Search Results - "Moreland, D.W."

Effect of mutating aspart ate 103 to glutamate or asparagine in the Hm2 subtype on binding of agonists and antagonists of varied pKa and subtype selectivity by Spencer, C.J., Schwarz, R.D., Moreland, D.W., Thomas, A.J., Tecle, H.

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Identification and characterization of m4 selective muscarinic antagonists by Augelli-Szafran, C.E., Moreland, D.W., Nelson, C.B., Penvose-Yi, J.R., Schwarz, R.D., Jaen, J.C.

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Aryleneyne 1-azabicyclo[2.2.1]heptan-3-one oximes: Potent muscarinic agonists by Tecle, H., Lauffer, D.J., Davis, R.E., Mirzadegan, T., Moreland, D.W., Schwarz, R.D., Thomas, A.J., Raby, C., Jaen, J.C.

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Identification and characterization of m1 selective muscarinic antagonists by Augelli-Szafran, C.E., Blankley, C.J., Jaen, J.C., Moreland, D.W., Nelson, C.B., Penvose, J.R., Schwarz, R.D., Thomas, A.J.

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Synthesis and SAR of bulky 1-azabicyclo[2.2.1]-3-one oximes as muscarinic receptor subtype selective agonists by Tecle, H, Lauffer, D J, Mirzadegan, T, Moos, W H, Moreland, D W, Pavia, M R, Schwarz, R D, Davis, R E

“…The synthesis of a series of potent and efficacious 1-azabicyclo[2.2.1]heptan-3-one oxime muscarinic agonists is described. The oximes have extended appendages…”
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CI-1017, a functionally M1-selective muscarinic agonist: design, synthesis, and preclinical pharmacology by Tecle, H, Schwarz, R.D, Barrett, S.D, Callahan, M.J, Caprathe, B.W, Davis, R.E, Doyle, P, Emmerling, M, Lauffer, D.J, Mirzadegan, T, Moreland, D.W, Lipiniski, W, Nelson, C, Raby, C, Spencer, C, Spiegel, K, Thomas, A.J, Jaen, J.C

“…The five muscarinic receptor subtypes (M1–M5) are characterized by seven helices that define a transmembrane cavity which serves as the binding pocket for…”
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(±)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-methyl-5-aryl-2-penten-4-ynyl) oximes: Potent muscarinic agonists by Tecle, H., Lauffer, D.J., Davis, R.E., Mirzadegan, T., Moreland, D.W., Schwan, R.D., Thomas, A.J., Raby, C., Eubanks, D., Brann, M.R., Jaen, J.C.

“…Synthesis and SAR of a new class of 1-azabicyclo[2.2.1]heptan-3-one, O-(3-methyl-5-aryl-2-penten-4-ynyl) oxime muscarinic agonists are described. Depending on…”
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Z-(±)-1-azabicyclo[2.2.1]heptan-3-one, O-(3-aryl-2-propynyl) oximes as potential m1-subtype selective muscarinic agonists by Tecle, H., Jaen, J.C., Augelli-Szafran, C., Barrett, S.D., Caprathe, B.W., Lauffer, D.J., Mirzadegan, T., Moos, W.H., Moreland, D.W., Pavia, M.R., Schwarz, R.D., Thomas, A.J., Davis, R.E.

“…The synthesis and SAR of a series of Z-(±)-1-azabicyclo[2.2.1]heptan-3-one, O-(3-aryl-2-propynyl) oximes are described. The biochemistry and pharmacology of PD…”
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