Search Results - "Morbidoni, Hector R."

Mutations in the essential FAS II β-hydroxyacyl ACP dehydratase complex confer resistance to thiacetazone in Mycobacterium tuberculosis and Mycobacterium kansasii by Belardinelli, Juan M., Morbidoni, Héctor R.

“…Summary It has recently been shown that the anti‐mycobacterial pro‐drug thiacetazone (TAC) inhibits the conversion of double bonds of mycolic acid precursors…”
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A Common Mechanism of Inhibition of the Mycobacterium tuberculosis Mycolic Acid Biosynthetic Pathway by Isoxyl and Thiacetazone by Grzegorzewicz, Anna E., Korduláková, Jana, Jones, Victoria, Born, Sarah E.M., Belardinelli, Juan M., Vaquié, Adrien, Gundi, Vijay A. K.B., Madacki, Jan, Slama, Nawel, Laval, Françoise, Vaubourgeix, Julien, Crew, Rebecca M., Gicquel, Brigitte, Daffé, Mamadou, Morbidoni, Hector R., Brennan, Patrick J., Quémard, Annaik, McNeil, Michael R., Jackson, Mary

“…Isoxyl (ISO) and thiacetazone (TAC), two prodrugs once used in the clinical treatment of tuberculosis, have long been thought to abolish Mycobacterium…”
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Induction of a Novel Class of Diacylglycerol Acyltransferases and Triacylglycerol Accumulation in Mycobacterium tuberculosis as It Goes into a Dormancy-Like State in Culture by DANIEL, Jaiyanth, DEB, Chirajyoti, DUBEY, Vinod S, SIRAKOVA, Tatiana D, ABOMOELAK, Bassam, MORBIDONI, Hector R, KOLATTUKUDY, Pappachan E

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Exploring the chemical space of 1,2,3-triazolyl triclosan analogs for discovery of new antileishmanial chemotherapeutic agents by Fernández de Luco, Julia, Recio-Balsells, Alejandro I, Ghiano, Diego G, Bortolotti, Ana, Belardinelli, Juán Manuel, Liu, Nina, Hoffmann, Pascal, Lherbet, Christian, Tonge, Peter J, Tekwani, Babu, Morbidoni, Héctor R, Labadie, Guillermo R

“…Triclosan and isoniazid are known antitubercular compounds that have proven to be also active against Leishmania parasites. On these grounds, a collection of…”
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Inactivation of the inhA-Encoded Fatty Acid Synthase II (FASII) Enoyl-Acyl Carrier Protein Reductase Induces Accumulation of the FASI End Products and Cell Lysis of Mycobacterium smegmatis by Vilchèze, Catherine, Morbidoni, Hector R., Weisbrod, Torin R., Iwamoto, Hiroyuki, Kuo, Mack, Sacchettini, James C., Jacobs, William R.

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Virulence factors of the Mycobacterium tuberculosis complex by Forrellad, Marina A., Klepp, Laura I., Gioffré, Andrea, Sabio y García, Julia, Morbidoni, Hector R., Santangelo, María de la Paz, Cataldi, Angel A., Bigi, Fabiana

“…The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that cause tuberculosis in both humans and animals. This illness, still…”
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New one-pot synthesis of anti-tuberculosis compounds inspired on isoniazid by Ghiano, Diego G., Recio-Balsells, Alejandro, Bortolotti, Ana, Defelipe, Lucas A., Turjanski, Adrián, Morbidoni, Héctor R., Labadie, Guillermo R.

“…A library of thirty N-substituted tosyl N’-acryl-hydrazones was prepared with p-toluenesulfonyl hydrazide, methyl propiolate and different aldehydes in a…”
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Broad-range lytic bacteriophages that kill Staphylococcus aureus local field strains by Abatángelo, Virginia, Peressutti Bacci, Natalia, Boncompain, Carina A, Amadio, Ariel F, Carrasco, Soledad, Suárez, Cristian A, Morbidoni, Héctor R

“…Staphylococcus aureus is a very successful opportunistic pathogen capable of causing a variety of diseases ranging from mild skin infections to…”
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Inhibition of InhA Activity, but Not KasA Activity, Induces Formation of a KasA-containing Complex in Mycobacteria by Kremer, Laurent, Dover, Lynn G., Morbidoni, Hector R., Vilchèze, Catherine, Maughan, William N., Baulard, Alain, Tu, Shiao-Chun, Honoré, Nadine, Deretic, Vojo, Sacchettini, James C., Locht, Camille, Jacobs, William, R., Besra, Gurdyal S.

“…Isoniazid (INH) remains one of the key drugs used to control tuberculosis, with the enoyl-AcpM reductase InhA being the primary target. However, based on the…”
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Antitubercular activity of 1,2,3-triazolyl fatty acid derivatives by Ghiano, Diego G., de la Iglesia, Agustina, Liu, Nina, Tonge, Peter J., Morbidoni, Héctor R., Labadie, Guillermo R.

“…A collection of 1,2,3-triazoles unsaturated fatty acid mimics were efficiently synthesized by click chemistry. The 1,4-disubstituted analogs prepared covered…”
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Repurposing antiparasitic N,N′‐aliphatic diamine derivatives as promising antimycobacterial agents by Recio‐Balsells, Alejandro I., Carlucci, Renzo, Giovannuzzi, Simone, Carta, Fabrizio, Supuran, Claudiu T., Tekwani, Babu L., Morbidoni, Héctor R., Labadie, Guillermo R.

“…In previous studies, we demonstrated the potent activity of a library of 25 N,N′‐disubstituted diamines (NNDDA) toward Trypanosomatid and Apicomplexa…”
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Complete auxotrophy for unsaturated fatty acids requires deletion of two sets of genes in Mycobacterium smegmatis by Di Capua, Cecilia B., Doprado, Mariana, Belardinelli, Juan Manuel, Morbidoni, Héctor R.

“…Summary The synthesis of unsaturated fatty acids in Mycobacterium smegmatis is poorly characterized. Bioinformatic analysis revealed four putative fatty acid…”
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Deletion of MSMEG_1350 in Mycobacterium smegmatis causes loss of epoxy-mycolic acids, fitness alteration at low temperature and resistance to a set of mycobacteriophages by Di Capua, Cecilia B, Belardinelli, Juan M, Buchieri, María V, Bortolotti, Ana, Franceschelli, Jorgelina J, Morbidoni, Héctor R

“…Mycobacterium smegmatis is intrinsically resistant to thiacetazone, an anti-tubercular thiourea; however we report here that it causes a mild inhibition in…”
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Bioinformatic Analysis of a Set of 14 Temperate Bacteriophages Isolated from Staphylococcus aureus Strains Highlights Their Massive Genetic Diversity by Suárez, Cristian A., Carrasco, Soledad T., Brandolisio, Facundo N. A., Abatangelo, Virginia, Boncompain, Carina A., Peresutti-Bacci, Natalia, Morbidoni, Héctor R.

“…Epidemiology and virulence studies of Staphylococcus aureus showed that temperate bacteriophages are one of the most powerful drivers for its evolution not…”
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Impact of the deletion of the six mce operons in Mycobacterium smegmatis by Klepp, Laura I., Forrellad, Marina A., Osella, Ana V., Blanco, Federico C., Stella, Emma J., Bianco, María Verónica, Santangelo, María de la Paz, Sassetti, Cristopher, Jackson, Mary, Cataldi, Angel A., Bigi, Fabiana, Morbidoni, Héctor R.

“…The Mycobacterium smegmatis genome contains six operons designated mce (mammalian cell entry). These operons, which encode membrane and exported proteins, are…”
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Inhibition of the β-carbonic anhydrases from Mycobacterium tuberculosis with C-cinnamoyl glycosides: Identification of the first inhibitor with anti-mycobacterial activity by Buchieri, María V., Riafrecha, Leonardo E., Rodríguez, Oscar M., Vullo, Daniela, Morbidoni, Héctor R., Supuran, Claudiu T., Colinas, Pedro A.

“…A small series of C-cinnamoyl glycoside containing the phenol moiety was tested for the inhibition of the three Mycobacterium tuberculosis β-carbonic…”
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Targeting tuberculosis through a small focused library of 1,2,3-triazoles by Labadie, Guillermo R., de la Iglesia, Agustina, Morbidoni, Héctor R.

“…Looking for new active molecules against Mycobacterium tuberculosis , a small focused library of 1,2,3-triazoles was efficiently prepared by click chemistry…”
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Analysis of novel mycobacteriophages indicates the existence of different strategies for phage inheritance in mycobacteria by Stella, Emma J, Franceschelli, Jorgelina J, Tasselli, Sabrina E, Morbidoni, Héctor R

“…Mycobacteriophages have been essential in the development of mycobacterial genetics through their use in the construction of tools for genetic manipulation…”
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A katG S315T or an ahpC promoter mutation mediate Mycobacterium tuberculosis resistance to 2-thiophen carboxylic acid hydrazide, an inhibitor resembling the anti-tubercular drugs Isoniazid and Ethionamide by Franceschelli, Jorgelina J., Belardinelli, Juan M., Tong, Ping, Loftus, Brendan, Recio-Balsells, Alejandro, Labadié, Guillermo R., Gordon, Stephen V., Morbidoni, Hector R.

“…Clinical isolates of Mycobacterium tuberculosis and Mycobacterium bovis are differentially susceptible to 2-Thiophen Hydrazide (TCH); however its mechanism of…”
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ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria by Kurth, Daniel G, Gago, Gabriela M, de la Iglesia, Agustina, Bazet Lyonnet, Bernardo, Lin, Ting-Wan, Morbidoni, Hector R, Tsai, Shiou-Chuan, Gramajo, Hugo

“…1 Microbiology Division, Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad…”
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