Search Results - "Moran, Michael F."

Refined RIP-seq protocol for epitranscriptome analysis with low input materials by Zeng, Yong, Wang, Shiyan, Gao, Shanshan, Soares, Fraser, Ahmed, Musadeqque, Guo, Haiyang, Wang, Miranda, Hua, Junjie Tony, Guan, Jiansheng, Moran, Michael F, Tsao, Ming Sound, He, Housheng Hansen

“…N6-Methyladenosine (m6A) accounts for approximately 0.2% to 0.6% of all adenosine in mammalian mRNA, representing the most abundant internal mRNA…”
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Global Proteomic Assessment of the Classical Protein-Tyrosine Phosphatome and “Redoxome” by Karisch, Robert, Fernandez, Minerva, Taylor, Paul, Virtanen, Carl, St-Germain, Jonathan R., Jin, Lily L., Harris, Isaac S., Mori, Jun, Mak, Tak W., Senis, Yotis A., Östman, Arne, Moran, Michael F., Neel, Benjamin G.

“…Protein-tyrosine phosphatases (PTPs), along with protein-tyrosine kinases, play key roles in cellular signaling. All Class I PTPs contain an essential active…”
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A feed forward loop enforces YAP/TAZ signaling during tumorigenesis by Gill, Mandeep K., Christova, Tania, Zhang, Ying Y., Gregorieff, Alex, Zhang, Liang, Narimatsu, Masahiro, Song, Siyuan, Xiong, Shawn, Couzens, Amber L., Tong, Jiefei, Krieger, Jonathan R., Moran, Michael F., Zlotta, Alexandre R., van der Kwast, Theodorus H., Gingras, Anne-Claude, Sicheri, Frank, Wrana, Jeffrey L., Attisano, Liliana

“…In most solid tumors, the Hippo pathway is inactivated through poorly understood mechanisms that result in the activation of the transcriptional regulators,…”
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Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis by Wang, Siyu, Juan, Jiaxiang, Zhang, Zubin, Du, Yanyun, Xu, Yujia, Tong, Jiefei, Cao, Biyin, Moran, Michael F, Zeng, Yuanying, Mao, Xinliang

“…The deubiquitinase USP5 stabilizes c-Maf, a key transcription factor in multiple myeloma (MM), but the mechanisms and significance are unclear. In the present…”
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Reciprocal stabilization of ABL and TAZ regulates osteoblastogenesis through transcription factor RUNX2 by Matsumoto, Yoshinori, La Rose, Jose, Kent, Oliver A, Wagner, Melany J, Narimatsu, Masahiro, Levy, Aaron D, Omar, Mitchell H, Tong, Jiefei, Krieger, Jonathan R, Riggs, Emily, Storozhuk, Yaryna, Pasquale, Julia, Ventura, Manuela, Yeganeh, Behzad, Post, Martin, Moran, Michael F, Grynpas, Marc D, Wrana, Jeffrey L, Superti-Furga, Giulio, Koleske, Anthony J, Pendergast, Ann Marie, Rottapel, Robert

“…Cellular identity in metazoan organisms is frequently established through lineage-specifying transcription factors, which control their own expression through…”
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Tankyrase represses autoinflammation through the attenuation of TLR2 signaling by Matsumoto, Yoshinori, Dimitriou, Ioannis D, La Rose, Jose, Lim, Melissa, Camilleri, Susan, Law, Napoleon, Adissu, Hibret A, Tong, Jiefei, Moran, Michael F, Chruscinski, Andrzej, He, Fang, Asano, Yosuke, Katsuyama, Takayuki, Sada, Ken-Ei, Wada, Jun, Rottapel, Robert

“…Dysregulation of Toll-like receptor (TLR) signaling contributes to the pathogenesis of autoimmune diseases. Here, we provide genetic evidence that tankyrase, a…”
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Cancer proteome and metabolite changes linked to SHMT2 by Tong, Jiefei, Krieger, Jonathan R, Taylor, Paul, Bagshaw, Rick, Kang, Jae, Jeedigunta, Swathi, Wybenga-Groot, Leanne E, Zhang, Wen, Badr, Heba, Mirhadi, Shideh, Pham, Nhu-An, Coyaud, Étienne, Yu, Man, Li, Ming, Cabanero, Michael, Raught, Brian, Maynes, Jason T, Hawkins, Cynthia, Tsao, Ming Sound, Moran, Michael F

“…Serine hydroxymethyltransferase 2 (SHMT2) converts serine plus tetrahydrofolate (THF) into glycine plus methylene-THF and is upregulated at the protein level…”
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The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation by Xie, Jinglin L., Qin, Longguang, Miao, Zhengqiang, Grys, Ben T., Diaz, Jacinto De La Cruz, Ting, Kenneth, Krieger, Jonathan R., Tong, Jiefei, Tan, Kaeling, Leach, Michelle D., Ketela, Troy, Moran, Michael F., Krysan, Damian J., Boone, Charles, Andrews, Brenda J., Selmecki, Anna, Ho Wong, Koon, Robbins, Nicole, Cowen, Leah E.

“…The capacity to coordinate environmental sensing with initiation of cellular responses underpins microbial survival and is crucial for virulence and stress…”
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The human phosphotyrosine signaling network: evolution and hotspots of hijacking in cancer by Li, Lei, Tibiche, Chabane, Fu, Cong, Kaneko, Tomonori, Moran, Michael F, Schiller, Martin R, Li, Shawn Shun-Cheng, Wang, Edwin

“…Phosphotyrosine (pTyr) signaling, which plays a central role in cell-cell and cell-environment interactions, has been considered to be an evolutionary…”
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Activation of mitogen-activated protein kinase signaling and development of papillary thyroid carcinoma in thyroid-stimulating hormone receptor D633H knockin mice by Eszlinger, Markus, Stephenson, Alexandra, Mirhadi, Shideh, Patyra, Konrad, Moran, Michael F, Khalil, Moosa, Kero, Jukka, Paschke, Ralf

“…Nonautoimmune hyperthyroidism (NAH) is rare and occurs due to a constitutively activating thyroid stimulating hormone receptor (TSHR) mutation. In contrast to…”
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Protein‐phosphotyrosine proteome profiling by superbinder‐SH2 domain affinity purification mass spectrometry, sSH2‐AP‐MS by Tong, Jiefei, Cao, Biyin, Martyn, Gregory D., Krieger, Jonathan R., Taylor, Paul, Yates, Bradley, Sidhu, Sachdev S., Li, Shawn S. C., Mao, Xinliang, Moran, Michael F.

“…Recently, “superbinder” SH2 domain variants with three amino acid substitutions (sSH2) were reported to have 100‐fold or greater affinity for…”
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The ubiquitin-conjugating enzyme UBE2O modulates c-Maf stability and induces myeloma cell apoptosis by Xu, Yujia, Zhang, Zubin, Li, Jie, Tong, Jiefei, Cao, Biyin, Taylor, Paul, Tang, Xiaowen, Wu, Depei, Moran, Michael F, Zeng, Yuanying, Mao, Xinliang

“…UBE2O is proposed as a ubiquitin-conjugating enzyme, but its function was largely unknown. Mass spectrometry was applied to identify c-Maf…”
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Integrated analysis of proteome, phosphotyrosine‐proteome, tyrosine‐kinome, and tyrosine‐phosphatome in acute myeloid leukemia by Tong, Jiefei, Helmy, Mohamed, Cavalli, Florence M. G., Jin, Lily, St‐Germain, Jonathan, Karisch, Robert, Taylor, Paul, Minden, Mark D., Taylor, Michael D., Neel, Benjamin G., Bader, Gary D., Moran, Michael F.

“…Reversible protein‐tyrosine phosphorylation is catalyzed by the antagonistic actions of protein‐tyrosine kinases (PTKs) and phosphatases (PTPs), and represents…”
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Proteomic profiles of human lung adeno and squamous cell carcinoma using super-SILAC and label-free quantification approaches by Zhang, Wen, Wei, Yuhong, Ignatchenko, Vladimir, Li, Lei, Sakashita, Shingo, Pham, Nhu-An, Taylor, Paul, Tsao, Ming Sound, Kislinger, Thomas, Moran, Michael F.

“…Nonsmall cell lung cancer (NSCLC) accounts for 85% of lung cancers, and is subdivided into two major histological subtypes: adenocarcinoma (ADC) and squamous…”
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Prediction of LC-MS/MS Properties of Peptides from Sequence by Deep Learning[S] by Guan, Shenheng, Moran, Michael F., Ma, Bin

“…Indexed retention times (iRT), MS1 (the first level of mass analysis) or survey scan charge state distributions, and sequence ion intensities of MSMS (tandom…”
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The ShcD signaling adaptor facilitates ligand-independent phosphorylation of the EGF receptor by Wills, Melanie K B, Tong, Jiefei, Tremblay, Sylvie L, Moran, Michael F, Jones, Nina

“…Proto-oncogenic Src homology and collagen (Shc) proteins have been considered archetypal adaptors of epidermal growth factor receptor (EGFR)-mediated…”
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Distinct Regulation of Transmitter Release at the Drosophila NMJ by Different Isoforms of nemy by Knight, David, Iliadi, Konstantin G, Iliadi, Natalia, Wilk, Ronit, Hu, Jack, Krause, Henry M, Taylor, Paul, Moran, Michael F, Boulianne, Gabrielle L

“…Synaptic transmission is highly plastic and subject to regulation by a wide variety of neuromodulators and neuropeptides. In the present study, we have…”
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Measurement of Protein Phosphorylation Stoichiometry by Selected Reaction Monitoring Mass Spectrometry by Jin, Lily L, Tong, Jiefei, Prakash, Amol, Peterman, Scott M, St-Germain, Jonathan R, Taylor, Paul, Trudel, Suzanne, Moran, Michael F

“…The stoichiometry of protein phosphorylation at specific amino acid sites may be used to infer on the significance of the modification, and its biological…”
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Proteomic Analysis of the Epidermal Growth Factor Receptor (EGFR) Interactome and Post-translational Modifications Associated with Receptor Endocytosis in Response to EGF and Stress by Tong, Jiefei, Taylor, Paul, Moran, Michael F.

“…Aberrant expression, activation, and stabilization of epidermal growth factor receptor (EGFR) are causally associated with several human cancers…”
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Odin (ANKS1A) modulates EGF receptor recycling and stability by Tong, Jiefei, Sydorskyy, Yaroslav, St-Germain, Jonathan R, Taylor, Paul, Tsao, Ming S, Moran, Michael F

“…The ANKS1A gene product, also known as Odin, was first identified as a tyrosine-phosphorylated component of the epidermal growth factor receptor network. Here…”
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