Search Results - "Moravec, Christine"

Cardiomyocyte contractile impairment in heart failure results from reduced BAG3-mediated sarcomeric protein turnover by Martin, Thomas G., Myers, Valerie D., Dubey, Praveen, Dubey, Shubham, Perez, Edith, Moravec, Christine S., Willis, Monte S., Feldman, Arthur M., Kirk, Jonathan A.

“…The association between reduced myofilament force-generating capacity (F max ) and heart failure (HF) is clear, however the underlying molecular mechanisms are…”
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RNA-Seq identifies novel myocardial gene expression signatures of heart failure by Liu, Yichuan, Morley, Michael, Brandimarto, Jeffrey, Hannenhalli, Sridhar, Hu, Yu, Ashley, Euan A., Tang, W.H. Wilson, Moravec, Christine S., Margulies, Kenneth B., Cappola, Thomas P., Li, Mingyao

“…Heart failure is a complex clinical syndrome and has become the most common reason for adult hospitalization in developed countries. Two subtypes of heart…”
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SIRT6 Mitigates Heart Failure With Preserved Ejection Fraction in Diabetes by Wu, Xiaoqian, Liu, Huan, Brooks, Alan, Xu, Suowen, Luo, Jinque, Steiner, Rebbeca, Mickelsen, Deanne M., Moravec, Christine S., Alexis, Jeffrey D., Small, Eric M., Jin, Zheng Gen

“…Heart failure with preserved ejection fraction (HFpEF) is a growing health problem without effective therapies. Epidemiological studies indicate that diabetes…”
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Circadian Pattern of Ion Channel Gene Expression in Failing Human Hearts by McTiernan, Charles F., Lemster, Bonnie H., Bedi, Kenneth C., Margulies, Kenneth B., Moravec, Christine S., Hsieh, Paishiun Nelson, Shusterman, Vladimir, Saba, Samir

“…Ventricular tachyarrhythmias and sudden cardiac death show a circadian pattern of occurrence in patients with heart failure. In the rodent ventricle, a…”
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Targeted DNA Methylation Profiling of Human Cardiac Tissue Reveals Novel Epigenetic Traits and Gene Deregulation Across Different Heart Failure Patient Subtypes by Glezeva, Nadezhda, Moran, Bruce, Collier, Patrick, Moravec, Christine S, Phelan, Dermot, Donnellan, Eoin, Russell-Hallinan, Adam, O'Connor, Darran P, Gallagher, William M, Gallagher, Joe, McDonald, Kenneth, Ledwidge, Mark, Baugh, John, Das, Sudipto, Watson, Chris J

“…Limited knowledge exists of the extent of epigenetic alterations, such as DNA methylation, in heart failure (HF). We conducted targeted DNA methylation…”
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An Enhancer Polymorphism at the Cardiomyocyte Intercalated Disc Protein NOS1AP Locus Is a Major Regulator of the QT Interval by Kapoor, Ashish, Sekar, Rajesh B., Hansen, Nancy F., Fox-Talbot, Karen, Morley, Michael, Pihur, Vasyl, Chatterjee, Sumantra, Brandimarto, Jeffrey, Moravec, Christine S., Pulit, Sara L., Pfeufer, Arne, Mullikin, Jim, Ross, Mark, Green, Eric D., Bentley, David, Newton-Cheh, Christopher, Boerwinkle, Eric, Tomaselli, Gordon F., Cappola, Thomas P., Arking, Dan E., Halushka, Marc K., Chakravarti, Aravinda

“…QT interval variation is assumed to arise from variation in repolarization as evidenced from rare Na- and K-channel mutations in Mendelian QT prolongation…”
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Gut microbe-generated phenylacetylglutamine is an endogenous allosteric modulator of β2-adrenergic receptors by Saha, Prasenjit Prasad, Gogonea, Valentin, Sweet, Wendy, Mohan, Maradumane L., Singh, Khuraijam Dhanachandra, Anderson, James T., Mallela, Deepthi, Witherow, Conner, Kar, Niladri, Stenson, Kate, Harford, Terri, Fischbach, Michael A., Brown, J. Mark, Karnik, Sadashiva S., Moravec, Christine S., DiDonato, Joseph A., Naga Prasad, Sathyamangla Venkata, Hazen, Stanley L.

“…Allosteric modulation is a central mechanism for metabolic regulation but has yet to be described for a gut microbiota-host interaction. Phenylacetylglutamine…”
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A unique microRNA profile in end-stage heart failure indicates alterations in specific cardiovascular signaling networks by Naga Prasad, Sathyamangla V, Gupta, Manveen K, Duan, Zhong-Hui, Surampudi, Venkata Suresh K, Liu, Chang-Gong, Kotwal, Ashwin, Moravec, Christine S, Starling, Randall C, Perez, Dianne M, Sen, Subha, Wu, Qingyu, Plow, Edward F, Karnik, Sadashiva

“…It is well established that the gene expression patterns are substantially altered in cardiac hypertrophy and heart failure, however, less is known about the…”
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GSK-3β Localizes to the Cardiac Z-Disc to Maintain Length Dependent Activation by Stachowski-Doll, Marisa J., Papadaki, Maria, Martin, Thomas G., Ma, Weikang, Gong, Henry M., Shao, Stephanie, Shen, Shi, Muntu, Nitha Aima, Kumar, Mohit, Perez, Edith, Martin, Jody L., Moravec, Christine S., Sadayappan, Sakthivel, Campbell, Stuart G., Irving, Thomas, Kirk, Jonathan A.

“…Altered kinase localization is gaining appreciation as a mechanism of cardiovascular disease. Previous work suggests GSK-3β (glycogen synthase kinase 3β)…”
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Atrial Fibrillation associated chromosome 4q25 variants are not associated with PITX2c expression in human adult left atrial appendages by Gore-Panter, Shamone R, Hsu, Jeffery, Hanna, Peter, Gillinov, A Marc, Pettersson, Gosta, Newton, David W, Moravec, Christine S, Van Wagoner, David R, Chung, Mina K, Barnard, John, Smith, Jonathan D

“…Atrial Fibrillation (AF), the most common sustained arrhythmia, has a strong genetic component, but the mechanism by which common genetic variants lead to…”
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Differential expression of members of SOX family of transcription factors in failing human hearts by Liu, Chia-Feng, Ni, Ying, Thachil, Varun, Morley, Michael, Moravec, Christine S., Tang, Wai Hong Wilson

“…The Sry-related high-mobility-group box (SOX) gene family, with 20 known transcription factors in humans, plays an essential role during development and…”
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Mechanosensitive Gene Regulation by Myocardin-Related Transcription Factors Is Required for Cardiomyocyte Integrity in Load-Induced Ventricular Hypertrophy by Trembley, Michael A, Quijada, Pearl, Agullo-Pascual, Esperanza, Tylock, Kevin M, Colpan, Mert, Dirkx, Ronald A, Myers, Jason R, Mickelsen, Deanne M, de Mesy Bentley, Karen, Rothenberg, Eli, Moravec, Christine S, Alexis, Jeffrey D, Gregorio, Carol C, Dirksen, Robert T, Delmar, Mario, Small, Eric M

“…BACKGROUND:Hypertrophic cardiomyocyte growth and dysfunction accompany various forms of heart disease. The mechanisms responsible for transcriptional changes…”
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Global analysis of histone modifications and long-range chromatin interactions revealed the differential cistrome changes and novel transcriptional players in human dilated cardiomyopathy by Liu, Chia-Feng, Abnousi, Armen, Bazeley, Peter, Ni, Ying, Morley, Michael, Moravec, Christine S., Hu, Ming, Tang, W.H. Wilson

“…Acetylation and methylation of histones alter the chromatin structure and accessibility that affect transcriptional regulators binding to enhancers and…”
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Small proline-rich protein 2B drives stress-dependent p53 degradation and fibroblast proliferation in heart failure by Burke, Ryan M., Lighthouse, Janet K., Quijada, Pearl, Dirkx, Ronald A., Rosenberg, Alexander, Moravec, Christine S., Alexis, Jeffrey D., Small, Eric M.

“…Heart disease is associated with the accumulation of resident cardiac fibroblasts (CFs) that secrete extracellular matrix (ECM), leading to the development of…”
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Yes-Associated Protein (Yap) Is Up-Regulated in Heart Failure and Promotes Cardiac Fibroblast Proliferation by Sharifi-Sanjani, Maryam, Berman, Mariah, Goncharov, Dmitry, Alhamaydeh, Mohammad, Avolio, Theodore Guy, Baust, Jeffrey, Chang, Baojun, Kobir, Ahasanul, Ross, Mark, St. Croix, Claudette, Nouraie, Seyed Mehdi, McTiernan, Charles F., Moravec, Christine S., Goncharova, Elena, Al Ghouleh, Imad

“…Left ventricular (LV) heart failure (HF) is a significant and increasing cause of death worldwide. HF is characterized by myocardial remodeling and excessive…”
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Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure by Cordero, Pablo, Parikh, Victoria N., Chin, Elizabeth T., Erbilgin, Ayca, Gloudemans, Michael J., Shang, Ching, Huang, Yong, Chang, Alex C., Smith, Kevin S., Dewey, Frederick, Zaleta, Kathia, Morley, Michael, Brandimarto, Jeff, Glazer, Nicole, Waggott, Daryl, Pavlovic, Aleksandra, Zhao, Mingming, Moravec, Christine S., Tang, W. H. Wilson, Skreen, Jamie, Malloy, Christine, Hannenhalli, Sridhar, Li, Hongzhe, Ritter, Scott, Li, Mingyao, Bernstein, Daniel, Connolly, Andrew, Hakonarson, Hakon, Lusis, Aldons J., Margulies, Kenneth B., Depaoli-Roach, Anna A., Montgomery, Stephen B., Wheeler, Matthew T., Cappola, Thomas, Ashley, Euan A.

“…Heart failure is a leading cause of mortality, yet our understanding of the genetic interactions underlying this disease remains incomplete. Here, we harvest…”
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Contribution of two-pore K + channels to cardiac ventricular action potential revealed using human iPSC-derived cardiomyocytes by Chai, Sam, Wan, Xiaoping, Nassal, Drew M, Liu, Haiyan, Moravec, Christine S, Ramirez-Navarro, Angelina, Deschênes, Isabelle

“…Two-pore K (K ) channels have been described in modulating background conductance as leak channels in different physiological systems. In the heart, the…”
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Human Cardiac Mesenchymal Stem Cells Remodel in Disease and Can Regulate Arrhythmia Substrates by Sattayaprasert, Prasongchai, Vasireddi, Sunil K., Bektik, Emre, Jeon, Oju, Hajjiri, Mohammad, Mackall, Judith A., Moravec, Christine S., Alsberg, Eben, Fu, Jidong, Laurita, Kenneth R.

“…BACKGROUND–The mesenchymal stem cell (MSC), known to remodel in disease and have an extensive secretome, has recently been isolated from the human heart…”
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Protease corin expression and activity in failing hearts by Chen, Shenghan, Sen, Subha, Young, David, Wang, Wei, Moravec, Christine S, Wu, Qingyu

“…Atrial and brain natriuretic peptides (ANP and BNP) regulate blood pressure and cardiac function. In patients with heart failure (HF), plasma levels of pro-ANP…”
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Novel and Annotated Long Noncoding RNAs Associated with Ischemia in the Human Heart by Ward, Zoe, Schmeier, Sebastian, Saddic, Louis, Sigurdsson, Martin I, Cameron, Vicky A, Pearson, John, Miller, Allison, Morley-Bunker, Arthur, Gorham, Josh, Seidman, Jonathan G, Moravec, Christine S, Sweet, Wendy E, Aranki, Sary F, Body, Simon, Muehlschlegel, Jochen D, Pilbrow, Anna P

“…Long noncoding RNAs (lncRNAs) have been implicated in the pathogenesis of cardiovascular diseases. We aimed to identify novel lncRNAs associated with the early…”
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