Search Results - "Morellato, Alessandro"
-
1
The p140Cap adaptor protein as a molecular hub to block cancer aggressiveness
Published in Cellular and molecular life sciences : CMLS (01-02-2021)“…The p140Cap adaptor protein is a scaffold molecule encoded by the SRCIN1 gene, which is physiologically expressed in several epithelial tissues and in the…”
Get full text
Journal Article -
2
Cholesterol and Its Derivatives: Multifaceted Players in Breast Cancer Progression
Published in Frontiers in oncology (26-05-2022)“…Cholesterol is an essential lipid primarily synthesized in the liver through the mevalonate pathway. Besides being a precursor of steroid hormones, bile acid,…”
Get full text
Journal Article -
3
The role of tumor microenvironment in drug resistance: emerging technologies to unravel breast cancer heterogeneity
Published in Frontiers in oncology (17-05-2023)“…Breast cancer is a highly heterogeneous disease, at both inter- and intra-tumor levels, and this heterogeneity is a crucial determinant of malignant…”
Get full text
Journal Article -
4
p140Cap inhibits β-Catenin in the breast cancer stem cell compartment instructing a protective anti-tumor immune response
Published in Nature communications (11-05-2023)“…The p140Cap adaptor protein is a tumor suppressor in breast cancer associated with a favorable prognosis. Here we highlight a function of p140Cap in…”
Get full text
Journal Article -
5
The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma
Published in Cell death and differentiation (01-02-2020)“…Neuroblastoma is the most common extra-cranial pediatric solid tumor, responsible for 13–15% of pediatric cancer death. Its intrinsic heterogeneity makes it…”
Get full text
Journal Article -
6
p140Cap modulates the mevalonate pathway decreasing cell migration and enhancing drug sensitivity in breast cancer cells
Published in Cell death & disease (20-12-2023)“…p140Cap is an adaptor protein involved in assembling multi-protein complexes regulating several cellular processes. p140Cap acts as a tumor suppressor in…”
Get full text
Journal Article -
7
Correction to: The SRCIN1/p140Cap adaptor protein negatively regulates the aggressiveness of neuroblastoma
Published in Cell death and differentiation (01-04-2020)“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
Get full text
Journal Article -
8
p140Cap Controls Female Fertility in Mice Acting via Glutamatergic Afference on Hypothalamic Gonadotropin-Releasing Hormone Neurons
Published in Frontiers in neuroscience (14-02-2022)“…p140Cap, encoded by the gene ( , is an adaptor/scaffold protein highly expressed in the mouse brain, participating in several pre- and post-synaptic…”
Get full text
Journal Article -
9
Synaptic Interactome Mining Reveals p140Cap as a New Hub for PSD Proteins Involved in Psychiatric and Neurological Disorders
Published in Frontiers in molecular neuroscience (30-06-2017)“…Altered synaptic function has been associated with neurological and psychiatric conditions including intellectual disability, schizophrenia and autism spectrum…”
Get full text
Journal Article -
10
Dissecting the Shared and Context-Dependent Pathways Mediated by the p140Cap Adaptor Protein in Cancer and in Neurons
Published in Frontiers in cell and developmental biology (15-10-2019)“…The p140Cap adaptor protein is a scaffold molecule physiologically expressed in few epithelial tissues, such as the mammary gland, and in differentiated…”
Get full text
Journal Article -
11
p140Cap Regulates the Composition and Localization of the NMDAR Complex in Synaptic Lipid Rafts
Published in The Journal of neuroscience (21-09-2022)“…The NMDARs are key players in both physiological and pathologic synaptic plasticity because of their involvement in many aspects of neuronal transmission as…”
Get full text
Journal Article -
12
p140Cap Regulates GABAergic Synaptogenesis and Development of Hippocampal Inhibitory Circuits
Published in Cerebral cortex (New York, N.Y. 1991) (01-01-2019)“…Abstract The neuronal scaffold protein p140Cap was investigated during hippocampal network formation. p140Cap is present in presynaptic GABAergic terminals and…”
Get full text
Journal Article -
13
The N-terminal domain of the adaptor protein p140Cap interacts with Tiam1 and controls Tiam1/Rac1 axis
Published in American journal of cancer research (01-01-2020)“…The p140Cap adaptor protein, encoded by the gene, negatively controls tumor progression, as demonstrated in the subgroup of -amplified breast cancers and in…”
Get full text
Journal Article