Search Results - "Morano, A"

Biology of the Heat Shock Response and Protein Chaperones: Budding Yeast (Saccharomyces cerevisiae) as a Model System by VERGHESE, Jacob, ABRAMS, Jennifer, YANYU WANG, MORANO, Kevin A

“…Article Usage Stats Services MMBR Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A PPP-type pseudophosphatase is required for the maintenance of basal complex integrity in Plasmodium falciparum by Morano, Alexander A., Rudlaff, Rachel M., Dvorin, Jeffrey D.

“…During its asexual blood stage, P. falciparum replicates via schizogony, wherein dozens of daughter cells are formed within a single parent. The basal complex,…”
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Anhydrobiosis: Drying Out with Sugar by Morano, Kevin A.

“…The disaccharide trehalose is a major determinant of desiccation tolerance via unresolved mechanisms. A new study highlights a critical role for this chemical…”
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LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription by Amente, S, Bertoni, A, Morano, A, Lania, L, Avvedimento, E V, Majello, B

“…Myc is a transcription factor that significantly contributes to cancer progression by modulating the expression of important genes through binding to a DNA…”
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The Ringleaders: Understanding the Apicomplexan Basal Complex Through Comparison to Established Contractile Ring Systems by Morano, Alexander A, Dvorin, Jeffrey D

“…The actomyosin contractile ring is a key feature of eukaryotic cytokinesis, conserved across many eukaryotic kingdoms. Recent research into the cell biology of…”
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Thiol stress-dependent aggregation of the glycolytic enzyme triose phosphate isomerase in yeast and human cells by Ford, Amy E, Denicourt, Catherine, Morano, Kevin A

“…The eukaryotic cytosolic proteome is vulnerable to changes in proteostatic and redox balance caused by temperature, pH, oxidants, and xenobiotics…”
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When pH comes to the rescue by Gonçalves, Davi, Santiago, Alec, Morano, Kevin A

“…In starving yeast exposed to thermal stress, a transient drop in intracellular pH helps to trigger the heat shock response…”
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Small Molecule Activators of the Heat Shock Response: Chemical Properties, Molecular Targets, and Therapeutic Promise by West, James D, Wang, Yanyu, Morano, Kevin A

“…All cells have developed various mechanisms to respond and adapt to a variety of environmental challenges, including stresses that damage cellular proteins…”
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Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule by Trott, Amy, West, James D, Klaić, Lada, Westerheide, Sandy D, Silverman, Richard B, Morimoto, Richard I, Morano, Kevin A

“…Stress response pathways allow cells to sense and respond to environmental changes and adverse pathophysiological states. Pharmacological modulation of…”
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The yeast Hsp70 Ssa1 is a sensor for activation of the heat shock response by thiol-reactive compounds by Wang, Yanyu, Gibney, Patrick A, West, James D, Morano, Kevin A

“…The heat shock transcription factor HSF1 governs the response to heat shock, oxidative stresses, and xenobiotics through unknown mechanisms. We demonstrate…”
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Structure of the Hsp110:Hsc70 Nucleotide Exchange Machine by Schuermann, Jonathan P., Jiang, Jianwen, Cuellar, Jorge, Llorca, Oscar, Wang, Liping, Gimenez, Luis E., Jin, Suping, Taylor, Alexander B., Demeler, Borries, Morano, Kevin A., Hart, P. John, Valpuesta, Jose M., Lafer, Eileen M., Sousa, Rui

“…Hsp70s mediate protein folding, translocation, and macromolecular complex remodeling reactions. Their activities are regulated by proteins that exchange ADP…”
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Characterization of Hsp70 Binding and Nucleotide Exchange by the Yeast Hsp110 Chaperone Sse1 by Shaner, Lance, Sousa, Rui, Morano, Kevin A

“…SSE1 and SSE2 encode the essential yeast members of the Hsp70-related Hsp110 molecular chaperone family. Both mammalian Hsp110 and the Sse proteins…”
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Hsp90 nuclear accumulation in quiescence is linked to chaperone function and spore development in yeast by Tapia, Hugo, Morano, Kevin A

“…The 90-kDa heat-shock protein (Hsp90) operates in the context of a multichaperone complex to promote maturation of nuclear and cytoplasmic clients. We have…”
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A Lysine-Rich Region within Fungal BAG Domain-Containing Proteins Mediates a Novel Association with Ribosomes by Verghese, Jacob, Morano, Kevin A

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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All in the family: atypical Hsp70 chaperones are conserved modulators of Hsp70 activity by Shaner, Lance, Morano, Kevin A.

“…Divergent relatives of the Hsp70 protein chaperone such as the Hsp110 and Grp170 families have been recognized for some time, yet their biochemical roles…”
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Understanding and exploiting interactions between cellular proteostasis pathways and infectious prion proteins for therapeutic benefit by Yakubu, Unekwu M, Catumbela, Celso S G, Morales, Rodrigo, Morano, Kevin A

“…Several neurodegenerative diseases of humans and animals are caused by the misfolded prion protein (PrP ), a self-propagating protein infectious agent that…”
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Firing patterns in a random network cellular automata model of the brain by Acedo, L., Lamprianidou, E., Moraño, J.-A., Villanueva-Oller, J., Villanueva, R.-J.

“…One of the main challenges in the simulation of even reduced areas of the brain is the presence of a large number of neurons and a large number of connections…”
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The Yeast Hsp110 Sse1 Functionally Interacts with the Hsp70 Chaperones Ssa and Ssb by Shaner, Lance, Wegele, Harald, Buchner, Johannes, Morano, Kevin A.

“…There is growing evidence that members of the extended Hsp70 family of molecular chaperones, including the Hsp110 and Grp170 subgroups, collaborate in vivo to…”
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Brain oscillations in a random neural network by Acedo, L., Moraño, J.-A.

“…It is well-known that rhythmic patterns of neural activity appear both in the normal and abnormal function of the brain. Apart from the standard bands of…”
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Hsp110 chaperones control client fate determination in the hsp70-Hsp90 chaperone system by Mandal, Atin K, Gibney, Patrick A, Nillegoda, Nadinath B, Theodoraki, Maria A, Caplan, Avrom J, Morano, Kevin A

“…Heat shock protein 70 (Hsp70) plays a central role in protein homeostasis and quality control in conjunction with other chaperone machines, including Hsp90…”
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