Search Results - "Morais, Katia L P"

Amblyomin-X induces ER stress, mitochondrial dysfunction, and caspase activation in human melanoma and pancreatic tumor cell by Morais, Katia L. P., Pacheco, Mario Thiego Fernandes, Berra, Carolina Maria, Bosch, Rosemary V., Sciani, Juliana Mozer, Chammas, Roger, de Freitas Saito, Renata, Iqbal, Asif, Chudzinski-Tavassi, Ana Marisa

“…During the last two decades, new insights into proteasome function and its role in several human diseases made it a potential therapeutic target. In this…”
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A novel proteasome inhibitor acting in mitochondrial dysfunction, ER stress and ROS production by Maria, Durvanei Augusto, de Souza, Jean Gabriel, Morais, Katia L. P., Berra, Carolina Maria, Zampolli, Hamilton de Campos, Demasi, Marilene, Simons, Simone Michaela, de Freitas Saito, Renata, Chammas, Roger, Chudzinski-Tavassi, Ana Marisa

“…Summary In cancer-treatment, potentially therapeutic drugs trigger their effects through apoptotic mechanisms. Generally, cell response is manifested by Bcl-2…”
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Bothrops jararaca peptide with anti-hypertensive action normalizes endothelium dysfunction involved in physiopathology of preeclampsia by Benedetti, Gabriel, Morais, Katia L P, Guerreiro, Juliano R, de Oliveira, Eduardo Fontana, Hoshida, Mara Sandra, Oliveira, Leandro, Sass, Nelson, Lebrun, Ivo, Ulrich, Henning, Lameu, Claudiana, de Camargo, Antonio Carlos Martins

“…Preeclampsia, a pregnancy-specific syndrome characterized by hypertension, proteinuria and edema, is a major cause of fetal and maternal morbidity and…”
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central nervous system as target for antihypertensive actions of a proline-rich peptide from Bothrops jararaca venom by Lameu, Claudiana, Hayashi, Mirian A.F, Guerreiro, Juliano R, Oliveira, Eduardo F, Lebrun, Ivo, Pontieri, Vera, Morais, Kátia L.P, Camargo, Antonio C.M, Ulrich, Henning

“…Pyroglutamyl proline-rich oligopeptides, present in the venom of the pit viper Bothrops jararaca (Bj-PROs), are the first described naturally occurring…”
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Distinct systemic immune networks define severe vs . mild COVID-19 in hematologic and solid cancer patients by Pignataro-Oshiro, Flávio, Figueiredo, Amanda B, Galdino, Nayane A L, Morais, Katia L P, Dutra, Walderez O, Silva, Bianca Grassi de Miranda, Feriani, Diego, Abrantes, Flávia de Azevedo, Silva, Ivan Leonardo Avelino França E, Filho, Jayr Schmidt, Framil, Juliana Valéria de Souza, Cesca, Marcelle Goldner, Riechelmann, Rachel Simões Pimenta, Batista, Marjorie V, Gollob, Kenneth J

“…The COVID-19 pandemic, caused by the coronavirus SARS-CoV-2, has impacted health across all sectors of society. A cytokine-release syndrome, combined with an…”
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Dynein function and protein clearance changes in tumor cells induced by a Kunitz-type molecule, Amblyomin-X by Pacheco, Mario T F, Berra, Carolina M, Morais, Kátia L P, Sciani, Juliana M, Branco, Vania G, Bosch, Rosemary V, Chudzinski-Tavassi, Ana M

“…Amblyomin-X is a Kunitz-type recombinant protein identified from the transcriptome of the salivary glands of the tick Amblyomma cajennense and has…”
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A Genome-wide Association Study Identifies SERPINB10, CRLF3, STX7, LAMP3, IFNG-AS1, and KRT80 As Risk Loci Contributing to Cutaneous Leishmaniasis in Brazil by Castellucci, Léa C, Almeida, Lucas, Cherlin, Svetlana, Fakiola, Michaela, Francis, Richard W, Carvalho, Edgar M, Santos da Hora, Anadílton, do Lago, Tainã Souza, Figueiredo, Amanda B, Cavalcanti, Clara M, Alves, Natalia S, Morais, Katia L P, Teixeira-Carvalho, Andréa, Dutra, Walderez O, Gollob, Kenneth J, Cordell, Heather J, Blackwell, Jenefer M

“…Our goal was to identify genetic risk factors for cutaneous leishmaniasis (CL) caused by Leishmania braziliensis. Genotyping 2066 CL cases and 2046 controls…”
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Systemic immune mediators reflect tumour‐infiltrating lymphocyte intensity and predict therapeutic response in triple‐negative breast cancer by Lopes, Ananda D., Galdino, Nayane A. L., Figueiredo, Amanda B., Brianese, Rafael C., Morais, Katia L. P., De Brot, Marina, Osório, Cynthia A. B. T., Teixeira‐Carvalho, Andrea, Calsavara, Vinicius F., Evangelista, Guilherme F. B., Alves, Natalia S., Makdissi, Fabiana B., Sanches, Solange M., Cordeiro de Lima, Vladmir C., Carraro, Dirce M., Gollob, Kenneth J.

“…Triple‐negative breast cancer (TNBC) is an aggressive form of breast cancer (BC). Neoadjuvant chemotherapy has proven efficacy in its treatment, and a…”
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Interactions between the NO-Citrulline Cycle and Brain-derived Neurotrophic Factor in Differentiation of Neural Stem Cells by Lameu, Claudiana, Trujillo, Cleber A., Schwindt, Telma T., Negraes, Priscilla D., Pillat, Micheli M., Morais, Katia L.P., Lebrun, Ivo, Ulrich, Henning

“…The diffusible messenger NO plays multiple roles in neuroprotection, neurodegeneration, and brain plasticity. Argininosuccinate synthase (AS) is a ubiquitous…”
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Amblyomin-X, a recombinant Kunitz-type inhibitor, regulates cell adhesion and migration of human tumor cells by Schmidt, Mariana Costa Braga, Morais, Katia L.P., Almeida, Maíra Estanislau Soares de, Iqbal, Asif, Goldfeder, Mauricio Barbugiani, Chudzinski-Tavassi, Ana Marisa

“…In a tumor microenvironment, endothelial cell migration and angiogenesis allow cancer to spread to other organs causing metastasis.  Indeed, a number of…”
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Tick salivary gland as potential natural source for the discovery of promising antitumor drug candidates by Chudzinski-Tavassi, Ana Marisa, Morais, Katia L.P, Pacheco, Mário Thiego Fernandes, Pasqualoto, Kerly Fernanda Mesquita, de Souza, Jean Gabriel

“…Abstract Nowadays, the relationship between cancer blood coagulation is well established. Regarding biodiversity and bioprospection, the tick biology has…”
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Specific role of cytoplasmic dynein in the mechanism of action of an antitumor molecule, Amblyomin-X by Pacheco, Mario T.F., Morais, Kátia L.P., Berra, Carolina M., Demasi, Marilene, Sciani, Juliana M., Branco, Vania G., Bosch, Rosemary V., Iqbal, Asif, Chudzinski-Tavassi, Ana Marisa

“…The Kunitz-type recombinant protein, Amblyomin-X, is an antitumor recombinant molecule from a cDNA library prepared from the salivary glands of the tick…”
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Proline rich-oligopeptides: Diverse mechanisms for antihypertensive action by Morais, Katia L.P., Ianzer, Danielle, Miranda, José Rodolfo R., Melo, Robson L., Guerreiro, Juliano R., Santos, Robson A.S., Ulrich, Henning, Lameu, Claudiana

“…•Antihypertensive activity of Bj-proline-rich oligopeptides.•Diversity of mechanisms for antihypertensive action of Bj-proline-rich…”
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A Lipocalin-Derived Peptide Modulating Fibroblasts and Extracellular Matrix Proteins by Carrijo-Carvalho, Linda Christian, Maria, Durvanei Augusto, Ventura, Janaina S., Morais, Kátia L. P., Melo, Robson Lopes, Rodrigues, Consuelo Junqueira, Chudzinski-Tavassi, Ana Marisa

“…Lipocalin family members have been implicated in development, regeneration, and pathological processes, but their roles are unclear. Interestingly, these…”
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A Kunitz-type FXa inhibitor affects tumor progression, hypercoagulable state and triggers apoptosis by Ventura, Janaína Souza, Faria, Fernanda, Batista, Isabel Fátima Correia, Simons, Simone Michaela, Oliveira, Daniella Gorete Lourenço, Morais, Katia L.P, Chudzinski-Tavassi, Ana Marisa

“…Abstract Cancer is linked to hypercoagulability, and many studies have shown that anticoagulant drugs affect tumor progression. In this study was demonstrated…”
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Promising pharmacological profile of a Kunitz-type inhibitor in murine renal cell carcinoma model by de Souza, Jean Gabriel, Morais, Katia L.P., Anglés-Cano, Eduardo, Boufleur, Pamela, de Mello, Evandro Sobroza, Maria, Durvanei Augusto, Origassa, Clarice Silvia Taemi, de Campos Zampolli, Hamilton, Câmara, Niels Olsen Saraiva, Berra, Carolina Maria, Bosch, Rosemary Viola, Chudzinski-Tavassi, Ana Marisa

“…Renal cell carcinoma (RCC), also called kidney cancer or renal adenocarcinoma, is highly resistant to current treatments. It has been previously reported that…”
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Rational development of a novel TFPI-like inhibitor from Amblyomma cajennense tick by Morais, Katia L. P., Pasqualoto, Kerly Fernanda Mesquita, Pacheco, Mario Thiego Fernandes, Berra, Carolina Maria, Alvarez-Flores, Miryam Paola, Chudzinski-Tavassi, Ana Marisa

“…Abstract Hematophagous organisms have been described to possess specific blood coagulation inhibitors with different structures and novel mechanism of action…”
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