the most feared atherosclerotic manifestations because if left untreated, in time, it can lead to amputation. Although there are currently numerous treatment techniques, both open and endovascular, it is a pathology that has no underlying treatment. Therefore, current studies are very much focused on new therapeutic possibilities that can be applied in the early stages of the atherosclerotic process. In numerous studies in the literature, miRNAs have been identified as important markers of atherosclerosis. The present study aims to identify the expression of three miRNAs- , -in patients with chronic limb-threatening ischemia in the pre- and post-revascularization periods. The aim of the study is to identify whether these three markers play a role in critical ischemia and whether they have the potential for future use in new treatments of this pathology.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2227-9059 2227-9059
DOI:	10.3390/biomedicines12092026