Search Results - "Morand, O."

Lucerastat, an iminosugar with potential as substrate reduction therapy for glycolipid storage disorders: safety, tolerability, and pharmacokinetics in healthy subjects by Guérard, N, Morand, O, Dingemanse, J

“…Lucerastat, an inhibitor of glucosylceramide synthase, has the potential to restore the balance between synthesis and degradation of glycosphingolipids in…”
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Glucosylceramide synthase inhibition with lucerastat lowers globotriaosylceramide and lysosome staining in cultured fibroblasts from Fabry patients with different mutation types by Welford, R W D, Mühlemann, A, Garzotti, M, Rickert, V, Groenen, P M A, Morand, O, Üçeyler, N, Probst, M R

“…Abstract Fabry disease is an X-linked lysosomal storage disorder caused by mutations in the GLA gene coding for α-galactosidase A (α-GalA). The deleterious…”
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The pharmacokinetics and tissue distribution of the glucosylceramide synthase inhibitor miglustat in the rat by Treiber, A., Morand, O., Clozel, M.

“…Miglustat (Zavesca™) is a reversible inhibitor of glucosylceramide synthase, which catalyses the first step in the glucosylceramide biosynthetic pathway, and…”
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Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin by Morand, O H, Aebi, J D, Dehmlow, H, Ji, Y H, Gains, N, Lengsfeld, H, Himber, J

“…2,3-Oxidosqualene:lanosterol cyclase (OSC, E.C. 5.4.99.7) represents a unique target for a cholesterol lowering drug. Partial inhibition of OSC should reduce…”
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A possible role for plasmalogens in protecting animal cells against photosensitized killing by Zoeller, R A, Morand, O H, Raetz, C R

“…Chinese hamster ovary (CHO) cells incorporate 12-(1′-pyrene) dodecanoic acid (P12) into membrane lipids. Exposure of P12-labeled cells to long wavelength…”
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Inequality, mobility, and the transmission of ability by Morand, O.F.

“…In view of the empirical evidence supporting the role of inheritance of cognitive skills in the determination of economic status presented in this paper, we…”
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Disappearance of plasmalogens from membranes of animal cells subjected to photosensitized oxidation by Morand, O H, Zoeller, R A, Raetz, C R

“…Chinese hamster ovary cells (CHO-K1) photosensitized with 12-(1′-pyrene)dodecanoic acid (P12) are killed when exposed to long wavelength ultraviolet (UV) light…”
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Inequality, mobility, and the transmission of ability by Couch, K.A., Morand, O.F.

“…In view of the empirical evidence supporting the role of inheritance of cognitive skills in the determination of economic status presented in this paper, we…”
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ACCEPTCARDIO1: Criteria associated with patient willingness to participate in biomedical research in cardiology by Soltani, S., Morand, O., Galtier, E., Desmoulins, G., Cardeur, L., Faucanie, M., Molinari, N., Vidal, C., Vachier, I., Bourdin, A., Delbaere, Q., Leclercq, F., Pasquié, J.-L., Roubille, F.

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Enhanced Synthesis of the Oxysterol 24(S),25-Epoxycholesterol in Macrophages by Inhibitors of 2,3-Oxidosqualene:Lanosterol Cyclase: A Novel Mechanism for the Attenuation of Foam Cell Formation by Rowe, Andrea H, Argmann, Carmen A, Edwards, Jane Y, Sawyez, Cynthia G, Morand, Olivier H, Hegele, Robert A, Huff, Murray W

“…ABSTRACT—Oxysterols are key regulators of lipid metabolism and regulate gene expression by activating the liver X receptor (LXR). LXR plays a vital role in…”
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Decrease in Scavenger Receptor Expression in Human Monocyte-Derived Macrophages Treated With Granulocyte Macrophage Colony-Stimulating Factor by van der Kooij, Maaike A, Morand, Olivier H, Kempen, Herman J, van Berkel, Theo J.C

“…To determine whether scavenger receptors are susceptible to regulation by granulocyte macrophage colony-stimulating factor (GM-CSF), a macrophage-specific…”
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A rapid selection for animal cell mutants with defective peroxisomes by Morand, O H, Allen, L A, Zoeller, R A, Raetz, C R

“…Chinese hamster ovary (CHO) cells take up and incorporate 9-(1'-pyrene)nonanol (P9OH) into phospholipids and neutral lipids. Exposure of P9OH-labeled cells to…”
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Markovian equilibrium in infinite horizon economies with incomplete markets and public policy by Datta, Manjira, Mirman, Leonard J., Morand, Olivier F., Reffett, Kevin L.

“…We develop an isotone recursive approach to the problem of existence, computation, and characterization of nonsymmetric locally Lipschitz continuous (and,…”
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Cytoplasmic Requirement for Peroxisome Biogenesis in Chinese Hamster Ovary Cells by Allen, Lee-Ann H., Morand, Olivier H., Christian R. H. Raetz

“…Hybrids constructed by fusion of wild-type Chinese hamster ovary cells (CHO-K1) to peroxisome-deficient CHO mutants (ZR-78.1) contain normal peroxisomes,…”
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A Novel Inhibitor of Oxidosqualene:Lanosterol Cyclase Inhibits Very Low–Density Lipoprotein Apolipoprotein B100 (ApoB100) Production and Enhances Low-Density Lipoprotein ApoB100 Catabolism Through Marked Reduction in Hepatic Cholesterol Content by Telford, Dawn E, Lipson, Sara M, Barrett, P Hugh R, Sutherland, Brian G, Edwards, Jane Y, Aebi, Johannes D, Dehmlow, Henrietta, Morand, Olivier H, Huff, Murray W

“…OBJECTIVE—Inhibition of 2,3-oxidosqualene:lanosterol cyclase (OSC), an enzyme in the cholesterol synthesis pathway, has the unique ability to inhibit…”
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Down-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels and synthesis in Syrian hamster C100 cells by the oxidosqualene cyclase inhibitor [4′-(6-allyl-ethyl-amino-hexyloxy)-2′-fluoro-phenyl]-(4-bromophenyl)-methanone (Ro 48–8071): comparison to simvastatin by Peffley, Dennis M., Gayen, Apurba K., Morand, Olivier H.

“…In vivo inhibition of 2,3-oxidosqualene:lanosterol cyclase (OSC, E.C. 5.4.99.7)—the enzyme which catalyzes the cyclization of monooxidosqualene to…”
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Effects of chronic aortic coarctation on atherosclerosis and arterial lipid accumulation in the Watanabe hereditary hyperlipidemic (WHHL) rabbit by Roux, S P, Kuhn, H, Lengsfeld, H, Morand, O H

“…The effects of high blood pressure on atherosclerosis were examined in the Watanabe heritable hyperlipidemic (WHHL) rabbit. For this purpose, the…”
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Sphingomyelin Synthase and PKC Activation by Hampton, Randolph Y., Morand, Olivier H.

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A qualitative approach to Markovian equilibrium in infinite horizon economies with capital by Mirman, Leonard J., Morand, Olivier F., Reffett, Kevin L.

“…Using lattice programming and order theoretic fixpoint theory, we develop a new class of monotone iterative methods that provide a qualitative theory of…”
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Reactivity of plasmalogens to singlet oxygen and radicals by Morand, O H

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