Search Results - "Morais, Thiago R."

H1-antihistamines as antischistosomal drugs: in vitro and in vivo studies by Xavier, Rogério P, Mengarda, Ana C, Silva, Marcos P, Roquini, Daniel B, Salvadori, Maria C, Teixeira, Fernanda S, Pinto, Pedro L, Morais, Thiago R, Ferreira, Leonardo L G, Andricopulo, Adriano D, de Moraes, Josué

“…Schistosomiasis is a socioeconomically devastating parasitic infection afflicting hundreds of millions of people and animals worldwide. It is the most…”
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Antiparasitic activity of natural and semi-synthetic tirucallane triterpenoids from Schinus terebinthifolius (Anacardiaceae): structure/activity relationships by Morais, Thiago R, da Costa-Silva, Thais A, Tempone, Andre G, Borborema, Samanta Etel T, Scotti, Marcus T, de Sousa, Raquel Maria F, Araujo, Ana Carolina C, de Oliveira, Alberto, de Morais, Sérgio Antônio L, Sartorelli, Patricia, Lago, João Henrique G

“…Leishmaniasis and Chagas are diseases caused by parasitic protozoans that affect the poorest population in the World, causing a high mortality and morbidity…”
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Can macroalgae provide promising anti-tumoral compounds? A closer look at Cystoseira tamariscifolia as a source for antioxidant and anti-hepatocarcinoma compounds by Vizetto-Duarte, Catarina, Custódio, Luísa, Acosta, Gerardo, Lago, João H G, Morais, Thiago R, Bruno de Sousa, Carolina, Gangadhar, Katkam N, Rodrigues, Maria João, Pereira, Hugo, Lima, Raquel T, Vasconcelos, M Helena, Barreira, Luísa, Rauter, Amélia P, Albericio, Fernando, Varela, João

“…Marine organisms are a prolific source of drug leads in a variety of therapeutic areas. In the last few years, biomedical, pharmaceutical and nutraceutical…”
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Anti-malarial, anti-trypanosomal, and anti-leishmanial activities of jacaranone isolated from Pentacalia desiderabilis (Vell.) Cuatrec. (Asteraceae) by Morais, Thiago R., Romoff, Paulete, Fávero, Oriana A., Reimão, Juliana Q., Lourenço, Walkyria C., Tempone, André G., Hristov, Angelica D., Di Santi, Silvia M., Lago, João Henrique G., Sartorelli, Patricia, Ferreira, Marcelo J. P.

“…Leishmaniasis, Chagas disease, and malaria affect the poorest population around the world, with an elevated mortality and morbidity. In addition, the…”
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Licarin A, a neolignan isolated from Nectandra oppositifolia Nees & Mart. (Lauraceae), exhibited moderate preclinical efficacy against Schistosoma mansoni infection by Mengarda, Ana C., Silva, Marcos P., Cirino, Maria E., Morais, Thiago R., Conserva, Geanne A. A., Lago, João Henrique G., Moraes, Josué

“…Schistosomiasis is a widespread human parasitic disease currently affecting over 200 million people, particularly in poor communities. Chemotherapy for…”
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Promethazine Exhibits Antiparasitic Properties In Vitro and Reduces Worm Burden, Egg Production, Hepatomegaly, and Splenomegaly in a Schistosomiasis Animal Model by Roquini, Daniel B, Cogo, Ramon M, Mengarda, Ana C, Mazloum, Susana F, Morais, Cristiane S, Xavier, Rogério P, Salvadori, Maria C, Teixeira, Fernanda S, Ferreira, Luiz E, Pinto, Pedro L, Morais, Thiago R, de Moraes, Josué

“…The treatment and control of schistosomiasis, a neglected disease that affects more than 200 million people worldwide, rely on the use of a single drug,…”
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Antiparasitic activity of piplartine (piperlongumine) in a mouse model of schistosomiasis by Mengarda, Ana.C., Mendonça, Poliana S., Morais, Cristiane S., Cogo, Ramon M., Mazloum, Susana F., Salvadori, Maria C., Teixeira, Fernanda S., Morais, Thiago R., Antar, Guilherme M., Lago, João Henrique G., Moraes, Josué

“…Schistosomiasis is one of the most important parasitic infections in terms of its negative effects on public health and economics. Since praziquantel is…”
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Lethal action of Licarin A derivatives in Leishmania (L.) infantum: Imbalance of calcium and bioenergetic metabolism by de Castro Levatti, Erica V., Costa-Silva, Thais A., Morais, Thiago R., Fernandes, João Paulo S., Lago, João Henrique G., Tempone, Andre G.

“…Natural metabolites present an extraordinary chemo-diversity and have been used as the inspiration for new drugs. Considering the need for new treatments…”
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Incorporation of polygodial in Langmuir films of selected lipids by Gonçalves, Giulia Elisa G., Morais, Thiago R., Lago, João Henrique G., Caseli, Luciano

“…Identification of membrane sites capable of drug binding is important to understand the interaction of bioactive compounds with biointerfaces such as microbial…”
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Improving the drug-likeness of inspiring natural products - evaluation of the antiparasitic activity against Trypanosoma cruzi through semi-synthetic and simplified analogues of licarin A by Morais, Thiago R., Conserva, Geanne A. Alves, Varela, Marina T., Costa-Silva, Thais A., Thevenard, Fernanda, Ponci, Vitor, Fortuna, Ana, Falcão, Amílcar C., Tempone, Andre G., Fernandes, João Paulo S., Lago, João Henrique G.

“…Neolignan licarin A ( 1 ) was isolated from leaves of Nectandra oppositifolia (Lauraceae) and displayed activity against trypomastigote forms of the etiologic…”
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Evaluation of Gibbilimbol B, Isolated from Piper malacophyllum (Piperaceae), as an Antischistosomal Agent by Carnaúba, Paulo U., Mengarda, Ana C., Rodrigues, Vinícius C., Morais, Thiago R., Oliveira, Alberto, Lago, João Henrique G., Moraes, Josué

“…Infections caused by parasitic worms impose a considerable worldwide health burden. One of the most impactful is schistosomiasis, a disease caused by…”
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Antitrypanosomal activity and effect in plasma membrane permeability of (−)-bornyl p-coumarate isolated from Piper cernuum (Piperaceae) by Morais, Thiago R., Costa-Silva, Thais A., Ferreira, Daiane D., Novais, Bianca J., Torrecilhas, Ana Claudia T., Tempone, Andre G., Lago, João Henrique G.

“…[Display omitted] •Compounds 1–6 were isolated from Piper cernuum (Piperaceae).•Compounds 2, 3, 5, and 6 displayed activity against T. cruzi.•Compound 6 was…”
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Antileishmanial activity of meroditerpenoids from the macroalgae Cystoseira baccata by Bruno de Sousa, Carolina, Gangadhar, Katkam N., Morais, Thiago R., Conserva, Geanne A.A., Vizetto-Duarte, Catarina, Pereira, Hugo, Laurenti, Márcia D., Campino, Lenea, Levy, Debora, Uemi, Miriam, Barreira, Luísa, Custódio, Luísa, Passero, Luiz Felipe D., Lago, João Henrique G., Varela, João

“…The development of novel drugs for the treatment of leishmaniases continues to be crucial to overcome the severe impacts of these diseases on human and animal…”
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Simplified Derivatives of Dibenzylbutyrolactone Lignans from Hydrocotyle bonariensis as Antitrypanosomal Candidates by Souza, Dalete Christine S., Costa‐Silva, Thais A., Morais, Thiago R., Brito, Juliana R., Ferreira, Edgard A., Antar, Guilherme M., Sartorelli, Patricia, Tempone, Andre G., Lago, João Henrique G.

“…The search for the pharmacophore of a bioactive compound, crucial for drug discovery studies, involves the adequate arrangement of different atoms in the…”
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Cystoseira algae (Fucaceae): update on their chemical entities and biological activities by Bruno de Sousa, Carolina, Gangadhar, Katkam N., Macridachis, Jorge, Pavão, Madalena, Morais, Thiago R., Campino, Lenea, Varela, João, Lago, João Henrique G.

“…[Display omitted] Cystoseira (Sargassaceae) is a genus of marine brown algae composed of about 40 species, which is distributed along the Eastern Atlantic and…”
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Application of an Ionic Liquid in the Microwave Assisted Extraction of Cytotoxic Metabolites from Fruits of Schinus terebinthifolius Raddi (Anacardiaceae) by Morais, Thiago, Coutinho, Ana Paula, Camilo, Fernanda, Martins, Tereza, Sartorelli, Patricia, Massaoka, Mariana, Figueiredo, Carlos, Lago, João Henrique

“…This work reports the application of an ionic liquid (1-butyl-3-methylimidazolium bromide, BMImBr) in the microwave assisted extraction (MAE) of metabolites…”
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Promethazine exhibits antiparasitic properties in vitro and reduces worm burden, egg production, hepato-, and splenomegaly in a schistosomiasis animal model by Roquini, Daniel B, Cogo, Ramon M, Mengarda, Ana C, Mazloum, Susana F, Morais, Cristiane S, Xavier, Rogério P, Salvadori, Maria C, Teixeira, Fernanda S, Ferreira, Luiz E, Pinto, Pedro L, Morais, Thiago R, de Moraes, Josué

“…The treatment and control of schistosomiasis, a neglected disease that affects more than 200 million people worldwide, rely on the use of a single drug,…”
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Anti-malarial, anti-trypanosomal, and anti-leishmanial activities of jacaranone isolated from Pentacalia desiderabilis by Morais, Thiago R, Romoff, Paulete, Favero, Oriana A, Reimao, Juliana Q, Lourenco, Walkyria C, Tempone, Andre G, Hristov, Angelica D, Santi, Silvia M. Di, Lago, Joao Henrique G, Sartorelli, Patricia, Ferreira, Marcelo J.P

“…Leishmaniasis, Chagas disease, and malaria affect the poorest population around the world, with an elevated mortality and morbidity. In addition, the…”
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