Blood-soluble Fas levels are increased in type 2 diabetic patients with peripheral vascular disease

Blood-soluble Fas levels are increased in type 2 diabetic patients with peripheral vascular disease

To investigate the possible utility of plasma sFas (soluble Fas) levels as a marker of peripheral vascular disease (PVD) in type 2 diabetic patients, and the relationship between classical cardiovascular risk factors and sFas levels in these patients. sFas levels were measured in 57 type 2 diabetic...

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Bibliographic Details
Published in:Hormone and metabolic research Vol. 38; no. 10; p. 673
Main Authors: García-Unzueta, M T, Pesquera, C, Calzada, E, De la Mora, A, Muñoz, P, Llorca, J, Morchón, N, Fernández-González, M D, Amado, J A
Format: Journal Article
Language:English
Published: Germany 01-10-2006
Subjects:
Aged
Biomarkers - blood
Blood Glucose
Blood Pressure
Creatinine - blood
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - epidemiology
Diabetic Angiopathies - blood
Diabetic Angiopathies - diagnosis
Diabetic Angiopathies - epidemiology
fas Receptor - blood
Female
Humans
Lipids - blood
Male
Middle Aged
Risk Factors
Solubility
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Summary:To investigate the possible utility of plasma sFas (soluble Fas) levels as a marker of peripheral vascular disease (PVD) in type 2 diabetic patients, and the relationship between classical cardiovascular risk factors and sFas levels in these patients. sFas levels were measured in 57 type 2 diabetic patients with and 60 without PVD matched for age and sex. Diagnosis of PVD was established in presence of at least one of the following criteria: leg or foot amputation of vascular cause, lower-extremity arterial angioplasty or surgical by-pass, or ankle-braquial index (ABI) less than 1 in at least one side of the body. ELISA was used to measure sFas levels. None of the risk factors assessed total cholesterol, HDL cholesterol, triglycerides, CRP, ACE, fibrinogen, Lp(a) and homocysteine was significantly different between both groups of patients. However, patients with PVD had higher plasma sFas levels than the group without PVD (10.25+/-3.7 ng/ml VS. 8.86+/-2.6 ng/ml; p=0.02). Levels of sFas were 1.45 ng/ml (95% CI: 0.32-2.58; p=0.013) higher in PVD patients when adjusting by age, total, HDL and LDL cholesterol, triglycerides, homocysteine, CRP, ACE, arterial hypertension and tobacco smoking. Using multiple logistic regression sFas is a predictor of PVD, although not potent. Plasma sFas may be an independent marker of PVD in type 2 diabetes mellitus patients.
ISSN:0018-5043
DOI:10.1055/s-2006-954585