Search Results - "Moran, Gary P."

The Microbiome of Potentially Malignant Oral Leukoplakia Exhibits Enrichment for Fusobacterium, Leptotrichia, Campylobacter , and Rothia Species by Amer, Abdrazak, Galvin, Sheila, Healy, Claire M, Moran, Gary P

“…Oral leukoplakia presents as a white patch on the oral mucosa and is recognized as having significant malignant potential. Although colonization of these…”
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Deletion of the Candida albicans TLO gene family results in alterations in membrane sterol composition and fluconazole tolerance by O'Connor-Moneley, James, Fletcher, Jessica, Bean, Cody, Parker, Josie, Kelly, Steven L, Moran, Gary P, Sullivan, Derek J

“…Development of resistance and tolerance to antifungal drugs in Candida albicans can compromise treatment of infections caused by this pathogenic yeast species…”
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Fusobacterium nucleatum induces invasive growth and angiogenic responses in malignant oral keratinocytes that are cell line- and bacterial strain-specific by Selvaraj, Ajith, McManus, Gavin, Healy, Claire M, Moran, Gary P

“…is an anaerobic commensal of the oral cavity recently reported to be associated with cancers of the gastrointestinal tract and oral squamous cell carcinoma…”
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Editorial: The Human Microbiome and Cancer by Moran, Gary P., Al-Hebshi, Nezar

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Smoking, tooth loss and oral hygiene practices have significant and site-specific impacts on the microbiome of oral mucosal surfaces: a cross-sectional study by Galvin, Sheila, Anishchuk, Sviatlana, Healy, Claire M., Moran, Gary P.

“…We investigated bacterial colonisation patterns of healthy mucosa (buccal, tongue, palate and floor of mouth) in a cohort of adults in order to determine how…”
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The Oral Microbiome in Pediatric IBD: A Source of Pathobionts or Biomarkers? by Elmaghrawy, Khalid, Hussey, Séamus, Moran, Gary P

“…The oral cavity is continuous with the gastrointestinal tract and in children, oral health may be closely linked with the overall health of the GI tract. In…”
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Deletion of the Candida albicans TLO gene family using CRISPR-Cas9 mutagenesis allows characterisation of functional differences in α-, β- and γ- TLO gene function by Fletcher, Jessica, O'Connor-Moneley, James, Frawley, Dean, Flanagan, Peter R, Alaalm, Leenah, Menendez-Manjon, Pilar, Estevez, Samuel Vega, Hendricks, Shane, Woodruff, Andrew L, Buscaino, Alessia, Anderson, Matthew Z, Sullivan, Derek J, Moran, Gary P

“…The Candida albicans genome contains between ten and fifteen distinct TLO genes that all encode a Med2 subunit of Mediator. In order to investigate the…”
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Comparative Genomics and the Evolution of Pathogenicity in Human Pathogenic Fungi by Moran, Gary P, Coleman, David C, Sullivan, Derek J

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Influence of site and smoking on malignant transformation in the oral cavity: Is the microbiome the missing link? by Galvin, Sheila, Moran, Gary P, Healy, Claire M

“…The tongue and floor of the mouth are high-risk sites for oral squamous cell carcinoma (OSCC), while smoking is its most significant risk factor. Recently,…”
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Expansion of the TLO gene family enhances the virulence of Candida species by Flanagan, Peter R, Fletcher, Jessica, Boyle, Hannah, Sulea, Razvan, Moran, Gary P, Sullivan, Derek J

“…The TLO genes are a family of subtelomeric ORFs in the fungal pathogens Candida albicans and C. dubliniensis encoding a subunit of the Mediator complex…”
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Stress- and metabolic responses of Candida albicans require Tor1 kinase N-terminal HEAT repeats by Qi, Wanjun, Acosta-Zaldivar, Maikel, Flanagan, Peter R, Liu, Ning-Ning, Jani, Niketa, Fierro, José F, Andrés, María T, Moran, Gary P, Köhler, Julia R

“…Whether to commit limited cellular resources toward growth and proliferation, or toward survival and stress responses, is an essential determination made by…”
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Acetaldehyde production by Rothia mucilaginosa isolates from patients with oral leukoplakia by Amer, Abdrazak, Whelan, Aine, Al-Hebshi, Nezar N., Healy, Claire M., Moran, Gary P.

“…Rothia mucilaginosa has been found at high abundance on oral leukoplakia (OLK). The ability of clinical isolates to produce acetaldehyde (ACH) from ethanol has…”
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Response of Extraintestinal Pathogenic Escherichia coli to Human Serum Reveals a Protective Role for Rcs-Regulated Exopolysaccharide Colanic Acid by Miajlovic, Helen, Cooke, Niamh M, Moran, Gary P, Rogers, Thomas R F, Smith, Stephen G

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The Histone-Deacetylase-Inhibitor Suberoylanilide Hydroxamic Acid Promotes Dental Pulp Repair Mechanisms Through Modulation of Matrix Metalloproteinase-13 Activity by Duncan, Henry F., Smith, Anthony J., Fleming, Garry J. P., Partridge, Nicola C., Shimizu, Emi, Moran, Gary P., Cooper, Paul R.

“…Direct application of histone‐deacetylase‐inhibitors (HDACis) to dental pulp cells (DPCs) induces chromatin changes, promoting gene expression and…”
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The Candida albicans-specific gene EED1 encodes a key regulator of hyphal extension by Martin, Ronny, Moran, Gary P, Jacobsen, Ilse D, Heyken, Antje, Domey, Jenny, Sullivan, Derek J, Kurzai, Oliver, Hube, Bernhard

“…The extension of germ tubes into elongated hyphae by Candida albicans is essential for damage of host cells. The C. albicans-specific gene EED1 plays a crucial…”
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Candida albicans versus Candida dubliniensis: Why Is C. albicans More Pathogenic? by Moran, Gary P., Sullivan, Derek J., Coleman, David C.

“…Candida albicans and Candida dubliniensis are highly related pathogenic yeast species. However, C. albicans is far more prevalent in human infection and has…”
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Amplification of TLO Mediator Subunit Genes Facilitate Filamentous Growth in Candida Spp by Liu, Zhongle, Moran, Gary P, Sullivan, Derek J, MacCallum, Donna M, Myers, Lawrence C

“…Filamentous growth is a hallmark of C. albicans pathogenicity compared to less-virulent ascomycetes. A multitude of transcription factors regulate filamentous…”
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Telomeric ORFs (TLOs) in Candida spp. Encode mediator subunits that regulate distinct virulence traits by Haran, John, Boyle, Hannah, Hokamp, Karsten, Yeomans, Tim, Liu, Zhongle, Church, Michael, Fleming, Alastair B, Anderson, Matthew Z, Berman, Judith, Myers, Lawrence C, Sullivan, Derek J, Moran, Gary P

“…The TLO genes are a family of telomere-associated ORFs in the fungal pathogens Candida albicans and C. dubliniensis that encode a subunit of the Mediator…”
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Telomeric ORFS in Candida albicans: does mediator tail wag the yeast? by Sullivan, Derek J, Berman, Judith, Myers, Lawrence C, Moran, Gary P

“…  Recent analysis of Mediator functions in C. albicans have shown that this complex plays an important role in regulating many virulence-associated traits such…”
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Comparative Transcript Profiling of Candida albicans and Candida dubliniensis Identifies SFL2, a C. albicans Gene Required for Virulence in a Reconstituted Epithelial Infection Model by Spiering, Martin J., Moran, Gary P., Chauvel, Murielle, MacCallum, Donna M., Higgins, Judy, Hokamp, Karsten, Yeomans, Tim, d'Enfert, Christophe, Coleman, David C., Sullivan, Derek J.

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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