Search Results - "Moreland, Robert S"

Effect of type II diabetes on male rat bladder contractility by Kendig, Derek M, Ets, Hillevi K, Moreland, Robert S

“…Type II diabetes is the most prevalent form of diabetes. One of the primary complications of diabetes that significantly affects quality of life is bladder…”
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Ca2+ sensitization pathways accessed by cholinergic neurotransmission in the murine gastric fundus by Bhetwal, Bhupal P., Sanders, Kenton M., An, Changlong, Trappanese, Danielle M., Moreland, Robert S., Perrino, Brian A.

“…Key points •  In smooth muscles, the sensitivity of contraction to Ca2+ can be increased by the phosphorylation of CPI‐17 and MYPT1, resulting in the…”
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Regulation of mitogen-activated protein kinase by protein kinase C and mitogen-activated protein kinase phosphatase-1 in vascular smooth muscle by Trappanese, Danielle M, Sivilich, Sarah, Ets, Hillevi K, Kako, Farah, Autieri, Michael V, Moreland, Robert S

“…Vascular smooth muscle contraction is primarily regulated by phosphorylation of myosin light chain. There are also modulatory pathways that control the final…”
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Carbachol-induced rabbit bladder smooth muscle contraction: roles of protein kinase C and Rho kinase by Wang, Tanchun, Kendig, Derek M, Smolock, Elaine M, Moreland, Robert S

“…Smooth muscle contraction is regulated by phosphorylation of the myosin light chain (MLC) catalyzed by MLC kinase and dephosphorylation catalyzed by MLC…”
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Effect of Estrogen on Molecular and Functional Characteristics of the Rodent Vaginal Muscularis by Basha, Maureen E., Chang, Shaohua, Burrows, Lara J., Lassmann, Jenny, Wein, Alan J., Moreland, Robert S., Chacko, Samuel

“…Vaginal atrophy is a consequence of menopause; however, little is known concerning the effect of a decrease in systemic estrogen on vaginal smooth muscle…”
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Detrusor contractility to parasympathetic mediators is differentially altered in the compensated and decompensated states of diabetic bladder dysfunction by Klee, Nicole S, Moreland, Robert S, Kendig, Derek M

“…Diabetic bladder dysfunction (DBD) affects up to 50% of all patients with diabetes, characterized by symptoms of both overactive and underactive bladder…”
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Phorbol 12,13-dibutyrate-induced, protein kinase C-mediated contraction of rabbit bladder smooth muscle by Wang, Tanchun, Kendig, Derek M, Trappanese, Danielle M, Smolock, Elaine M, Moreland, Robert S

“…Contraction of bladder smooth muscle is predominantly initiated by M(3) muscarinic receptor-mediated activation of the G(q/11)-phospholipase C β-protein kinase…”
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N1-Alkylated 3,4-dihydropyrimidine-2(1 H)-ones: Convenient one-pot selective synthesis and evaluation of their calcium channel blocking activity by Singh, Kamaljit, Arora, Divya, Poremsky, Elizabeth, Lowery, Jazmyne, Moreland, Robert S.

“…It has been found that selective N1-alkylation of 3,4-dihydropyrimidine-2(1 H)-ones can be achieved under solvent-less, mild phase transfer catalytic (PTC)…”
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Phosphatidylinositol 3-kinase modulates vascular smooth muscle contraction by calcium and myosin light chain phosphorylation-independent and -dependent pathways by Su, Xiaoling, Smolock, Elaine M, Marcel, Kristi N, Moreland, Robert S

“…Regulation of smooth muscle contraction involves a number of signaling mechanisms that include both kinase and phosphatase reactions. The goal of the present…”
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Effect of partial outlet obstruction on rabbit urinary bladder smooth muscle function by Su, Xiaoling, Stein, Raymund, Stanton, Michaela C, Zderic, Stephen, Moreland, Robert S

“…Bladder outlet obstruction secondary to benign prostate hyperplasia is associated with many cellular changes. This study was designed to determine whether…”
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An Efficacious Protocol for 4‐Substituted 3,4‐Dihydropyrimidinones: Synthesis and Calcium Channel Binding Studies by Singh, Kamaljit, Arora, Divya, Falkowski, Danielle, Liu, Qingxin, Moreland, Robert S.

“…Ethyl 1,2‐dihydro‐1,6‐dimethyl/6‐methyl‐2‐oxopyrimidine‐5‐carboxylates react with C‐nucleophiles as well as the anion of the enantiopure chiral auxiliary…”
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Sphingosine-1-phosphate induced contraction of bladder smooth muscle by Kendig, Derek M., Matsumoto, Alec K., Moreland, Robert S.

“…Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that contracts most smooth muscles. Although S1P has been shown to contract bladder smooth muscle,…”
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Highly regioselective synthesis of N-3 organophosphorous derivatives of 3,4-dihydropyrimidin-2(1H)-ones and their calcium channel binding studies by Singh, Kamaljit, Singh, Kawaljit, Trappanese, Danielle M., Moreland, Robert S.

“…A series of novel N-3 substituted 3,4-dihydropyrimidin-2(1H)-ones derivatives bearing diaminophosphinyl, phosphonate and phosphorous containing heterocycles…”
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Sustained Contraction in Vascular Smooth Muscle by Activation of L-type Ca2+ Channels Does Not Involve Ca2+ Sensitization or Caldesmon by Ets, Hillevi K., Seow, Chun Y., Moreland, Robert S.

“…Vascular smooth muscle (VSM) is unique in its ability to maintain an intrinsic level of contractile force, known as tone. Vascular tone is believed to arise…”
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Partial bladder outlet obstruction abolishes the receptor- and G protein-dependent increase in calcium sensitivity in rabbit bladder smooth muscle by Stanton, Michaela C, Delaney, Daniel, Zderic, Stephen A, Moreland, Robert S

“…Partial bladder outlet obstruction (PBOO) alters the function of the whole bladder and produces specific alterations in the contractility of the bladder smooth…”
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Corrigendum: Sustained Contraction in Vascular Smooth Muscle by Activation of L-type Ca2+ Channels Does Not Involve Ca2+ Sensitization or Caldesmon by Ets, Hillevi K., Seow, Chun Y., Moreland, Robert S.

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Bladder smooth muscle organ culture preparation maintains the contractile phenotype by Wang, Tanchun, Kendig, Derek M, Chang, Shaohua, Trappanese, Danielle M, Chacko, Samuel, Moreland, Robert S

“…Smooth muscle cells, when subjected to culture, modulate from a contractile to a secretory phenotype. This has hampered the use of cell culture for molecular…”
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Quinine inhibits vascular contraction independent of effects on calcium or myosin phosphorylation by Adegunloye, Banji, Lamarre, Eric, Moreland, Robert S

“…This report contains results of studies designed to determine whether quinine has direct effects on myofilament Ca2+ sensitization in addition to effects on…”
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siRNA-mediated knockdown of h-caldesmon in vascular smooth muscle by Smolock, Elaine M, Trappanese, Danielle M, Chang, Shaohua, Wang, Tanchun, Titchenell, Paul, Moreland, Robert S

“…Smooth muscle contraction involves phosphorylation of the regulatory myosin light chain. However, this thick-filament system of regulation cannot account for…”
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Functional and molecular consequences of ionizing irradiation on large conductance Ca2+-activated K+ channels in rat aortic smooth muscle cells by Soloviev, Anatoly, Tishkin, Sergey, Ivanova, Irina, Zelensky, Sergey, Dosenko, Victor, Kyrychenko, Sergey, Moreland, Robert S

“…The goal of this study was to evaluate the influence of gamma-irradiation on Ca(2+)-activated K(+) channel (BK(Ca)) function and expression in rat thoracic…”
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