Search Results - "Morant, Steve"

Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial by Williams, Bryan, Prof, MacDonald, Thomas M, Prof, Morant, Steve, PhD, Webb, David J, Prof, Sever, Peter, Prof, McInnes, Gordon, Prof, Ford, Ian, Prof, Cruickshank, J Kennedy, Prof, Caulfield, Mark J, Prof, Salsbury, Jackie, Prof, Mackenzie, Isla, FRCP, Padmanabhan, Sandosh, FRCP, Brown, Morris J, Prof

“…Summary Background Optimal drug treatment for patients with resistant hypertension is undefined. We aimed to test the hypotheses that resistant hypertension is…”
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Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies by Williams, Bryan, MacDonald, Thomas M, Morant, Steve V, Webb, David J, Sever, Peter, McInnes, Gordon T, Ford, Ian, Cruickshank, J Kennedy, Caulfield, Mark J, Padmanabhan, Sandosh, Mackenzie, Isla S, Salsbury, Jackie, Brown, Morris J, Balakrishnan, K, Burton, T, Cannon, J, Collier, D, Coughlan, C, D'Souza, R, Enobakhare, E, Findlay, E, Gardiner-Hill, C, Gupta, P, Helmy, J, Helmy, C, Hobbs, L, Hobbs, R, Hood, S, Iles, R, Kean, S, Kwok, S, Lacy, P, MacIntyre, I, Mackay, J, Markandu, N, Martin, U, McCallum, L, McCann, G, McGinnis, A, Melville, V, Muir, S, Myint, KS, Nazir, S, Palmer, J, Papworth, R, Rutkowski, K, Saxena, M, Schumann, A, Soran, H, Stanley, A, Thom, S, Webb, A, White, C, Wilson, R, Zak, A

“…In the PATHWAY-2 study of resistant hypertension, spironolactone reduced blood pressure substantially more than conventional antihypertensive drugs. We did…”
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How effective are trained dogs at alerting their owners to changes in blood glycaemic levels?: Variations in performance of glycaemia alert dogs by Rooney, Nicola J, Guest, Claire M, Swanson, Lydia C M, Morant, Steve V

“…Domestic dogs are trained to a wide variety of roles including an increasing number of medical assistance tasks. Glycaemia alert dogs are reported to greatly…”
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Investigation into the value of trained glycaemia alert dogs to clients with type I diabetes by Rooney, Nicola J, Morant, Steve, Guest, Claire

“…Previous studies have suggested that some pet dogs respond to their owners' hypoglycaemic state. Here, we show that trained glycaemia alert dogs placed with…”
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Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial by Brown, Morris J, Prof, Williams, Bryan, Prof, Morant, Steve V, PhD, Webb, David J, Prof, Caulfield, Mark J, Prof, Cruickshank, J Kennedy, Prof, Ford, Ian, Prof, McInnes, Gordon, Prof, Sever, Peter, Prof, Salsbury, Jackie, RGN, Mackenzie, Isla S, FRCP, Padmanabhan, Sandosh, FRCP, MacDonald, Thomas M, Prof

“…Summary Background Potassium depletion by thiazide diuretics is associated with a rise in blood glucose. We assessed whether addition or substitution of a…”
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Acid‐suppression medications and bacterial gastroenteritis: a population‐based cohort study by Wei, Li, Ratnayake, Lasantha, Phillips, Gabby, McGuigan, Chris C., Morant, Steve V., Flynn, Robert W., Mackenzie, Isla S., MacDonald, Thomas M.

“…Aims To investigate whether acid‐suppression medicines (ASMs) increase the risk of bacterial gastroenteritis. Methods A population‐based, propensity‐score…”
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Adverse events and overall health and well-being after COVID-19 vaccination: interim results from the VAC4COVID cohort safety study by Rogers, Amy, Rooke, Evelien, Morant, Steve, Guthrie, Greg, Doney, Alex, Duncan, Andrew, Mackenzie, Isla, Barr, Rebecca, Pigazzani, Filippo, Zutis, Krists, MacDonald, Thomas M

“…ObjectivesTo describe the incidence of adverse events (AEs), reactogenicity symptoms, menstrual changes and overall self-rated improvement in health and…”
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Diabetes alert dogs: Objective behaviours shown during periods of owner glucose fluctuation and stability by Wilson, Clara H, Kane, Sarah A, Morant, Steve V, Guest, Claire M, Rooney, Nicola J

“…•Diabetes Alert Dogs show differences in behaviour when their owner’s glucose levels fluctuate.•Dogs elicit trained and non-trained behaviours when their owner…”
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Evaluating Diuretics in Normal Care (EVIDENCE): protocol of a cluster randomised controlled equivalence trial of prescribing policy to compare the effectiveness of thiazide-type diuretics in hypertension by Rogers, Amy, Flynn, Angela, Mackenzie, Isla S, McConnachie, Lewis, Barr, Rebecca, Flynn, Robert W V, Morant, Steve, MacDonald, Thomas M, Doney, Alexander

“…Healthcare systems must use treatments that are effective and safe. Regulators licensed many currently used older medications before introducing the stringent…”
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Biomarker report from the phase II lamotrigine trial in secondary progressive MS - neurofilament as a surrogate of disease progression by Gnanapavan, Sharmilee, Grant, Donna, Morant, Steve, Furby, Julian, Hayton, Tom, Teunissen, Charlotte E, Leoni, Valerio, Marta, Monica, Brenner, Robert, Palace, Jacqueline, Miller, David H, Kapoor, Raj, Giovannoni, Gavin

“…Lamotrigine trial in SPMS was a randomised control trial to assess whether partial blockade of sodium channels has a neuroprotective effect. The current study…”
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Impact of EMA regulatory label changes on systemic diclofenac initiation, discontinuation, and switching to other pain medicines in Scotland, England, Denmark, and The Netherlands by Morales, Daniel R., Morant, Steve V., MacDonald, Thomas M., Mackenzie, Isla S., Doney, Alexander S. F., Mitchell, Lyn, Bennie, Marion, Robertson, Chris, Hallas, Jesper, Pottegard, Anton, Ernst, Martin Thomsen, Wei, Li, Nicholson, Lizzie, Morris, Carole, Herings, Ron M. C., Overbeek, Jetty A., Smits, Elisabeth, Flynn, Robert W. V.

“…Purpose In June 2013 a European Medicines Agency referral procedure concluded that diclofenac was associated with an elevated risk of acute cardiovascular…”
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Effect of timed dosing of usual antihypertensives according to patient chronotype on cardiovascular outcomes: the Chronotype sub-study cohort of the Treatment in Morning versus Evening (TIME) study by Pigazzani, Filippo, Dyar, Kenneth A., Morant, Steve V., Vetter, Céline, Rogers, Amy, Flynn, Robert W.V., Rorie, David A., Mackenzie, Isla S., Cappuccio, Francesco P., Manfredini, Roberto, MacDonald, Thomas M.

“…Timing drug administration to endogenous circadian rhythms may enhance treatment efficacy. In the Chronotype sub-study of the Treatment in Morning versus…”
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P.55 Dietary Nitrate Prevents Progression of Carotid Subclinical Atherosclerosis Through BP-Independent Mechanisms in Patients with or at Risk of Type 2 Diabetes Mellitus: Results from the Double-Blind, Randomized-Controlled, Factorial Vasera Trial by Morselli, Franca, Faconti, Luca, Mills, Charlotte E, Morant, Steve, Chowienczyk, Philip J, Cruickshank, J Kennedy, Webb, Andrew J, Cavarape, Alessandro

“…Background Epidemiological and animal studies suggest the potential of dietary nitrate (NO 3 − ) to inhibit atherogenesis. Spironolactone may improve arterial…”
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An Owner-Independent Investigation of Diabetes Alert Dog Performance by Wilson, Clara, Morant, Steve, Kane, Sarah, Pesterfield, Claire, Guest, Claire, Rooney, Nicola J

“…To quantify Diabetes Alert Dog (DAD) performance by using owner-independent measures. Eight owners of accredited DADs used a FreeStyle Libre Flash Glucose…”
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Reducing arterial stiffness independently of BP: Proof of concept? CAVI, PWV and cardiac data in the 6-month VaSera trial by Mills, Charlotte, Dr, Faconti, Luca, Dr, Govoni, Virginia, Ms, Morant, Steve, Dr, Casagrande, Maria-Linda, Dr, Gu, Haotian, Dr, Jiang, Benyu, Dr, Webb, Andrew, Dr, Cruickshank, Kennedy, Professor

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An observational descriptive study of the epidemiology and treatment of neuropathic pain in a UK general population by Hall, Gillian C, Morant, Steve V, Carroll, Dawn, Gabriel, Zahava L, McQuay, Henry J

“…This study updated our knowledge of UK primary care neuropathic pain incidence rates and prescribing practices. Patients with a first diagnosis of…”
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3.1 REDUCING ARTERIAL STIFFNESS INDEPENDENTLY OF BP: PROOF OF CONCEPT? CAVI, PWV AND CARDIAC DATA IN THE 6-MONTH VASERA TRIAL by Mills, Charlotte, Faconti, Luca, Govoni, Virginia, Morant, Steve, Casagrande, Maria-Linda, Gu, Haotian, Jiang, Benyu, Webb, Andrew, Cruickshank, Kennedy

“…Purpose/ background/ objectives: People with or at risk of Type II diabetes (T2DM) are at increased risk of vascular disease and arterial stiffness (AS). We…”
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Drug treatment discontinuation and achievement of target blood pressure and cholesterol in United Kingdom primary care by MacDonald, Thomas M., Morant, Steve V., Mozaffari, Essy

“…ABSTRACT Aim: This cohort study evaluated medication discontinuation and target achievement in a United Kingdom primary care setting. Methods: The study…”
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Serum neurofilament is associated with progression of brain atrophy and disability in early MS by Kuhle, Jens, Nourbakhsh, Bardia, Grant, Donna, Morant, Steve, Barro, Christian, Yaldizli, Özgür, Pelletier, Daniel, Giovannoni, Gavin, Waubant, Emmanuelle, Gnanapavan, Sharmilee

“…OBJECTIVE:To investigate a potential effect of riluzole on serum neurofilaments (Nf) compared to placebo and the relationship between longitudinal clinical and…”
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Training dogs to differentiate Pseudomonas aeruginosa from other cystic fibrosis bacterial pathogens: not to be sniffed at? by Davies, Jane C, Alton, Eric, Simbo, Ameze, Murphy, Ronan, Seth, Ishani, Williams, Kate, Somerville, Mark, Jolly, Libby, Morant, Steve, Guest, Claire

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