Search Results - "Moreau, Alain"
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Reappraisal of metformin efficacy in the treatment of type 2 diabetes: a meta-analysis of randomised controlled trials
Published in PLoS medicine (01-04-2012)“…The UK Prospective Diabetes Study showed that metformin decreases mortality compared to diet alone in overweight patients with type 2 diabetes mellitus. Since…”
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Abilities and limitations of thermal mass activation for thermal comfort, peak shifting and shaving: A review
Published in Building and environment (01-06-2017)“…The building and infrastructure sector is accountable for 40% of the total worldwide energy consumption and one third of the worldwide GHG emissions. In…”
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Heteroleptic Dirhodium(II) Complexes with Redox‐Active Ferrocenyl Ligands: Synthesis, Electrochemical Properties, and Redox‐Responsive Chemoselectivity in Carbene C−H Insertion
Published in European journal of inorganic chemistry (27-04-2022)“…A series of original heteroleptic dirhodium(II) complexes (4 a–j) of formula [Rh2(OAc)3(L)], where L is a redox‐active ferrocenecarboxylate ligand, has been…”
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Altered mechanotransduction in adolescent idiopathic scoliosis osteoblasts: an exploratory in vitro study
Published in Scientific reports (03-02-2022)“…Adolescent idiopathic scoliosis (AIS) is the most prevalent pediatric spinal deformity. We previously demonstrated elongated cilia and an altered molecular…”
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Circulating microRNA expression signatures accurately discriminate myalgic encephalomyelitis from fibromyalgia and comorbid conditions
Published in Scientific reports (02-02-2023)“…Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and fibromyalgia (FM) are two chronic complex diseases with overlapping symptoms affecting…”
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Identification of FAT3 as a new candidate gene for adolescent idiopathic scoliosis
Published in Scientific reports (19-07-2022)“…In an effort to identify rare alleles associated with adolescent idiopathic scoliosis (AIS) whole-exome sequencing was performed on a discovery cohort of 73…”
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Neuroinflammation, mitochondrial defects and neurodegeneration in mucopolysaccharidosis III type C mouse model
Published in Brain (London, England : 1878) (01-02-2015)“…Severe progressive neurological paediatric disease mucopolysaccharidosis III type C is caused by mutations in the HGSNAT gene leading to deficiency of…”
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E2F1 and TFDP1 Regulate PITX1 Expression in Normal and Osteoarthritic Articular Chondrocytes
Published in PloS one (01-11-2016)“…We previously reported a loss-of-PITX1 expression in patients suffering of knee/hip osteoarthritis (OA). Search for the mechanism underlying this event led us…”
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Direct interaction between the hepatitis B virus core and envelope proteins analyzed in a cellular context
Published in Scientific reports (07-11-2019)“…Hepatitis B virus (HBV) production requires intricate interactions between the envelope and core proteins. Analyses of mutants of these proteins have made it…”
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Dipeptidyl Peptidase-4 and Adolescent Idiopathic Scoliosis: Expression in Osteoblasts
Published in Scientific reports (09-06-2017)“…It has been proposed that girls with adolescent idiopathic scoliosis (AIS) tend to have a taller stature and a lower body mass index. Energy homeostasis, that…”
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Evolution of the Envelope Glycoprotein of HIV-1 Clade B toward Higher Infectious Properties over the Course of the Epidemic
Published in Journal of virology (15-03-2019)“…We showed previously that during the HIV/AIDS epidemic, the envelope glycoprotein (Env) of HIV-1, and in particular, the gp120 subunit, evolved toward an…”
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12
SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer
Published in Nature communications (05-12-2016)“…The development of metastases largely relies on the capacity of cancer cells to invade extracellular matrices (ECM) using two invasion modes termed…”
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Revisiting HBV resistance to entecavir with a phenotypic approach
Published in Antiviral research (01-09-2020)“…Treatment adaptation after hepatitis B virus (HBV) treatment failure relies on genotypic resistance testing. However, the results of such tests are not always…”
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Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules: Synthesis, electrochemical and SAR study
Published in European journal of medicinal chemistry (15-07-2018)“…To study the antiparasitic 8-nitroquinolin-2(1H)-one pharmacophore, a series of 31 derivatives was synthesized in 1–5 steps and evaluated in vitro against both…”
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Upregulation of microRNA-96-5p is associated with adolescent idiopathic scoliosis and low bone mass phenotype
Published in Scientific reports (11-06-2022)“…Bone densitometry revealed low bone mass in patients with adolescent idiopathic scoliosis (AIS) and its prognostic potential to predict curve progression…”
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Probing the compartmentalization of HIV-1 in the central nervous system through its neutralization properties
Published in PloS one (25-08-2017)“…Compartmentalization of HIV-1 has been observed in the cerebrospinal fluid (CSF) of patients at different clinical stages. Considering the low permeability of…”
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Phenotypic properties of envelope glycoproteins of transmitted HIV-1 variants from patients belonging to transmission chains
Published in AIDS (London) (10-09-2018)“…OBJECTIVE:Transmission of HIV-1 involves a bottleneck in which generally a single HIV-1 variant from a diverse viral population in the transmitting partner…”
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8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases
Published in European journal of medicinal chemistry (05-09-2018)“…Based on a previously identified antileishmanial 6,8-dibromo-3-nitroimidazo[1,2-a]pyridine derivative, a Suzuki-Miyaura coupling reaction at position 8 of the…”
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Circulatory Adipokines and Incretins in Adolescent Idiopathic Scoliosis: A Pilot Study
Published in Children (Basel) (25-10-2022)“…Adolescent idiopathic scoliosis (AIS) is a three-dimensional malformation of the spine of unknown cause that develops between 10 and 18 years old and affects…”
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Evidence for a continuous drift of the HIV-1 species towards higher resistance to neutralizing antibodies over the course of the epidemic
Published in PLoS pathogens (01-07-2013)“…We compared the neutralization sensitivity of early/transmitted HIV-1 variants from patients infected by subtype B viruses at 3 periods of the epidemic…”
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