Search Results - "Moreland, Kirby T"

Selective Imaging of Lung Macrophages Using [11C]PBR28-Based Positron Emission Tomography by Chen, Delphine L., Agapov, Eugene, Wu, Kangyun, Engle, Jacquelyn T., Solingapuram Sai, Kiran Kumar, Arentson, Elizabeth, Spayd, Katherine J., Moreland, Kirby T., Toth, Kelsey, Byers, Derek E., Pierce, Richard A., Atkinson, Jeffrey J., Laforest, Richard, Gelman, Andrew E., Holtzman, Michael J.

“…Purpose We tested whether the translocator protein (TSPO)-targeted positron emission tomography (PET) tracer, N-acetyl-N-(2-[ 11…”
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Structural insights into the stereochemistry of the cyclooxygenase reaction by Kurumbail, Ravi G, Kiefer, James R, Pawlitz, Jennifer L, Moreland, Kirby T, Stegeman, Roderick A, Hood, William F, Gierse, James K, Stevens, Anna M, Goodwin, Douglas C, Rowlinson, Scott W, Marnett, Lawrence J, Stallings, William C

“…Cyclooxygenases are bifunctional enzymes that catalyse the first committed step in the synthesis of prostaglandins, thromboxanes and other eicosanoids. The two…”
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A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors by Walker, M C, Kurumbail, R G, Kiefer, J R, Moreland, K T, Koboldt, C M, Isakson, P C, Seibert, K, Gierse, J K

“…Cyclo-oxygenase (COX) enzymes are the targets for non-steroidal anti-inflammatory drugs (NSAIDs). These drugs demonstrate a variety of inhibitory mechanisms,…”
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A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors by WALKER, Mark C., KURUMBAIL, Ravi G., KIEFER, James R., MORELAND, Kirby T., KOBOLDT, Carol M., ISAKSON, Peter C., SEIBERT, Karen, GIERSE, James K.

“…Cyclo-oxygenase (COX) enzymes are the targets for non-steroidal anti-inflammatory drugs (NSAIDs). These drugs demonstrate a variety of inhibitory mechanisms,…”
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Crystallization of recombinant cyclo-oxygenase-2 by Stevens, Anna M., Pawlitz, Jennifer L., Kurumbail, Ravi G., Gierse, James K., Moreland, Kirby T., Stegeman, Roderick A., Loduca, Jina Y., Stallings, William C.

“…The integral membrane protein, prostaglandin H 2 synthase, or cyclo-oxygenase (COX), catalyses the first step in the conversion of arachidonic acid to…”
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Crystal structures of cyclooxygenase-2 variants with diarylheterocycle inhibitors: Contribution of the side pocket for selectivity by Kurumbail, Ravi G., Pawlitz, Jennifer L., Kiefer, James R., Stegeman, Roderick A., Stevens, Anna M., Gierse, James K., Moreland, Kirby T., Walker, Mark C., Rowlinson, Scott W., Marnett, Lawrence J., Stallings, William C.

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A proposed three step mechanism for inhibition of cyclooxygenase-2 by Walker, Mark C., Kurumbail, Ravi G., Hood, William F., Monahan, Joseph B., Pawlitz, Jennifer L., Stegeman, Roderick A., Stevens, Anna M., Kiefer, James R., Koboldt, Carol M., Moreland, Kirby T., Rowlinson, Scott, Mamett, Lawrence J., Pierce, Jennifer L., Carter, Jeffery S., Talley, John J., Isakson, Peter C., Seibert, Karen, Gierse, James K.

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