Search Results - "Moreira, José Claudio Fonseca"

Systemic Inflammation Changes the Site of RAGE Expression from Endothelial Cells to Neurons in Different Brain Areas by Gasparotto, Juciano, Ribeiro, Camila Tiefensee, da Rosa-Silva, Helen Tais, Bortolin, Rafael Calixto, Rabelo, Thallita Kelly, Peixoto, Daniel Oppermann, Moreira, José Claudio Fonseca, Gelain, Daniel Pens

“…The receptor for advanced glycation endproducts (RAGE) is a transmembrane, immunoglobulin-like receptor that interacts with a broad repertoire of extracellular…”
Get full text

Targeted inhibition of RAGE in substantia nigra of rats blocks 6-OHDA–induced dopaminergic denervation by Gasparotto, Juciano, Ribeiro, Camila Tiefensee, Bortolin, Rafael Calixto, Somensi, Nauana, Rabelo, Thallita Kelly, Kunzler, Alice, Souza, Natália Cabral, Pasquali, Matheus Augusto de Bittencourt, Moreira, José Claudio Fonseca, Gelain, Daniel Pens

“…The receptor for advanced glycation endproducts (RAGE) is a pattern-recognition receptor associated with inflammation in most cell types. RAGE up-regulates the…”
Get full text

Excess of body weight is associated with accelerated T-cell senescence in hospitalized COVID-19 patients by Madruga, Mailton Prestes, Grun, Lucas Kich, Santos, Letícya Simone Melo Dos, Friedrich, Frederico Orlando, Antunes, Douglas Bitencourt, Rocha, Marcella Elesbão Fogaça, Silva, Pedro Luis, Dorneles, Gilson P, Teixeira, Paula Coelho, Oliveira, Tiago Franco, Romão, Pedro R T, Santos, Lucas, Moreira, José Claudio Fonseca, Michaelsen, Vinicius Schenk, Cypel, Marcelo, Antunes, Marcos Otávio Brum, Jones, Marcus Herbert, Barbé-Tuana, Florencia María, Bauer, Moisés Evandro

“…Several risk factors have been involved in the poor clinical progression of coronavirus disease-19 (COVID-19), including ageing, and obesity. SARS-CoV-2 may…”
Get full text

Vitamin A (retinol) up-regulates the receptor for advanced glycation endproducts (RAGE) through p38 and Akt oxidant-dependent activation by Gelain, Daniel Pens, de Bittencourt Pasquali, Matheus Augusto, Caregnato, Fernanda Freitas, Moreira, José Claudio Fonseca

“…Highlights ► Retinol increases RAGE immunocontent by an oxidant-dependent mechanism. ► P38 and Akt inhibition block the effect of retinol on RAGE. ► Retinol…”
Get full text

Antinociceptive action and redox properties of citronellal, an essential oil present in lemongrass by Quintans-Júnior, Lucindo, da Rocha, Ricardo Fagundes, Caregnato, Fernanda Freitas, Moreira, José Claudio Fonseca, da Silva, Francilene Amaral, Araújo, Adriano Antunes de Souza, dos Santos, João Paulo Almeida, Melo, Mônica Santos, de Sousa, Damião Pergentino, Bonjardim, Leonardo Rigoldi, Gelain, Daniel Pens

“…Citronellal (CT) is a monoterpenoid and the major constituent of the mixture of terpenoids that give the citronella oil its lemon scent. Citronella oil is…”
Get more information

Extracellular HSP70 Activates ERK1/2, NF-kB and Pro-Inflammatory Gene Transcription Through Binding with RAGE in A549 Human Lung Cancer Cells by Somensi, Nauana, Brum, Pedro Ozorio, de Miranda Ramos, Vitor, Gasparotto, Juciano, Zanotto-Filho, Alfeu, Rostirolla, Diana Carolina, da Silva Morrone, Maurilio, Moreira, José Claudio Fonseca, Pens Gelain, Daniel

“…Background/Aims: Heat shock protein 70 (HSP70) has been recently described with extracellular actions, where it is actively released in inflammatory…”
Get full text

Hecogenin acetate inhibits reactive oxygen species production and induces cell cycle arrest and senescence in the A549 human lung cancer cell line by Gasparotto, Juciano, Somensi, Nauana, Kunzler, Alice, Girardi, Carolina Saibro, de Bittencourt Pasquali, Matheus Augusto, Ramos, Vitor Miranda, Simoes-Pires, Andre, Quintans-Junior, Lucindo Jose, Branco, Alexsandro, Moreira, Jose Claudio Fonseca, Gelain, Daniel Pens

“…Cellular and molecular mechanisms related to lung cancer have been extensively studied in recent years, but the availability of effective treatments is still…”
Get more information

RAGE Against the Glycation Machine in Synucleinopathies: Time to Explore New Questions by Gelain, Daniel Pens, Bittencourt, Reykla Ramon, Bastos Mendes, Luiz Filipe, Moreira, José Claudio Fonseca, Outeiro, Tiago Fleming

“…Oligomerization and aggregation of misfolded forms of α-synuclein are believed to be key molecular mechanisms in Parkinson’s disease (PD) and other…”
Get full text

Comparison between proliferative and neuron-like SH-SY5Y cells as an in vitro model for Parkinson disease studies by Lopes, Fernanda Martins, Schröder, Rafael, Júnior, Mário Luiz Conte da Frota, Zanotto-Filho, Alfeu, Müller, Carolina Beatriz, Pires, André Simões, Meurer, Rosalva Thereza, Colpo, Gabriela Delevati, Gelain, Daniel Pens, Kapczinski, Flávio, Moreira, José Cláudio Fonseca, Fernandes, Marilda da Cruz, Klamt, Fabio

“…Abstract The molecular mechanisms underlying the cellular lost found in the nigrostriatal pathway during the progression of Parkinson's disease (PD) are not…”
Get full text

Inflammatory landscape of human brain tumors reveals an NFκB dependent cytokine pathway associated with mesenchymal glioblastoma by Zanotto-Filho, Alfeu, PhD, Gonçalves, Rosângela Mayer, Klafke, Karina, Oliveira de Souza, Priscila, Dillenburg, Fabiane Cristine, Carro, Luigi, Gelain, Daniel Pens, Fonseca Moreira, José Cláudio

“…Abstract The tumor microenvironment is being increasingly recognized as a key factor in cancer aggressiveness. In this study, we characterized the inflammatory…”
Get full text

Curcumin-loaded lipid-core nanocapsules as a strategy to improve pharmacological efficacy of curcumin in glioma treatment by Zanotto-Filho, Alfeu, Coradini, Karine, Braganhol, Elizandra, Schröder, Rafael, de Oliveira, Cláudia Melo, Simões-Pires, André, Battastini, Ana Maria Oliveira, Pohlmann, Adriana Raffin, Guterres, Sílvia Stanisçuaski, Forcelini, Cassiano Mateus, Beck, Ruy Carlos Ruver, Moreira, José Cláudio Fonseca

“…Curcumin-loaded lipid-core nanocapsules reduce tumor size in animal model of glioma. In this study, we developed curcumin-loaded lipid-core nanocapsules…”
Get full text

Animal model of autism induced by prenatal exposure to valproate: Behavioral changes and liver parameters by Bambini-Junior, Victorio, Rodrigues, Leticia, Behr, Guilherme Antônio, Moreira, José Cláudio Fonseca, Riesgo, Rudimar, Gottfried, Carmem

“…Abstract Autism is characterized by behavioral impairments in three main domains: social interaction; language, communication and imaginative play; and range…”
Get full text

The curry spice curcumin selectively inhibits cancer cells growth in vitro and in preclinical model of glioblastoma by Zanotto-Filho, Alfeu, Braganhol, Elizandra, Edelweiss, Maria Isabel, Behr, Guilherme A, Zanin, Rafael, Schröder, Rafael, Simões-Pires, André, Battastini, Ana Maria Oliveira, Moreira, José Cláudio Fonseca

“…Previous studies suggested that curcumin is a potential agent against glioblastomas (GBMs). However, the in vivo efficacy of curcumin in gliomas remains not…”
Get full text

Matrix Metalloproteinase-2 and Metalloproteinase-9 Activities are Associated with Blood–Brain Barrier Dysfunction in an Animal Model of Severe Sepsis by Dal-Pizzol, Felipe, Rojas, Hugo Alberto, dos Santos, Emilia Marcelina, Vuolo, Francieli, Constantino, Larissa, Feier, Gustavo, Pasquali, Matheus, Comim, Clarissa M., Petronilho, Fabrícia, Gelain, Daniel Pens, Quevedo, João, Moreira, José Cláudio Fonseca, Ritter, Cristiane

“…There is no description on the mechanisms associated with blood–brain barrier (BBB) disruption during sepsis development. Thus, we here determined changes in…”
Get full text

Incidence of lung cancer and mortality among civil construction industry workers: A protocol for a systematic review and meta-analysis by Cahuana Pinto, Rita Stella Maria, Castro Panzenhagen, Alana, Silva Oliveira, Luis Felipe, Fonseca Moreira, José Claudio, Schnorr, Carlos Eduardo

“…The construction sector is one of the most stable growth industries in the world. However, many studies have suggested an association between occupational…”
Get full text

Developmental neurotoxicity of the hippocampus following in utero exposure to methylmercury: impairment in cell signaling by Heimfarth, Luana, Delgado, Jeferson, Mignori, Moara Rodrigues, Gelain, Daniel Pens, Moreira, José Cláudio Fonseca, Pessoa-Pureur, Regina

“…In this study, we assessed some hippocampal signaling cascades and behavioral impairments in 30-day-old rat pups prenatally exposed to methylmercury (MeHg)…”
Get full text

Zinc Supplementation Partially Decreases the Harmful Effects of a Cafeteria Diet in Rats but Does Not Prevent Intestinal Dysbiosis by Squizani, Samia, Jantsch, Jeferson, Rodrigues, Fernanda da Silva, Braga, Matheus Filipe, Eller, Sarah, de Oliveira, Tiago Franco, Silveira, Alexandre Kleber, Moreira, José Cláudio Fonseca, Giovenardi, Marcia, Porawski, Marilene, Guedes, Renata Padilha

“…Zinc (Zn) plays an important role in metabolic homeostasis and may modulate neurological impairment related to obesity. The present study aimed to evaluate the…”
Get full text

Differential macrophage activation alters the expression profile of NTPDase and ecto-5'-nucleotidase by Zanin, Rafael Fernandes, Braganhol, Elizandra, Bergamin, Letícia Scussel, Campesato, Luís Felipe Ingrassia, Filho, Alfeu Zanotto, Moreira, José Cláudio Fonseca, Morrone, Fernanda Bueno, Sévigny, Jean, Schetinger, Maria Rosa Chitolina, de Souza Wyse, Angela Terezinha, Battastini, Ana Maria Oliveira

“…Macrophages are key elements in the inflammatory process, whereas depending on the micro-environmental stimulation they exhibit a pro-inflammatory…”
Get full text

Anti-RAGE antibody selectively blocks acute systemic inflammatory responses to LPS in serum, liver, CSF and striatum by Gasparotto, Juciano, Tiefensee Ribeiro, Camila, Calixto Bortolin, Rafael, Schaan Fernandes, Henrique, Alves Teixeira, Alexsander, Otavio Rodrigues Guasselli, Marcelo, Aziz Jose O. Agani, Crepin, Cabral Souza, Natália, Grings, Mateus, Leipnitz, Guilhian, Mautone Gomes, Henrique, Augusto de Bittencourt Pasquali, Matheus, Dunkley, Peter R, Dickson, Phillip W, Claudio Fonseca Moreira, José, Pens Gelain, Daniel

“…Highlights • Systemic LPS differently affects CSF, cortex, VTA and striatum within 24h. • Systemic RAGE-Ab administration inhibits liver, serum, CSF and…”
Get full text

Proteasome inhibitor MG132 induces selective apoptosis in glioblastoma cells through inhibition of PI3K/Akt and NFkappaB pathways, mitochondrial dysfunction, and activation of p38-JNK1/2 signaling by Zanotto-Filho, Alfeu, Braganhol, Elizandra, Battastini, Ana Maria Oliveira, Moreira, José Cláudio Fonseca

“…Summary Proteasome inhibitors are emerging as a new class of anticancer agents. In this work, we examined the mechanisms underlying cytotoxicity, selectivity…”
Get full text