Sexual function and metabolic/hormonal changes in women using long-term hormonal and non-hormonal contraceptives: a pilot study

Female sexual dysfunction is a common condition that negatively impacts the emotional health and quality of life of the affected individuals. Long-acting reversible contraceptives (LARCs) are becoming increasingly popular due to their effectiveness and convenience. LARCs can be hormonal (etonogestre...

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Bibliographic Details
Published in:	BMC women's health Vol. 20; no. 1; pp. 240 - 11
Main Authors:	Moreira, Igor Fernando de Aquino, Bianchini, Maria Passos, Moreira, Gabrielle Rodrigues Campos, Almeida, Alessandra Maciel, Rezende, Bruno Almeida
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 27-10-2020 BioMed Central BMC
Subjects:	Birth control Body Composition - drug effects Brazil Cancer Comparative analysis Complications and side effects Contraceptive Agents, Female - adverse effects Contraceptive Agents, Female - therapeutic use Contraceptives Development and progression Female Female sexual dysfunction Female sexual function index Gynecological research Gynecology Hospitals Humans Levonorgestrel - adverse effects Levonorgestrel - therapeutic use Long-acting reversible contraception Medical screening Metabolism Methods Motility Orgasm Pilot Projects Pregnancy Prospective Studies Quality of Life Questionnaires Reproductive health Risk factors Sexual Behavior - drug effects Sexual disorders Sexual Dysfunction, Physiological - chemically induced Sexual health Sexuality Subdermal implant Uterus Womens health Brazil United States > US Female sexual dysfunction Female sexual function index Subdermal implant Long-acting reversible contraception Sexuality
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Summary:	Female sexual dysfunction is a common condition that negatively impacts the emotional health and quality of life of the affected individuals. Long-acting reversible contraceptives (LARCs) are becoming increasingly popular due to their effectiveness and convenience. LARCs can be hormonal (etonogestrel releasing implant-ENG and Levonorgestrel intrauterine system-LNG) or non-hormonal (copper intrauterine device-CuIUD and copper-silver intrauterine device-SIUD). There are very few studies that assess the influence on LARCS on sexual function are lacking. This study aimed to assess changes in sexual function as well as metabolic and hormonal parameters in women after implantation with LARCs. In this prospective cohort study, we assessed 80 women who visited the Military Police Hospital in Brazil for LARCs placement. The study participants were divided into 4 groups according to the type of LARC received: ENG n = 17; LNG n = 22, CuIUD n = 18 and SIUD n = 23. The four groups were evaluated twice (prior to LARC placement and approximately 3 months later) for sexual function, using the Female Sexual Function Index (FSFI) and Female Sexual Quotient (QS-F) questionnaires. Metabolic and hormonal parameters were also assessed using blood tests. ENG worsened sexual function according to FSFI and QS-F, across all domains. A decrease in sex hormone-binding globulin (SHBG) between stages was observed for all groups. We observed an improvement in sexual function for non-hormonal LARCs, specially SIUD. However this improvement was not statistically significant. The use of non-hormonal LARCS improved sexual function. Etonogestrel implants, had a negative influence on sexual function, probably by blocking ovarian function, and thus reducing the production of androgens and estrogens.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1472-6874 1472-6874
DOI:	10.1186/s12905-020-01107-1