Search Results - "Moreira, Lorrane Kelle"

Antinociceptive and anti-inflammatory effects of extract of Celtis iguanaea (Jacq.) Sargent leaves in mice by MORAES, WEULLER FILHO DE, SILVA, DAIANY PRISCILLA B. DA, FLORENTINO, IZIARA F., ALMEIDA, DIONYS S., MOREIRA, LORRANE KELLE S., NASCIMENTO, MARCUS VINÍCIUS M., CARVALHO, PABLINNY M.G. DE, COUTO, RENÊ O. DO, PAULA, JOSÉ R. DE, COSTA, ELSON A.

“…Abstract The antinociceptive and anti-inflammatory activities of crude ethanolic extract of Celtis iguanaea leaves and their active fractions are reported. The…”
Get full text

Potential antidepressant-like effect of piperazine derivative LQFM212 in mice: Role of monoaminergic pathway and brain-derived neurotrophic factor by Moreira, Lorrane Kelle da Silva, de Brito, Adriane Ferreira, da Silva, Dayane Moreira, Siqueira, Lorrayne, da Silva, Daiany Priscilla Bueno, Cardoso, Carina Sofia, Florentino, Iziara Ferreira, de Carvalho, Pablinny Moreira Galdino, Ghedini, Paulo César, Menegatti, Ricardo, Costa, Elson Alves

“…[Display omitted] •LQFM212, a piperazine derivative, has an antidepressant-like effect in mice.•The monoaminergic pathway play an important role on this…”
Get full text

Anxiolytic- and antidepressant-like effects of new phenylpiperazine derivative LQFM005 and its hydroxylated metabolite in mice by Moreira, Lorrane Kelle da Silva, Silva, Rafaela Ribeiro, da Silva, Dayane Moreira, Mendes, Mirella Andrade Silva, de Brito, Adriane Ferreira, de Carvalho, Flávio Souza, Sanz, Germán, Rodrigues, Marcella Ferreira, da Silva, Artur Christian Garcia, Thomaz, Douglas Vieira, de Oliveira, Valéria, Vaz, Boniek Gontijo, Lião, Luciano Morais, Valadares, Marize Campos, Gil, Eric de Souza, Costa, Elson Alves, Noël, François, Menegatti, Ricardo

“…The current treatments available for anxiety and depression are only palliative. Full remission has remained elusive, characterizing unmet medical needs. In…”
Get full text

Preclinical data on morpholine (3,5-di-tertbutyl-4-hydroxyphenyl) methanone induced anxiolysis by Cabral, Iara Barbosa, de Lima Moreira, Caroline Vitória, Rodrigues, Ana Carolina Cavalcante, da Silva Moreira, Lorrane Kelle, Pereira, Jhon Kennedy Alves, Gomides, Christian Dias, Lião, Luciano M., Machado, Lucas S., Vaz, Boniek G., da Cunha, Luiz Carlos, de Oliveira Neto, Jerônimo Raimundo, da Silva-Júnior, Edeildo Ferreira, de Aquino, Thiago Mendonça, da Silva Santos-Júnior, Paulo Fernando, Silva, Osmar N., da Rocha, Fábio Fagundes, Costa, Elson Alves, Menegatti, Ricardo, Fajemiroye, James O.

“…Trimetozine is used to be indicated for the treatment of mental illnesses, particularly anxiety. The present study provides data on the pharmacological profile…”
Get full text

Mechanism of action involved in the anxiolytic-like effects of Hibalactone isolated from Hydrocotyle umbellata L by Gabriel de Oliveira, Matheus, Kelle da Silva Moreira, Lorrane, Turones, Larissa Cordova, de Souza Almeida, Dionys, Martins, Aline Nazareth, Silva Oliveira, Thiago Levi, Barreto da Silva, Vinicius, Borges, Leonardo Luiz, Costa, Elson Alves, Realino de Paula, José

“…Background and aim: Hibalactone (HB) is a lignan related to the anxiolytic-like effects of Hydrocotyle umbellata L. However, there is a need to understand…”
Get full text

Tert-butyl 4-((1-phenyl-1H-pyrazol-4-yl) methyl) piperazine-1-carboxylate (LQFM104)– New piperazine derivative with antianxiety and antidepressant-like effects: Putative role of serotonergic system by da Silva, Dayane Moreira, Sanz, Germán, Vaz, Boniek Gontijo, de Carvalho, Flávio Silva, Lião, Luciano Morais, de Oliveira, Danillo Ramos, Moreira, Lorrane Kelle da Silva, Cardoso, Carina Sofia, de Brito, Adriane Ferreira, da Silva, Daiany Priscilla Bueno, da Rocha, Fabio Fagundes, Santana, Ianca Gontijo Cavalcante, Galdino, Pablinny Moreira, Costa, Elson Alves, Menegatti, Ricardo

“…[Display omitted] •LQFM104 is a new synthesized psychoactive piperazine derivative.•LQFM104 has anxiolytic- and antidepressant-like activities in mice.•These…”
Get full text

Anti-inflammatory and antinociceptive effects, and safety toxicological profile of a new paracetamol analog, LQFM291 by Turones, Larissa Córdova, Machado, Lucas S., Vaz, Boniek G., de Almeida R. Oliveira, Gerlon, da Silva Moreira, Lorrane Kelle, Almeida, Dionys de Souza, Martins, Aline Nazareth, Fajemiroye, James Oluwagbamigbe, Martins, José Luís R., Ghedini, Paulo César, Campos, Hericles Mesquita, dos Santos, Fernanda Cristina A., da Silva, Cinthia Rio Branco, Lião, Luciano M., Gil, Eric de Souza, Costa, Elson Alves, Menegatti, Ricardo

“…In the scope of a research program with the goal of developing treatments for inflammatory diseases, the pharmacological evaluation of LQFM291, designed by…”
Get full text

Development of pyrazole derivatives in the management of inflammation by Turones, Larissa Córdova, Martins, Aline Nazareth, Moreira, Lorrane Kelle da Silva, Fajemiroye, James Oluwagbamigbe, Costa, Elson Alves

“…The therapeutic limitations and poor management of inflammatory conditions are anticipated to impact patients negatively over the coming decades. Following the…”
Get full text

Anxiolytic-like effects and impact on memory of Hydrocotyle umbellata L. spray-dried extract in mice and toxicological assessment by de Oliveira, Matheus Gabriel, Moreira, Lorrane Kelle da Silva, Costa, Gessyca Gonçalves, Barbosa, Bruno Franco Fernandes, Vencio, Rafael Caiado Caixeta, Fajemiroye, James Oluwagbamigbe, Costa, Elson Alves, de Oliveira, Gisele Augusto Rodrigues, Chen-Chen, Lee, Gomes, Clayson Moura, Borges, Leonardo Luiz, da Silva, Vinicius Barreto, de Paula, José Realino

“…•The anxiolytic-like activity of the extract was reverted by pretreatment with flumazenil, but not with WAY-100,635.•No signs of memory impairment on short-…”
Get full text

Protective effects of chrysin against the neurotoxicity induced by aluminium: In vitro and in vivo studies by Campos, Hericles Mesquita, da Costa, Michael, da Silva Moreira, Lorrane Kelle, da Silva Neri, Hiasmin Franciely, Branco da Silva, Cinthia Rio, Pruccoli, Letizia, dos Santos, Fernanda Cristina Alcantara, Costa, Elson Alves, Tarozzi, Andrea, Ghedini, Paulo César

“…Chronic exposure to aluminium (Al) can contribute to the progression of several neurological and neurodegenerative diseases. Al is a metal that promotes…”
Get full text

LQFM212, a piperazine derivative, exhibits potential antioxidant effect as well as ameliorates LPS-induced behavioral, inflammatory and oxidative changes by Moreira, Lorrane Kelle da Silva, Turones, Larissa Córdova, Campos, Hericles Mesquita, Nazareth, Aline Martins, Thomaz, Douglas Vieira, Gil, Eric de Souza, Ghedini, Paulo César, Rocha, Fábio Fagundes da, Menegatti, Ricardo, Fajemiroye, James Oluwagbamigbe, Costa, Elson Alves

“…Oxidative stress, impaired antioxidant defense and neuroinflammation are often associated with the onset and progression of neuropsychiatric diseases…”
Get full text

Chemical characterization and pharmacological assessment of polysaccharide free, standardized cashew gum extract (Anacardium occidentale L.) by da Silva, Daiany Priscilla Bueno, Florentino, Iziara Ferreira, da Silva Moreira, Lorrane Kelle, Brito, Adriane Ferreira, Carvalho, Verônica Vale, Rodrigues, Marcella Ferreira, Vasconcelos, Géssica Adriana, Vaz, Boniek Gontijo, Pereira-Junior, Marcus Antônio, Fernandes, Kátia Flávia, Costa, Elson Alves

“…The cashew gum (Anacardium occidentale L.) is used in traditional Brazilian medicine in the treatment of inflammatory conditions, asthma, diabetes, and…”
Get full text

Neuropharmacological assessment in mice and molecular docking of piperazine derivative LQFM212 by Moreira, Lorrane Kelle, de Brito, Adriane Ferreira, Fontana, Crisciele, de Carvalho, Flávio Souza, Sanz, Germán, Vaz, Boniek Gontijo, Lião, Luciano Morais, da Rocha, Fábio Fagundes, Verli, Hugo, Menegatti, Ricardo, Costa, Elson Alves

“…•LQFM212 is a new piperazine derivative with pharmacological central activity.•LQFM212 has an anxiolytic-like activity with no cognitive impairment.•The action…”
Get full text

Neuropharmacological Activity of the New Piperazine Derivative 2-(4-((1- Phenyl-1H-Pyrazol-4-yl)Methyl)Piperazin-1-yl)Ethyl Acetate is Modulated by Serotonergic and GABAergic Pathways by Almeida, Lorena de Souza, Santana, Ianca Gontijo Cavalcante, da Silva Moreira, Lorrane Kelle, Turones, Larissa Córdova, Sanz, Germán, Vaz, Boniek G, de Carvalho, Flávio S, Lião, Luciano M, Menegatti, Ricardo, Costa, Elson Alves, de Brito, Adriane Ferreira

“…Pharmacological treatments for mental disorders, such as anxiety and depression, present several limitations and adverse effects. Therefore, new…”
Get more information

Antinociceptive, anti-inflammatory, and antioxidant effects of a flavonoid-rich phytocomplex from the leaves of Celtis iguanaea (jacq.) Sargent (Cannabaceae) by Almeida, Dionys de Souza, Honorato, Luiza Sousa, Moreira, Lorrane Kelle da Silva, Turones, Larissa Córdova, Bellard E Silva, Rúbia, Coimbra, Mairon Cesar, Pereira, Laura Jéssica, Pereira, Marx Osório Araújo, Fajemiroye, James Oluwagbamigbe, Paula, José Realino de, Melo, Júlio Onésio Ferreira, Martins, José Luis Rodrigues, Gil, Eric de Souza, Costa, Elson Alves, Couto, Renê Oliveira do

“…We demonstrated the antinociceptive and anti-inflammatory effects of the ethyl acetate leaf extract of (Jacq.) Sargent (EAECi) in mice. The antioxidant…”
Get full text

Anti-arthritic and Safety Pharmacological Effects of Gum Extract from Anacardium occidentale in Rats by da Silva, Daiany Priscilla Bueno, Florentino, Iziara Ferreira, da Silva Moreira, Lorrane Kelle, Cardoso, Carina Sofia, Fajemiroye, James Oluwagbamigbe, Ghedini, Paulo César, de Godoi, Murion Monteiro, dos Santos, Fernanda Cristina Alcântara, de Aleluia Batista, Karla, Pereira-Junior, Marcos Antônio, Fernandes, Kátia Flávia, Vaz, Boniek Gontijo, Ferreira, Marcella Rodrigues, Costa, Elson Alves

“…The antinociceptive and anti-inflammatory activities of a polysaccharide-free extract of the cashew gum obtained from Anacardium occidentale L., Anacardiaceae,…”
Get full text