Search Results - "Moree, Ben"

In vitro centromere and kinetochore assembly on defined chromatin templates by Guse, Annika, Carroll, Christopher W., Moree, Ben, Fuller, Colin J., Straight, Aaron F.

“…In vitro reconstitution of the centromere Centromeres are specialized chromatin domains that are essential for chromosome segregation and cell division, but it…”
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CENP-C recruits M18BP1 to centromeres to promote CENP-A chromatin assembly by Moree, Ben, Meyer, Corey B, Fuller, Colin J, Straight, Aaron F

“…Eukaryotic chromosomes segregate by attaching to microtubules of the mitotic spindle through a chromosomal microtubule binding site called the kinetochore…”
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Dissection of CENP-C-directed centromere and kinetochore assembly by Milks, Kirstin J, Moree, Ben, Straight, Aaron F

“…Eukaryotic cells ensure accurate chromosome segregation in mitosis by assembling a microtubule-binding site on each chromosome called the kinetochore that…”
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ATP-Competitive MLKL Binders Have No Functional Impact on Necroptosis by Ma, Bin, Marcotte, Doug, Paramasivam, Murugan, Michelsen, Klaus, Wang, Ti, Bertolotti-Ciarlet, Andrea, Jones, John Howard, Moree, Ben, Butko, Margaret, Salafsky, Joshua, Sun, Xin, McKee, Timothy, Silvian, Laura F

“…MLKL is a pore forming pseudokinase involved in the final stage of necroptosis, a form of programmed cell death. Its phosphorylation by RIPK3 is necessary for…”
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Spindle Checkpoint Protein Dynamics at Kinetochores in Living Cells by Howell, Bonnie J, Moree, Ben, Farrar, Emily M, Stewart, Scott, Fang, Guowei, Salmon, E.D

“…Background: To test current models for how unattached and untense kinetochores prevent Cdc20 activation of the anaphase-promoting complex/cyclosome (APC/C)…”
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Merotelic kinetochore orientation occurs frequently during early mitosis in mammalian tissue cells and error correction is achieved by two different mechanisms by Cimini, Daniela, Moree, Ben, Canman, Julie C, Salmon, E D

“…Merotelic kinetochore orientation is an error that occurs when a single kinetochore becomes attached to microtubules from two spindle poles rather than just to…”
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hNuf2 Inhibition Blocks Stable Kinetochore-Microtubule Attachment and Induces Mitotic Cell Death in HeLa Cells by DeLuca, Jennifer G., Moree, Ben, Hickey, Jennifer M., Kilmartin, John V., Salmon, E. D.

“…Identification of proteins that couple kinetochores to spindle microtubules is critical for understanding how accurate chromosome segregation is achieved in…”
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Taxol-stabilized microtubules can position the cytokinetic furrow in mammalian cells by Shannon, Katie B, Canman, Julie C, Ben Moree, C, Tirnauer, Jennifer S, Salmon, E D

“…How microtubules act to position the plane of cell division during cytokinesis is a topic of much debate. Recently, we showed that a subpopulation of stable…”
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Spinning disk confocal microscope system for rapid high-resolution, multimode, fluorescence speckle microscopy and green fluorescent protein imaging in living cells by Maddox, Paul S, Moree, Ben, Canman, Julie C, Salmon, E D

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Angular Mapping of Protein Structure Using Nonlinear Optical Measurements by Clancy, Bason, Moree, Ben, Salafsky, Joshua

“…Proteins are inherently dynamic, flexible molecules that execute precise conformational changes to perform their functions, but existing techniques to directly…”
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Characterization of Protein Structural Changes using a Novel Nonlinear Optical Technique by Clancy, Bason, Moree, Ben, Salafsky, Joshua

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Detection of Ligand-Induced Conformational Changes in Oligonucleotides by Second-Harmonic Generation at a Supported Lipid Bilayer Interface by Butko, Margaret T, Moree, Ben, Mortensen, Richard B, Salafsky, Joshua

“…There is a high demand for characterizing oligonucleotide structural changes associated with binding interactions as well as identifying novel binders that…”
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Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells by Moree, Ben, Yin, Guowei, Lázaro, Diana F., Munari, Francesca, Strohäker, Timo, Giller, Karin, Becker, Stefan, Outeiro, Tiago F., Zweckstetter, Markus, Salafsky, Joshua

“…Proteins are structurally dynamic molecules that perform specialized functions through unique conformational changes accessible in physiological environments…”
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Evaluating the Contribution of Transition-State Destabilization to Changes in the Residence Time of Triazole-Based InhA Inhibitors by Spagnuolo, Lauren A, Eltschkner, Sandra, Yu, Weixuan, Daryaee, Fereidoon, Davoodi, Shabnam, Knudson, Susan E, Allen, Eleanor K. H, Merino, Jonathan, Pschibul, Annica, Moree, Ben, Thivalapill, Neil, Truglio, James J, Salafsky, Joshua, Slayden, Richard A, Kisker, Caroline, Tonge, Peter J

“…A critical goal of lead compound selection and optimization is to maximize target engagement while minimizing off-target binding. Since target engagement is a…”
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Second harmonic generation detection of Ras conformational changes and discovery of a small molecule binder by Donohue, Elizabeth, Khorsand, Sina, Mercado, Gabriel, Varney, Kristen M., Wilder, Paul T., Yu, Wenbo, MacKerell, Alexander D., Alexander, Patrick, Van, Que N., Moree, Ben, Stephen, Andrew G., Weber, David J., Salafsky, Joshua, McCormick, Frank

“…Second harmonic generation (SHG) is an emergent biophysical method that sensitively measures real-time conformational change of biomolecules in the presence of…”
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Protein Conformational Changes Are Detected and Resolved Site Specifically by Second-Harmonic Generation by Moree, Ben, Connell, Katelyn, Mortensen, Richard B., Liu, C. Tony, Benkovic, Stephen J., Salafsky, Joshua

“…We present here a straightforward, broadly applicable technique for real-time detection and measurement of protein conformational changes in solution. This…”
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Abstract 4018: Identifying allosteric modulators of KRas using second harmonic generation by Vo, Elizabeth Donohue, Mercado, Gabriel Besserer, Alexander, Patrick, Moree, Ben, Van, Que, Stephen, Andrew G., Salafsky, Joshua, McCormick, Frank

“…The Ras protein family consists of small GTPases that are critical signaling transducers regulating cellular processes including proliferation,…”
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Biologies Quality Control: The Growing Need for Accessible Proteomics by Moree, Ben

“…An accurate understanding, down to each amino acid and small variation, is key to the discovery and development process, requiring broad access to…”
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Biologies Quality Control: The Growing Need for Accessible Proteomics by Moree, Ben

“…Having confidence that the biologic drug is being made consistently with low batch variation may allow more confidence and insight in the interpretation of…”
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Biologics Quality Control: The Growing Need for Accessible Proteomics: There is a great need for sensitive, precise, and easily accessible analytical detection techniques for protein sequencing by Moree, Ben

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