Search Results - "Morales, Tony H."

Discovery of pyrrolopyrimidine inhibitors of Akt by Blake, James F., Kallan, Nicholas C., Xiao, Dengming, Xu, Rui, Bencsik, Josef R., Skelton, Nicholas J., Spencer, Keith L., Mitchell, Ian S., Woessner, Richard D., Gloor, Susan L., Risom, Tyler, Gross, Stefan D., Martinson, Matthew, Morales, Tony H., Vigers, Guy P.A., Brandhuber, Barbara J.

“…The discovery and optimization of a series of pyrrolopyrimidine based protein kinase B (Pkb/Akt) inhibitors discovered via HTS and structure based drug design…”
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Discovery and SAR of spirochromane Akt inhibitors by Kallan, Nicholas C., Spencer, Keith L., Blake, James F., Xu, Rui, Heizer, Justin, Bencsik, Josef R., Mitchell, Ian S., Gloor, Susan L., Martinson, Matthew, Risom, Tyler, Gross, Stefan D., Morales, Tony H., Wu, Wen-I, Vigers, Guy P.A., Brandhuber, Barbara J., Skelton, Nicholas J.

“…A novel series of spirochromane pan-Akt inhibitors is reported. SAR optimization furnished compounds with improved enzyme potencies and excellent selectivity…”
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A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors by Drilon, Alexander, Nagasubramanian, Ramamoorthy, Blake, James F, Ku, Nora, Tuch, Brian B, Ebata, Kevin, Smith, Steve, Lauriault, Veronique, Kolakowski, Gabrielle R, Brandhuber, Barbara J, Larsen, Paul D, Bouhana, Karyn S, Winski, Shannon L, Hamor, Robyn, Wu, Wen-I, Parker, Andrew, Morales, Tony H, Sullivan, Francis X, DeWolf, Walter E, Wollenberg, Lance A, Gordon, Paul R, Douglas-Lindsay, Dorothea N, Scaltriti, Maurizio, Benayed, Ryma, Raj, Sandeep, Hanusch, Bethany, Schram, Alison M, Jonsson, Philip, Berger, Michael F, Hechtman, Jaclyn F, Taylor, Barry S, Andrews, Steve, Rothenberg, S Michael, Hyman, David M

“…Larotrectinib, a selective TRK tyrosine kinase inhibitor (TKI), has demonstrated histology-agnostic efficacy in patients with TRK fusion-positive cancers…”
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Preclinical characterization of pirtobrutinib, a highly selective, noncovalent (reversible) BTK inhibitor by Gomez, Eliana B., Ebata, Kevin, Randeria, Hetal S., Rosendahl, Mary S., Cedervall, E. Peder, Morales, Tony H., Hanson, Lauren M., Brown, Nicholas E., Gong, Xueqian, Stephens, Jennifer, Wu, Wenjuan, Lippincott, Isabel, Ku, Karin S., Walgren, Richard A., Abada, Paolo B., Ballard, Joshua A., Allerston, Charles K., Brandhuber, Barbara J.

“…•Pirtobrutinib is a potent, noncovalent (reversible), highly selective inhibitor of BTK and C481-mutant BTK.•Pirtobrutinib is efficacious in B-cell models…”
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An ATP-site on-off switch that restricts phosphatase accessibility of Akt by Lin, Kui, Lin, Jie, Wu, Wen-I, Ballard, Joshua, Lee, Brian B, Gloor, Susan L, Vigers, Guy P A, Morales, Tony H, Friedman, Lori S, Skelton, Nicholas, Brandhuber, Barbara J

“…The protein serine-threonine kinase Akt undergoes a substantial conformational change upon activation, which is induced by the phosphorylation of two critical…”
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Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA by Xu, Rui, Banka, Anna, Blake, James F., Mitchell, Ian S., Wallace, Eli M., Bencsik, Josef R., Kallan, Nicholas C., Spencer, Keith L., Gloor, Susan L., Martinson, Matthew, Risom, Tyler, Gross, Stefan D., Morales, Tony H., Wu, Wen-I, Vigers, Guy P.A., Brandhuber, Barbara J., Skelton, Nicholas J.

“…We describe the design and synthesis of novel bicyclic spiro sulfonamides as potent Akt inhibitors. Through structure-based rational design, we have…”
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Cloning and preliminary characterization of a novel cuticular antigen from the filarial parasite Dirofilaria immitis by Tsuji, Naotoshi, Morales, Tony H, Ozols, Victor V, Carmody, Aaron B, Chandrashekar, Ramaswamy

“…We have described here the cloning and partial characterization of a cDNA encoding a cuticular antigen of Dirofilaria immitis. A 48-h third-stage larval D…”
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Pirtobrutinib preclinical characterization: a highly selective, non-covalent (reversible) BTK inhibitor by Gomez, Eliana B, Ebata, Kevin, Randeria, Hetal S, Rosendahl, Mary S, Cedervall, Ernst Peder, Morales, Tony H, Hanson, Lauren M, Brown, Nicholas E, Gong, Xueqian, Stephens, Jennifer Rachelle, Wu, Wenjuan, Lippincott, Isabel, Ku, Karin S., Walgren, Richard A, Abada, Paolo B, Ballard, Joshua A, Allerston, Charles K, Brandhuber, Barbara J

“…Bruton tyrosine kinase (BTK), a nonreceptor tyrosine kinase, is a major therapeutic target for B-cell driven malignancies. However, approved covalent BTK…”
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The formation of mitochondrial ribonucleoprotein complexes involving guide RNA molecules in Trypanosoma brucei by Goringer, H. Ulrich, Koslowsky, Donna J., Morales, Tony H., Stuart, Kenneth

“…Transcripts from mitochondrial (maxicircle) genes of kinetoplastid organisms undergo RNA editing characterized by a series of reactions that insert and delete…”
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Identification of an asparagine amidohydrolase from the filarial parasite Dirofilaria immitis by Tsuji, Naotoshi, Morales, Tony H, V. Ozols, Victor, Carmody, Aaron B, Chandrashekar, Ramaswamy

“…The nematode cuticle is a complex extracellular structure which is secreted by an underlying syncytium of hypodermal cells. Recent studies have demonstrated…”
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Abstract 2780: Unique pharmacodynamic properties conferred by differential binding to BTK, pirtobrutinib vs covalent inhibitors by Ballard, Joshua A., Ebata, Kevin, Randeria, Hetal S., Tinline, Garrett, Lee, Thomas, Hanson, Lauren M., Latham, John A., Cedervall, E. Peder, Chong, Jenny, Valle, Kyle B. Del, Collins, Bernard C., Morales, Tony H., Benedict, Thomas C., Schureck, Marc A., Bender, Ethan T., Mendoza, Christopher, Molina, David, Nakamoto, Meagan, Shiah, Hsiao-Chiao, Xu, Hao, Espada, Alfonso, Cano, Leticia, Allerston, Charles K., Schnier, Paul, Brandhuber, Barbara J.

“…Abstract Covalent Bruton tyrosine kinase inhibitors (cBTKi) have transformed the treatment of B cell malignancies. Despite the efficacy of cBTKi, treatment…”
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An Abnormal Pattern of Embryonic Development during Early Pregnancy in Aging Rats1 by Day, Jonathan R., La Polt, Philip S., Morales, Tony H., Lu, John K. H.

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In vitro guide RNA/mRNA chimaera formation in Trypanosoma bruceiRNA editing by Koslowsky, Donna J., Göringer, H. Ulrich, Morales, Tony H., Stuart, Kenneth

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Identification of an asparagine amidohydrolase from the filarial parasite Dirofilaria immitis1The nucleotide sequence reported in this paper has been submitted to the GenBank database with accession number AF116552.1 by Tsuji, Naotoshi, Morales, Tony H, V. Ozols, Victor, Carmody, Aaron B, Chandrashekar, Ramaswamy

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Molecular characterization of a calcium-binding protein from the filarial parasite Dirofilaria immitis by Tsuji, Naotoshi, Morales, TonyH, Ozols, VictorV, Carmody, AaronB, Chandrashekar, Ramaswamy

“…A full length D. immitis cDNA (nDiCal) encoding a protein with significant similarity to the calreticulin protein family was isolated from a 6-day fourth-stage…”
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Structural organization of the maxicircle variable region of Trypanosoma brucei: identification of potential replication origins and topoisomerase II binding sites by Myler, P.J, Glick, D, Feagin, J.E, Morales, T.H, Stuart, K.D

“…The maxicircle of the parasitic protozoan Trypanosoma brucei, one component of the mitochondrial genome, has size differences among isolates that localize to…”
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Genomic and transcriptional linkage of the genes for calmodulin, EF-hand 5 protein, and ubiquitin extension protein 52 in Trypanosoma brucei by Wong, S, Morales, T H, Neigel, J E, Campbell, D A

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Male Stimulation of Luteinizing Hormone Surge, Progesterone SeCretion and Ovulation in Spontaneously Persistent-Estrous, Aging Rats1 by Day, Jonathan R., Morales, Tony H., Lu, John K.H.

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In vitro guide RNA/mRNA chimaera formation in Trypanosoma brucei RNA editing by Koslowsky, Donna J, Göringer, H. Ulrich, Morales, Tony H, Stuart, Kenneth

“…The post-transcriptional processing of various mitochondrial transcripts in kinetoplastids, kRNA editing, adds and removes uridines, producing mature messenger…”
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Genomic and Transcriptional Linkage of the Genes for Calmodulin, EF-Hand 5 Protein, and Ubiquitin Extension Protein 52 in Trypanosoma brucei by Wong, Sandy, Morales, Tony H., Neigel, Joseph E., Campbell, David A.

“…We report genomic linkage of a pair of tandem, identical ubiquitin-extension protein 52 (EP52) genes, a novel EF-hand superfamily member gene (EFH5), and the…”
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