Search Results - "Moreira, Dayson"

Myeloid cell–targeted miR-146a mimic inhibits NF-κB–driven inflammation and leukemia progression in vivo by Su, Yu-Lin, Wang, Xiuli, Mann, Mati, Adamus, Tomasz P., Wang, Dongfang, Moreira, Dayson F., Zhang, Zhuoran, Ouyang, Ching, He, Xin, Zhang, Bin, Swiderski, Piotr M., Forman, Stephen J., Baltimore, David, Li, Ling, Marcucci, Guido, Boldin, Mark P., Kortylewski, Marcin

“…NF-κB is a key regulator of inflammation and cancer progression, with an important role in leukemogenesis. Despite its therapeutic potential, targeting NF-κB…”
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Large, Anionic Liposomes Enable Targeted Intraperitoneal Delivery of a TLR 7/8 Agonist To Repolarize Ovarian Tumors’ Microenvironment by Kang, Yanan, Flores, Linda, Ngai, Hoi Wa, Cornejo, Yvonne R, Haber, Tom, McDonald, Marisa, Moreira, Dayson Friaça, Gonzaga, Joanna Marie, Abidi, Wafa, Zhang, Yijia, Hammad, Mohamed, Kortylewski, Marcin, Aboody, Karen S, Berlin, Jacob M

“…Ovarian cancer is the most lethal gynecological malignancy in the United States. Current standard of treatment includes surgical debulking and chemotherapy,…”
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TLR9-Targeted STAT3 Silencing Abrogates Immunosuppressive Activity of Myeloid-Derived Suppressor Cells from Prostate Cancer Patients by Hossain, Dewan M S, Pal, Sumanta K, Moreira, Dayson, Duttagupta, Priyanka, Zhang, Qifang, Won, Haejung, Jones, Jeremy, D'Apuzzo, Massimo, Forman, Stephen, Kortylewski, Marcin

“…Recent advances in immunotherapy of advanced human cancers underscored the need to address and eliminate tumor immune evasion. The myeloid-derived suppressor…”
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TLR9 expression and secretion of LIF by prostate cancer cells stimulates accumulation and activity of polymorphonuclear MDSCs by Won, Haejung, Moreira, Dayson, Gao, Chan, Duttagupta, Priyanka, Zhao, Xingli, Manuel, Edwin, Diamond, Don, Yuan, Yate‐Ching, Liu, Zheng, Jones, Jeremy, D’Apuzzo, Massimo, Pal, Sumanta, Kortylewski, Marcin

“…TLR9 upregulation in prostate cancer cells results in the LIF‐mediated recruitment and increased tolerogenic activity of polymorphonuclear myeloid‐derived…”
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Cell Death-Associated Molecular-Pattern Molecules: Inflammatory Signaling and Control by Sangiuliano, Beatriz, Pérez, Nancy Marcela, Moreira, Dayson F., Belizário, José E.

“…Apoptosis, necroptosis, and pyroptosis are different cellular death programs characterized in organs and tissues as consequence of microbes infection, cell…”
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Reduced T-cell Numbers and Elevated Levels of Immunomodulatory Cytokines in Metastatic Prostate Cancer Patients De Novo Resistant to Abiraterone and/or Enzalutamide Therapy by Pal, Sumanta K, Moreira, Dayson, Won, Haejung, White, Seok Woon, Duttagupta, Pryanka, Lucia, Marc, Jones, Jeremy, Hsu, JoAnn, Kortylewski, Marcin

“…Currently, there are two Food and Drug Administration (FDA)-approved drugs for androgen deprivation therapy (ADT) of metastatic castration-resistant prostate…”
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Bortezomib (PS-341) treatment decreases inflammation and partially rescues the expression of the dystrophin-glycoprotein complex in GRMD dogs by Araujo, Karla P C, Bonuccelli, Gloria, Duarte, Caio N, Gaiad, Thais P, Moreira, Dayson F, Feder, David, Belizario, José E, Miglino, Maria A, Lisanti, Michael P, Ambrosio, Carlos E

“…Golden retriever muscular dystrophy (GRMD) is a genetic myopathy corresponding to Duchenne muscular dystrophy (DMD) in humans. Muscle atrophy is known to be…”
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Leukemia cell–targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity by Hossain, Dewan Md Sakib, Dos Santos, Cedric, Zhang, Qifang, Kozlowska, Anna, Liu, Hongjun, Gao, Chan, Moreira, Dayson, Swiderski, Piotr, Jozwiak, Agnieszka, Kline, Justin, Forman, Stephen, Bhatia, Ravi, Kuo, Ya-Huei, Kortylewski, Marcin

“…Signal transducer and activator of transcription 3 (STAT3) is an oncogene and immune checkpoint commonly activated in cancer cells and in tumor-associated…”
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Targeting STAT3 in tumor-associated antigen-presenting cells as a strategy for kidney and bladder cancer immunotherapy by Alcantara, Marice B, Tang, Wilson S, Wang, Dongfang, Kaniowski, Damian, Kang, Elaine, Dizman, Nazli, Chehrazi-Raffle, Alexander, Meza, Luis, Zengin, Zeynep, Hall, Jeremy, Hsu, JoAnn, Egelston, Colt, Moreira, Dayson, Horsager, Alan, Pal, Sumanta K, Kortylewski, Marcin

“…Immune checkpoint blockade (ICB) improved clinical outcomes in renal and bladder cancer patients, but the response rates remain limited especially in…”
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Using Pharmacogenomic Databases for Discovering Patient-Target Genes and Small Molecule Candidates to Cancer Therapy by Belizário, José E, Sangiuliano, Beatriz A, Perez-Sosa, Marcela, Neyra, Jennifer M, Moreira, Dayson F

“…With multiple omics strategies being applied to several cancer genomics projects, researchers have the opportunity to develop a rational planning of targeted…”
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Dermcidin exerts its oncogenic effects in breast cancer via modulation of ERBB signaling by Bancovik, Jasna, Moreira, Dayson F, Carrasco, Daniel, Yao, Jun, Porter, Dale, Moura, Ricardo, Camargo, Anamaria, Fontes-Oliveira, Cibely C, Malpartida, Miguel G, Carambula, Silvia, Vannier, Edouard, Strauss, Bryan E, Wakamatsu, Alda, Alves, Venancio Af, Logullo, Angela F, Soares, Fernando A, Polyak, Kornelia, Belizário, José E

“…We previously identified dermicidin (DCD), which encodes a growth and survival factor, as a gene amplified and overexpressed in a subset of breast tumors…”
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Automated in Vivo Assessment of Vascular Response to Radiation Using a Hybrid Theranostic X-Ray Irradiator/Fluorescence Molecular Imaging System by Nouizi, Farouk, Brooks, Jamison, Zuro, Darren M., Madabushi, Srideshikan Sargur, Moreira, Dayson, Kortylewski, Marcin, Froelich, Jerry, Su, Lydia M., Gulsen, Gultekin, Hui, Susanta K.

“…Hypofractionated stereotactic body radiotherapy treatments (SBRT) have demonstrated impressive results for the treatment of a variety of solid tumors. The role…”
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541 Investigating myeloid derived suppressor cells (MDSCs) and oligonucleotide based targeting of STAT3 in renal cell carcinoma by Alcantara, Marice, Moreira, Dayson, Hung, Chia-Yang, Wang, Dongfang, Hsu, JoAnn, Pal, Sumanta, Kortylewski, Marcin

“…BackgroundRecent advancements in the treatment of renal cell carcinoma (RCC) using immune checkpoint inhibitors (ICI) against PD1 or CTLA-4 receptors have…”
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Myeloid cells as a target for oligonucleotide therapeutics: turning obstacles into opportunities by Kortylewski, Marcin, Moreira, Dayson

“…Immunotherapies emerged as an alternative for cancer treatment, yet their clinical efficacies are still limited, especially in case of solid tumors. Myeloid…”
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Role of SOCS-1 Gene on Melanoma Cell Growth and Tumor Development by Scutti, Jorge A. Borin, Matsuo, Alisson Leonardo, Pereira, Felipe Valença, Massaoka, Mariana Hiromi, Figueiredo, Carlos Rogério, Moreira, Dayson Friaça, Belizário, José Ernesto, Travassos, Luiz R

“…Melanoma is the most aggressive form of skin cancer, and its incidence has increased dramatically over the years. The murine B16F10 melanoma in syngeneic…”
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Identification of a metallopeptidase with TOP-like activity in Paracoccidioides brasiliensis, with increased expression in a virulent strain by Gravi, Ellen T., Paschoalin, Thaysa, Dias, Bianca R., Moreira, Dayson F., Belizario, José E., Oliveira, Vitor, Carmona, Adriana K., Juliano, Maria A., Travassos, Luiz R., Rodrigues, Elaine G.

“…Paracoccidioidomycosis (PCM), caused by the pathogenic fungus Paracoccidioides brasiliensis, is a systemic mycosis with severe acute and chronic forms. The…”
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Myeloid cell-targeted STAT3 inhibition sensitizes head and neck cancers to radiotherapy and T cell-mediated immunity by Moreira, Dayson, Sampath, Sagus, Won, Haejung, White, Seok Voon, Su, Yu-Lin, Alcantara, Marice, Wang, Chongkai, Lee, Peter, Maghami, Ellie, Massarelli, Erminia, Kortylewski, Marcin

“…The tumor microenvironment affects the outcome of radiotherapy against head and neck squamous cell carcinoma (HNSCC). We recently found that tolerogenic…”
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STAT3 Inhibition Combined with CpG Immunostimulation Activates Antitumor Immunity to Eradicate Genetically Distinct Castration-Resistant Prostate Cancers by Moreira, Dayson, Adamus, Tomasz, Zhao, Xingli, Su, Yu-Lin, Zhang, Zhuoran, White, Seok Voon, Swiderski, Piotr, Lu, Xin, DePinho, Ronald A, Pal, Sumanta K, Kortylewski, Marcin

“…Prostate cancers show remarkable resistance to emerging immunotherapies, partly due to tolerogenic STAT3 signaling in tumor-associated myeloid cells. Here, we…”
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Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia by Zhang, Qifang, Hossain, Dewan Md Sakib, Duttagupta, Priyanka, Moreira, Dayson, Zhao, Xingli, Won, Haejung, Buettner, Ralf, Nechaev, Sergey, Majka, Marcin, Zhang, Bin, Cai, Qi, Swiderski, Piotr, Kuo, Ya-Huei, Forman, Stephen, Marcucci, Guido, Kortylewski, Marcin

“…Targeting oncogenic transcription factor signal transducer and activator of transcription 3 (STAT3) in acute myeloid leukemia (AML) can reduce blast survival…”
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Abstract 5356: Targeted in vivo delivery of NF-κB decoy oligodeoxynucleotide augments efficacy of radiation therapy against B-cell lymphomas by zhang, Zhuoran, Zhao, Xingli, Moreira, Dayson, Su, Yu-Lin, Swiderski, Piotr, Forman, Stephen, Kwak, Larry, Kortylewski, Marcin

“…Abstract Despite recent advances in the treatment of non-Hodgkin B-cell lymphoma (BCL), significant numbers of patients relapse or remain refractory to current…”
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