Search Results - "Moran, Rita"
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The microprotein Minion controls cell fusion and muscle formation
Published in Nature communications (01-06-2017)“…Although recent evidence has pointed to the existence of small open reading frame (smORF)-encoded microproteins in mammals, their function remains to be…”
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2
Tau overexpression exacerbates neuropathology after repeated mild head impacts in male mice
Published in Neurobiology of disease (01-02-2020)“…Repeated mild traumatic brain injury (rmTBI) can lead to development of chronic traumatic encephalopathy (CTE), which is characterized by progressive…”
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Functional profiling of microtumors to identify cancer associated fibroblast-derived drug targets
Published in Oncotarget (21-11-2017)“…Recent advances in chemotherapeutics highlight the importance of molecularly-targeted perturbagens. Although these therapies typically address dysregulated…”
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In vitro and in silico characterization of the inhibition of Kir4.1 channels by aminoglycoside antibiotics
Published in British journal of pharmacology (01-10-2020)“…Background and Purpose Aminoglycoside antibiotics are positively charged molecules that are known to inhibit several ion channels. In this study, we have shown…”
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The anti-tumor drug 2-hydroxyoleic acid regulates the oncogenic potassium channel Kv10.1
Published in Beni-Suef University journal of basic and applied sciences (01-12-2023)“…Background 2-hydroxyoleic acid (2OHOA) is a synthetic fatty acid with antitumor properties that alters membrane composition and structure, which in turn…”
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Phytochemicals genistein and capsaicin modulate Kv2.1 channel gating
Published in Pharmacological reports (01-12-2017)“…Phytochemicals are a large group of plant-derived compounds that have a broad range of pharmacological effects. Some of these effects are derived from their…”
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Modulation of the voltage-gated potassium channel Kv2.1 by the anti-tumor alkylphospholipid perifosine
Published in Pharmacological reports (01-04-2016)“…The aim of the present study was to assess the effects of perifosine-a third generation alkylphospholipid analog with anti-tumor properties-on the activity of…”
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High‐throughput CRISPR‐mediated 3D enrichment platform for functional interrogation of chemotherapeutic resistance
Published in Biotechnology and bioengineering (01-08-2021)“…Cancer is a disease of somatic mutations. These cellular mutations compete to dominate their microenvironment and dictate the disease outcome. While a…”
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Chloroquine inhibits tumor-related Kv10.1 channel and decreases migration of MDA-MB-231 breast cancer cells in vitro
Published in European journal of pharmacology (15-07-2019)“…Chloroquine (CQ) is an old antimalarial drug currently being investigated for its anti-tumor properties. As chloroquine has been shown to inhibits several…”
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Modulation of Kv2.1 channels inactivation by curcumin
Published in Pharmacological reports (01-12-2015)“…The aim of the present study was to assess the effects of curcumin on the voltage-dependent Kv2.1 potassium channel. The whole-cell patch-clamp technique was…”
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