Search Results - "Moreira, Fonseca"

Comparison between proliferative and neuron-like SH-SY5Y cells as an in vitro model for Parkinson disease studies by Lopes, Fernanda Martins, Schröder, Rafael, Júnior, Mário Luiz Conte da Frota, Zanotto-Filho, Alfeu, Müller, Carolina Beatriz, Pires, André Simões, Meurer, Rosalva Thereza, Colpo, Gabriela Delevati, Gelain, Daniel Pens, Kapczinski, Flávio, Moreira, José Cláudio Fonseca, Fernandes, Marilda da Cruz, Klamt, Fabio

“…Abstract The molecular mechanisms underlying the cellular lost found in the nigrostriatal pathway during the progression of Parkinson's disease (PD) are not…”
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Differential macrophage activation alters the expression profile of NTPDase and ecto-5'-nucleotidase by Zanin, Rafael Fernandes, Braganhol, Elizandra, Bergamin, Letícia Scussel, Campesato, Luís Felipe Ingrassia, Filho, Alfeu Zanotto, Moreira, José Cláudio Fonseca, Morrone, Fernanda Bueno, Sévigny, Jean, Schetinger, Maria Rosa Chitolina, de Souza Wyse, Angela Terezinha, Battastini, Ana Maria Oliveira

“…Macrophages are key elements in the inflammatory process, whereas depending on the micro-environmental stimulation they exhibit a pro-inflammatory…”
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The curry spice curcumin selectively inhibits cancer cells growth in vitro and in preclinical model of glioblastoma by Zanotto-Filho, Alfeu, Braganhol, Elizandra, Edelweiss, Maria Isabel, Behr, Guilherme A, Zanin, Rafael, Schröder, Rafael, Simões-Pires, André, Battastini, Ana Maria Oliveira, Moreira, José Cláudio Fonseca

“…Previous studies suggested that curcumin is a potential agent against glioblastomas (GBMs). However, the in vivo efficacy of curcumin in gliomas remains not…”
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Obesity associated with coal ash inhalation triggers systemic inflammation and oxidative damage in the hippocampus of rats by Gasparotto, Juciano, Chaves, Paloma Rodrigues, da Boit Martinello, Katia, Silva Oliveira, Luis Felipe, Gelain, Daniel Pens, Fonseca Moreira, José Claudio

“…People with large amounts of adipose tissue are more vulnerable and more likely to develop diseases where oxidative stress and inflammation play a pivotal…”
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Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas by Zanotto-Filho, Alfeu, Braganhol, Elizandra, Klafke, Karina, Figueiró, Fabrício, Terra, Sílvia Resende, Paludo, Francis Jackson, Morrone, Maurílio, Bristot, Ivi Juliana, Battastini, Ana Maria, Forcelini, Cassiano Mateus, Bishop, Alexander James Roy, Gelain, Daniel Pens, Moreira, José Cláudio Fonseca

“…Abstract Glioblastoma is a devastating primary brain tumor resistant to conventional therapies. In this study, we tested the efficacy of combining temozolomide…”
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Inflammatory landscape of human brain tumors reveals an NFκB dependent cytokine pathway associated with mesenchymal glioblastoma by Zanotto-Filho, Alfeu, PhD, Gonçalves, Rosângela Mayer, Klafke, Karina, Oliveira de Souza, Priscila, Dillenburg, Fabiane Cristine, Carro, Luigi, Gelain, Daniel Pens, Fonseca Moreira, José Cláudio

“…Abstract The tumor microenvironment is being increasingly recognized as a key factor in cancer aggressiveness. In this study, we characterized the inflammatory…”
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Industry payments to family medicine residents in Portugal: a descriptive analysis of the national transparency database by Ruivo, Marta, Cossutta, Fabrizio, Moreira Fonseca, Nuno

“…ObjectiveTo analyse payments made to family medicine residents by the pharmaceutical industry during their residency in Portugal, using mandatory disclosure…”
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Is it all the RAGE? Defining the role of the receptor for advanced glycation end products in Parkinson's disease by Gasparotto, Juciano, Somensi, Nauana, Girardi, Carolina Saibro, Bittencourt, Reykla Ramon, Oliveira, Laura Martinewski, Hoefel, Laura Piloneto, Scheibel, Ingrid Matsubara, Peixoto, Daniel Oppermann, Moreira, José Claudio Fonseca, Outeiro, Tiago Fleming, Gelain, Daniel Pens

“…The receptor for advanced glycation end products (RAGE) is a transmembrane receptor that belongs to the immunoglobulin superfamily and is extensively…”
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Systemic Inflammation Changes the Site of RAGE Expression from Endothelial Cells to Neurons in Different Brain Areas by Gasparotto, Juciano, Ribeiro, Camila Tiefensee, da Rosa-Silva, Helen Tais, Bortolin, Rafael Calixto, Rabelo, Thallita Kelly, Peixoto, Daniel Oppermann, Moreira, José Claudio Fonseca, Gelain, Daniel Pens

“…The receptor for advanced glycation endproducts (RAGE) is a transmembrane, immunoglobulin-like receptor that interacts with a broad repertoire of extracellular…”
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Incidence of lung cancer and mortality among civil construction industry workers: A protocol for a systematic review and meta-analysis by Cahuana Pinto, Rita Stella Maria, Castro Panzenhagen, Alana, Silva Oliveira, Luis Felipe, Fonseca Moreira, José Claudio, Schnorr, Carlos Eduardo

“…The construction sector is one of the most stable growth industries in the world. However, many studies have suggested an association between occupational…”
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Curcumin-loaded lipid-core nanocapsules as a strategy to improve pharmacological efficacy of curcumin in glioma treatment by Zanotto-Filho, Alfeu, Coradini, Karine, Braganhol, Elizandra, Schröder, Rafael, de Oliveira, Cláudia Melo, Simões-Pires, André, Battastini, Ana Maria Oliveira, Pohlmann, Adriana Raffin, Guterres, Sílvia Stanisçuaski, Forcelini, Cassiano Mateus, Beck, Ruy Carlos Ruver, Moreira, José Cláudio Fonseca

“…Curcumin-loaded lipid-core nanocapsules reduce tumor size in animal model of glioma. In this study, we developed curcumin-loaded lipid-core nanocapsules…”
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Effects of coconut oil long-term supplementation in Wistar rats during metabolic syndrome - regulation of metabolic conditions involving glucose homeostasis, inflammatory signals, and oxidative stress by Mautone Gomes, Henrique, Silveira, Alexandre K., Gasparotto, Juciano, Bortolin, Rafael Calixto, Terra, Silvia R., Brum, Pedro O., Gelain, Daniel P., Fonseca Moreira, José C.

“…This study was designed to evaluate the long-term effects of Fructose (20%) feeding in rats, simulating metabolic syndrome (MetS), and the effects of coconut…”
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DHA/EPA supplementation decreases anxiety-like behaviour, but it does not ameliorate metabolic profile in obese male rats by Neto, João, Jantsch, Jeferson, de Oliveira, Simone, Braga, Matheus Filipe, Castro, Luís Felipe dos Santos, Diniz, Bruna Ferrary, Moreira, José Claudio Fonseca, Giovenardi, Marcia, Porawski, Marilene, Guedes, Renata Padilha

“…Obesity is a major public health problem that predisposes to several diseases and higher mortality in patients with COVID-19. Obesity also generates…”
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Targeted inhibition of RAGE in substantia nigra of rats blocks 6-OHDA–induced dopaminergic denervation by Gasparotto, Juciano, Ribeiro, Camila Tiefensee, Bortolin, Rafael Calixto, Somensi, Nauana, Rabelo, Thallita Kelly, Kunzler, Alice, Souza, Natália Cabral, Pasquali, Matheus Augusto de Bittencourt, Moreira, José Claudio Fonseca, Gelain, Daniel Pens

“…The receptor for advanced glycation endproducts (RAGE) is a pattern-recognition receptor associated with inflammation in most cell types. RAGE up-regulates the…”
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Developmental neurotoxicity of the hippocampus following in utero exposure to methylmercury: impairment in cell signaling by Heimfarth, Luana, Delgado, Jeferson, Mignori, Moara Rodrigues, Gelain, Daniel Pens, Moreira, José Cláudio Fonseca, Pessoa-Pureur, Regina

“…In this study, we assessed some hippocampal signaling cascades and behavioral impairments in 30-day-old rat pups prenatally exposed to methylmercury (MeHg)…”
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Animal model of autism induced by prenatal exposure to valproate: Behavioral changes and liver parameters by Bambini-Junior, Victorio, Rodrigues, Leticia, Behr, Guilherme Antônio, Moreira, José Cláudio Fonseca, Riesgo, Rudimar, Gottfried, Carmem

“…Abstract Autism is characterized by behavioral impairments in three main domains: social interaction; language, communication and imaginative play; and range…”
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The glial perspective of autism spectrum disorders by Zeidán-Chuliá, Fares, Salmina, Alla B, Malinovskaya, Natalia A, Noda, Mami, Verkhratsky, Alexei, Moreira, José Cláudio Fonseca

“…The aetiology of autism spectrum disorders remains unclear although a growing number of associated genetic abnormalities and environmental factors have been…”
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Proteasome inhibitor MG132 induces selective apoptosis in glioblastoma cells through inhibition of PI3K/Akt and NFkappaB pathways, mitochondrial dysfunction, and activation of p38-JNK1/2 signaling by Zanotto-Filho, Alfeu, Braganhol, Elizandra, Battastini, Ana Maria Oliveira, Moreira, José Cláudio Fonseca

“…Summary Proteasome inhibitors are emerging as a new class of anticancer agents. In this work, we examined the mechanisms underlying cytotoxicity, selectivity…”
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Characterization and modulation of microglial phenotypes in an animal model of severe sepsis by Michels, Monique, Abatti, Mariane Rocha, Ávila, Pricila, Vieira, Andriele, Borges, Heloisa, Carvalho Junior, Celso, Wendhausen, Diogo, Gasparotto, Juciano, Tiefensee Ribeiro, Camila, Moreira, José Claudio Fonseca, Gelain, Daniel Pens, Dal‐Pizzol, Felipe

“…We aim to characterize the kinetics of early and late microglial phenotypes after systemic inflammation in an animal model of severe sepsis and the effects of…”
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Chronic ozone exposure alters the secondary metabolite profile, antioxidant potential, anti-inflammatory property, and quality of red pepper fruit from Capsicum baccatum by Bortolin, Rafael Calixto, Caregnato, Fernanda Freitas, Divan Junior, Armando Molina, Zanotto-Filho, Alfeu, Moresco, Karla Suzana, de Oliveira Rios, Alessandro, de Oliveira Salvi, Aguisson, Ortmann, Caroline Flach, de Carvalho, Pâmela, Reginatto, Flávio Henrique, Gelain, Daniel Pens, Fonseca Moreira, José Cláudio

“…Tropospheric ozone (O3) background concentrations have increased since pre-industrial times, reaching phytotoxic concentrations in many regions globally…”
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