Search Results - "Morales, Aizea Kastresana"

MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments by Welsh, Joshua A., Van Der Pol, Edwin, Arkesteijn, Ger J.A., Bremer, Michel, Brisson, Alain, Coumans, Frank, Dignat-George, Françoise, Duggan, Erika, Ghiran, Ionita, Giebel, Bernd, Görgens, André, Hendrix, An, Lacroix, Romaric, Lannigan, Joanne, Libregts, Sten F.W.M., Lozano-Andrés, Estefanía, Morales-Kastresana, Aizea, Robert, Stephane, De Rond, Leonie, Tertel, Tobias, Tigges, John, De Wever, Olivier, Yan, Xiaomei, Nieuwland, Rienk, Wauben, Marca H.M., Nolan, John P., Jones, Jennifer C.

“…Extracellular vesicles (EVs) are small, heterogeneous and difficult to measure. Flow cytometry (FC) is a key technology for the measurement of individual…”
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Scalable, cGMP-compatible purification of extracellular vesicles carrying bioactive human heterodimeric IL-15/lactadherin complexes by Watson, Dionysios C., Yung, Bryant C., Bergamaschi, Cristina, Chowdhury, Bhabadeb, Bear, Jenifer, Stellas, Dimitris, Morales-Kastresana, Aizea, Jones, Jennifer C., Felber, Barbara K., Chen, Xiaoyuan, Pavlakis, George N.

“…The development of extracellular vesicles (EV) for therapeutic applications is contingent upon the establishment of reproducible, scalable, and high-throughput…”
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High-fidelity detection and sorting of nanoscale vesicles in viral disease and cancer by Morales-Kastresana, Aizea, Musich, Thomas A., Welsh, Joshua A., Telford, William, Demberg, Thorsten, Wood, James C. S., Bigos, Marty, Ross, Carley D., Kachynski, Aliaksander, Dean, Alan, Felton, Edward J., Van Dyke, Jonathan, Tigges, John, Toxavidis, Vasilis, Parks, David R., Overton, W. Roy, Kesarwala, Aparna H., Freeman, Gordon J., Rosner, Ariel, Perfetto, Stephen P., Pasquet, Lise, Terabe, Masaki, McKinnon, Katherine, Kapoor, Veena, Trepel, Jane B., Puri, Anu, Kobayashi, Hisataka, Yung, Bryant, Chen, Xiaoyuan, Guion, Peter, Choyke, Peter, Knox, Susan J., Ghiran, Ionita, Robert-Guroff, Marjorie, Berzofsky, Jay A., Jones, Jennifer C.

“…Biological nanoparticles, including viruses and extracellular vesicles (EVs), are of interest to many fields of medicine as biomarkers and mediators of or…”
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Efficient production and enhanced tumor delivery of engineered extracellular vesicles by Watson, Dionysios C, Bayik, Defne, Srivatsan, Avinash, Bergamaschi, Cristina, Valentin, Antonio, Niu, Gang, Bear, Jenifer, Monninger, Mitchell, Sun, Mei, Morales-Kastresana, Aizea, Jones, Jennifer C, Felber, Barbara K, Chen, Xiaoyuan, Gursel, Ihsan, Pavlakis, George N

“…Abstract Extracellular vesicles (EV), including exosomes and microvesicles, are nano-sized intercellular communication vehicles that participate in a multitude…”
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Labeling Extracellular Vesicles for Nanoscale Flow Cytometry by Morales-Kastresana, Aizea, Telford, Bill, Musich, Thomas A., McKinnon, Katherine, Clayborne, Cassandra, Braig, Zach, Rosner, Ari, Demberg, Thorsten, Watson, Dionysios C., Karpova, Tatiana S., Freeman, Gordon J., DeKruyff, Rosemarie H., Pavlakis, George N., Terabe, Masaki, Robert-Guroff, Marjorie, Berzofsky, Jay A., Jones, Jennifer C.

“…Extracellular vesicles (EVs), including exosomes and microvesicles, are 30–800 nm vesicles that are released by most cell types, as biological packages for…”
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Molecular Pathways: Hypoxia Response in Immune Cells Fighting or Promoting Cancer by PALAZON, Asis, ARAGONES, Julián, MORALES-KASTRESANA, Aizea, DE LANDAZURI, Manuel Ortiz, MELERO, Ignacio

“…Both malignant and stromal components in tumors are influenced by the physiologic conditions of the microenvironment. Hypoxia is a prominent feature of solid…”
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Focusing and sustaining the antitumor CTL effector killer response by agonist anti-CD137 mAb by Weigelin, Bettina, Elixabet Bolaños, Alvaro Teijeira, Ivan Martinez-Forero, Sara Labiano, Arantza Azpilikueta, Aizea Morales-Kastresana, Josñé I. Quetglas, Esther Wagena, Alfonso Rodrñéíguez Sñéíánchez-Paulete, Lieping Chen, Peter Friedl, Ignacio Melero

“…Cancer immunotherapy is undergoing significant progress due to recent clinical successes by refined adoptive T-cell transfer and immunostimulatory monoclonal…”
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Intratumorally delivered formulation, INT230-6, containing potent anticancer agents induces protective T cell immunity and memory by Bloom, Anja C., Bender, Lewis H., Tiwary, Shweta, Pasquet, Lise, Clark, Katharine, Jiang, Tianbo, Xia, Zheng, Morales-Kastresana, Aizea, Jones, Jennifer C., Walters, Ian, Terabe, Masaki, Berzofsky, Jay A.

“…The benefits of anti-cancer agents extend beyond direct tumor killing. One aspect of cell death is the potential to release antigens that initiate adaptive…”
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Innate functions of immunoglobulin M lessen liver gene transfer with helper-dependent adenovirus by Unzu, Carmen, Melero, Ignacio, Morales-Kastresana, Aizea, Sampedro, Ana, Serrano-Mendioroz, Irantzu, Azpilikueta, Arantza, Ochoa, María Carmen, Dubrot, Juan, Martínez-Ansó, Eduardo, Fontanellas, Antonio

“…The immune system poses obstacles to viral vectors, even in the first administration to preimmunized hosts. We have observed that the livers of B…”
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Dendritic cells take up and present antigens from viable and apoptotic polymorphonuclear leukocytes by Alfaro, Carlos, Suarez, Natalia, Oñate, Carmen, Perez-Gracia, Jose L, Martinez-Forero, Ivan, Hervas-Stubbs, Sandra, Rodriguez, Inmaculada, Perez, Guiomar, Bolaños, Elixabet, Palazon, Asis, Sanmamed, Miguel Fernandez de, Morales-Kastresana, Aizea, Gonzalez, Alvaro, Melero, Ignacio

“…Dendritic cells (DC) are endowed with the ability to cross-present antigens from other cell types to cognate T cells. DC are poised to meet polymorphonuclear…”
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Liver gene transfer of interkeukin-15 constructs that become part of circulating high density lipoproteins for immunotherapy by Ochoa, Maria C, Fioravanti, Jessica, Duitman, Erwin H, Medina-Echeverz, Jose, Palazon, Asis, Arina, Ainhoa, Dubrot, Juan, Alfaro, Carlos, Morales-Kastresana, Aizea, Murillo, Oihana, Hervas-Stubbs, Sandra, Prieto, Jesus, Berraondo, Pedro, Melero, Ignacio

“…Apolipoprotein A-I (Apo A-I) is a major component of high density lipoproteins (HDL) that transport cholesterol in circulation. We have constructed an…”
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Synergistic effects of CTLA‐4 blockade with tremelimumab and elimination of regulatory T lymphocytes in vitro and in vivo by Suarez, Natalia, Alfaro, Carlos, Dubrot, Juan, Palazon, Asis, Bolaños, Elixabet, Erro, Lorena, Hervas‐Stubbs, Sandra, Martinez‐Forero, Ivan, Morales‐Kastresana, Aizea, Martin‐Algarra, Salvador, Sangro, Bruno, Lecanda, Fernando, Perez‐Gracia, Jose L., Gonzalez, Alvaro, Melero, Ignacio

“…Anti‐CTLA‐4 monoclonal antibodies (mAb) that block the interaction of CTLA‐4 with CD80 and CD86 such as tremelimumab and ipilimumab are currently being tested…”
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Flow Cytometric Analysis of Extracellular Vesicles by Morales-Kastresana, Aizea, Jones, Jennifer C

“…To analyze EVs with conventional flow cytometers, most researchers will find it necessary to bind EVs to beads that are large enough to be individually…”
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Agonist Antibodies to TNFR Molecules That Costimulate T and NK Cells by MELERO, Ignacio, HIRSCHHORN-CYMERMAN, Daniel, MORALES-KASTRESANA, Aizea, SANMAMED, Miguel F, WOLCHOK, Jedd D

“…Therapy for cancer can be achieved by artificially stimulating antitumor T and natural killer (NK) lymphocytes with agonist monoclonal antibodies (mAb). T and…”
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Cancer Immunotherapy with Immunomodulatory Anti-CD137 and Anti-PD-1 Monoclonal Antibodies Requires BATF3-Dependent Dendritic Cells by Sánchez-Paulete, Alfonso R, Cueto, Francisco J, Martínez-López, María, Labiano, Sara, Morales-Kastresana, Aizea, Rodríguez-Ruiz, María E, Jure-Kunkel, Maria, Azpilikueta, Arantza, Aznar, M Angela, Quetglas, José I, Sancho, David, Melero, Ignacio

“…Weak and ineffective antitumor cytotoxic T lymphocyte (CTL) responses can be rescued by immunomodulatory mAbs targeting PD-1 or CD137. Using Batf3(-/-) mice,…”
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The PD-L1/4-1BB Bispecific Antibody-Anticalin Fusion Protein PRS-344/S095012 Elicits Strong T-Cell Stimulation in a Tumor-Localized Manner by Peper-Gabriel, Janet K, Pavlidou, Marina, Pattarini, Lucia, Morales-Kastresana, Aizea, Jaquin, Thomas J, Gallou, Catherine, Hansbauer, Eva-Maria, Richter, Marleen, Lelievre, Helene, Scholer-Dahirel, Alix, Bossenmaier, Birgit, Sancerne, Celine, Riviere, Matthieu, Grandclaudon, Maximilien, Zettl, Markus, Bel Aiba, Rachida S, Rothe, Christine, Blanc, Veronique, Olwill, Shane A

“…While patients responding to checkpoint blockade often achieve remarkable clinical responses, there is still significant unmet need due to resistant or…”
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Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2-/-IL2Rγnull Immunodeficient Mice by Sanmamed, Miguel F, Rodriguez, Inmaculada, Schalper, Kurt A, Oñate, Carmen, Azpilikueta, Arantza, Rodriguez-Ruiz, Maria E, Morales-Kastresana, Aizea, Labiano, Sara, Pérez-Gracia, Jose L, Martín-Algarra, Salvador, Alfaro, Carlos, Mazzolini, Guillermo, Sarno, Francesca, Hidalgo, Manuel, Korman, Alan J, Jure-Kunkel, Maria, Melero, Ignacio

“…A current pressing need in cancer immunology is the development of preclinical model systems that are immunocompetent for the study of human tumors. Here, we…”
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Combined Immunostimulatory Monoclonal Antibodies Extend Survival in an Aggressive Transgenic Hepatocellular Carcinoma Mouse Model by MORALES-KASTRESANA, Aizea, SANMAMED, Miguel F, AZPILIKUETA, Arantza, BOLANOS, Elixabet, JURE-KUNKEL, Maria, GÜTGEMANN, Ines, MELERO, Ignacio, RODRIGUEZ, Inmaculada, PALAZON, Asis, MARTINEZ-FORERO, Ivan, LABIANO, Sara, HERVAS-STUBBS, Sandra, SANGRO, Bruno, OCHOA, Carmen, ROUZAUT, Ana

“…Immunostimulatory monoclonal antibodies (ISmAb) that unleash antitumor immune responses are showing efficacy in cancer clinical trials. Anti-B7-H1 (PD-L1)…”
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Abstract LB135: Simultaneous costimulatory T-cell engagement and checkpoint inhibition by PRS-344/S095012, a PD-L1/4-1BB bispecific compound for tumor localized activation of the immune system by Morales-Kastresana, Aizea, Pavlidou, Marina, Peper, Janet, Pattarini, Lucia, Barthels, Christian, Hansbauer, Eva-Maria, Aiba, Rachida Bel, Bossenmaier, Birgit, Scholer-Dahirel, Alix, Jaquin, Thomas, Gallou, Catherine, Blanc, Véronique, Rothe, Christine, Olwill, Shane

“…Background. Preclinical and clinical data suggest that 4-1BB (CD137), a costimulatory immunoreceptor mainly expressed by cytotoxic cells, represents a…”
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The HIF-1α hypoxia response in tumor-infiltrating T lymphocytes induces functional CD137 (4-1BB) for immunotherapy by Palazón, Asís, Martínez-Forero, Iván, Teijeira, Alvaro, Morales-Kastresana, Aizea, Alfaro, Carlos, Sanmamed, Miguel F, Perez-Gracia, Jose Luis, Peñuelas, Iván, Hervás-Stubbs, Sandra, Rouzaut, Ana, de Landázuri, Manuel Ortiz, Jure-Kunkel, Maria, Aragonés, Julian, Melero, Ignacio

“…The tumor microenvironment of transplanted and spontaneous mouse tumors is profoundly deprived of oxygenation as confirmed by positron emission tomographic…”
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